Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients

Highlights • A significant correlation between 8-iso-PGF2α and eGFR in T2DM patients. • Increasing level of MDA was mildly correlated with the decline in eGFR (MDRD). • Increasing UACR inversely correlate with eGFR (corrected-CG, MDRD, and CKD-EPI