Search Results - "Manfredi, Francesco"

Lean adoption in hospitals: the role of contextual factors and introduction strategy by Rosa, Angelo, Marolla, Giuliano, Lega, Federico, Manfredi, Francesco

“…Abstract Background In the scientific literature, many studies describe the application of lean methodology in the hospital setting. Most of the articles focus…”
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CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome by Arcangeli, Silvia, Bove, Camilla, Mezzanotte, Claudia, Camisa, Barbara, Falcone, Laura, Manfredi, Francesco, Bezzecchi, Eugenia, El Khoury, Rita, Norata, Rossana, Sanvito, Francesca, Ponzoni, Maurilio, Greco, Beatrice, Moresco, Marta Angiola, Carrabba, Matteo G, Ciceri, Fabio, Bonini, Chiara, Bondanza, Attilio, Casucci, Monica

“…Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to achieve complete responses and prevent relapses. These features are…”
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TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals by Manfredi, Francesco, Cianciotti, Beatrice Claudia, Potenza, Alessia, Tassi, Elena, Noviello, Maddalena, Biondi, Andrea, Ciceri, Fabio, Bonini, Chiara, Ruggiero, Eliana

“…Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to harness T cell specificity and function to fight diseases. Based on the…”
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Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting by Fiani, Maria Luisa, Barreca, Valeria, Sargiacomo, Massimo, Ferrantelli, Flavia, Manfredi, Francesco, Federico, Maurizio

“…Immunosuppression at tumor microenvironment (TME) is one of the major obstacles to be overcome for an effective therapeutic intervention against solid tumors…”
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Correlations Between Mandibular Kinematics and Electromyography During the Masticatory Cycle: An Observational Study by Digital Analysis by Nota, Alessandro, Pittari, Laura, Monticciolo, Francesco Manfredi, Lannes, Alessia Claudia, Tecco, Simona

“…The analysis of the masticatory cycle plays a fundamental role in studying the functions of the stomatognathic system and evaluating temporomandibular…”
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The Management of Toe Walking in Children with Autism Spectrum Disorder: "Cast and Go" by Manfredi, Francesco, Riefoli, Flavia, Coviello, Michele, Dibello, Daniela

“…Background: Toe walking is associated with autism spectrum disorders (ASD). Correction of this “behavior” is a health challenge. The toe walker is affected by…”
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Strong SARS-CoV-2 N-Specific CD8 + T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice by Ferrantelli, Flavia, Chiozzini, Chiara, Manfredi, Francesco, Leone, Patrizia, Spada, Massimo, Di Virgilio, Antonio, Giovannelli, Andrea, Sanchez, Massimo, Cara, Andrea, Michelini, Zuleika, Federico, Maurizio

“…SARS-CoV-2-specific CD8 T cell immunity is expected to counteract viral variants in both efficient and durable ways. We recently described a way to induce a…”
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Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation by Tassi, Elena, Noviello, Maddalena, De Simone, Pantaleo, Lupo-Stanghellini, Maria T, Doglio, Matteo, Serio, Francesca, Abbati, Danilo, Beretta, Valeria, Valtolina, Veronica, Oliveira, Giacomo, Racca, Sara, Campodonico, Edoardo, Ruggiero, Eliana, Clerici, Daniela, Giglio, Fabio, Lorentino, Francesca, Dvir, Roee, Xue, Elisabetta, Farina, Francesca, Oltolini, Chiara, Manfredi, Francesco, Vago, Luca, Corti, Consuelo, Bernardi, Massimo, Clementi, Massimo, Brix, Liselotte, Ciceri, Fabio, Peccatori, Jacopo, Greco, Raffaella, Bonini, Chiara

“…After allogeneic hematopoietic stem cell transplantation (HSCT), the emergence of circulating cytomegalovirus (CMV)- specific T cells correlates with…”
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Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases by Ferrantelli, Flavia, Chiozzini, Chiara, Leone, Patrizia, Manfredi, Francesco, Federico, Maurizio

“…Neurodegenerative diseases are commonly generated by intracellular accumulation of misfolded/aggregated mutated proteins. These abnormal protein aggregates…”
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Simultaneous CD8 + T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs by Ferrantelli, Flavia, Chiozzini, Chiara, Manfredi, Francesco, Giovannelli, Andrea, Leone, Patrizia, Federico, Maurizio

“…Most advanced vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 are designed to induce antibodies against spike (S) protein…”
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The Contribution of Extracellular Nef to HIV-Induced Pathogenesis by Olivetta, Eleonora, Arenaccio, Claudia, Manfredi, Francesco, Anticoli, Simona, Federico, Maurizio

“…Nef is an accessory protein expressed exclusively in primate lentiviruses. It is devoid of enzymatic activities while interacting with several cell proteins as…”
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TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells by Cianciotti, Beatrice Claudia, Magnani, Zulma Irene, Ugolini, Alessia, Camisa, Barbara, Merelli, Ivan, Vavassori, Valentina, Potenza, Alessia, Imparato, Antonio, Manfredi, Francesco, Abbati, Danilo, Perani, Laura, Spinelli, Antonello, Shifrut, Eric, Ciceri, Fabio, Vago, Luca, Di Micco, Raffaella, Naldini, Luigi, Genovese, Pietro, Ruggiero, Eliana, Bonini, Chiara

“…In adoptive T cell therapy, the long term therapeutic benefits in patients treated with engineered tumor specific T cells are limited by the lack of long term…”
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Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells by Tassi, Elena, Bergamini, Alice, Wignall, Jessica, Sant’Angelo, Miriam, Brunetto, Emanuela, Balestrieri, Chiara, Redegalli, Miriam, Potenza, Alessia, Abbati, Danilo, Manfredi, Francesco, Cangi, Maria Giulia, Magliacane, Gilda, Scalisi, Fabiola, Ruggiero, Eliana, Maffia, Maria Chiara, Trippitelli, Federica, Rabaiotti, Emanuela, Cioffi, Raffaella, Bocciolone, Luca, Candotti, Giorgio, Candiani, Massimo, Taccagni, Gianluca, Schultes, Birgit, Doglioni, Claudio, Mangili, Giorgia, Bonini, Chiara

“…Introduction Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains…”
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Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein by Manfredi, Francesco, Chiozzini, Chiara, Ferrantelli, Flavia, Leone, Patrizia, Giovannelli, Andrea, Sanchez, Massimo, Federico, Maurizio

“…We propose an innovative anti-SARS-CoV-2 immune strategy based on extracellular vesicles (EVs) inducing an anti-SARS-CoV-2 N CD8+ T cytotoxic lymphocyte (CTL)…”
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The longitudinal characterization of immune responses in COVID-19 patients reveals novel prognostic signatures for disease severity, patients' survival and long COVID by Noviello, Maddalena, De Lorenzo, Rebecca, Chimienti, Raniero, Maugeri, Norma, De Lalla, Claudia, Siracusano, Gabriel, Lorè, Nicola Ivan, Rancoita, Paola Maria Vittoria, Cugnata, Federica, Tassi, Elena, Dispinseri, Stefania, Abbati, Danilo, Beretta, Valeria, Ruggiero, Eliana, Manfredi, Francesco, Merolla, Aurora, Cantarelli, Elisa, Tresoldi, Cristina, Pastori, Claudia, Caccia, Roberta, Sironi, Francesca, Marzinotto, Ilaria, Saliu, Fabio, Ghezzi, Silvia, Lampasona, Vito, Vicenzi, Elisa, Cinque, Paola, Manfredi, Angelo Andrea, Scarlatti, Gabriella, Dellabona, Paolo, Lopalco, Lucia, Di Serio, Clelia, Malnati, Mauro, Ciceri, Fabio, Rovere-Querini, Patrizia, Bonini, Chiara

“…SARS-CoV-2 pandemic still poses a significant burden on global health and economy, especially for symptoms persisting beyond the acute disease. COVID-19…”
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Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells by Magnani, Chiara F., Myburgh, Renier, Brunn, Silvan, Chambovey, Morgane, Ponzo, Marianna, Volta, Laura, Manfredi, Francesco, Pellegrino, Christian, Pascolo, Steve, Miskey, Csaba, Sandoval-Villegas, Nicolás, Ivics, Zoltán, Shizuru, Judith A., Neri, Dario, Manz, Markus G.

“…Discrimination between hematopoietic stem cells and leukemic stem cells remains a major challenge for acute myeloid leukemia immunotherapy. CAR T cells…”
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Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles by Manfredi, Francesco, Chiozzini, Chiara, Ferrantelli, Flavia, Leone, Patrizia, Pugliese, Katherina, Spada, Massimo, Di Virgilio, Antonio, Giovannelli, Andrea, Valeri, Mauro, Cara, Andrea, Michelini, Zuleika, Andreotti, Mauro, Federico, Maurizio

“…Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory…”
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SARS-CoV-2-Specific CD8+ T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection by Ferrantelli, Flavia, Manfredi, Francesco, Chiozzini, Chiara, Leone, Patrizia, Pugliese, Katherina, Spada, Massimo, Di Virgilio, Antonio, Giovannelli, Andrea, Valeri, Mauro, Cara, Andrea, Michelini, Zuleika, Andreotti, Mauro, Federico, Maurizio

“…Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the…”
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The C-Terminal Domain of Nefmut Is Dispensable for the CD8+ T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles by Chiozzini, Chiara, Manfredi, Francesco, Ferrantelli, Flavia, Leone, Patrizia, Giovannelli, Andrea, Olivetta, Eleonora, Federico, Maurizio

“…Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nefmut fused at its C-terminus to viral and tumor antigens…”
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HPV-E7 delivered by engineered exosomes elicits a protective CD8⁺ T cell-mediated immune response by Di Bonito, Paola, Ridolfi, Barbara, Columba-Cabezas, Sandra, Giovannelli, Andrea, Chiozzini, Chiara, Manfredi, Francesco, Anticoli, Simona, Arenaccio, Claudia, Federico, Maurizio

“…We developed an innovative strategy to induce a cytotoxic T cell (CTL) immune response against protein antigens of choice. It relies on the production of…”
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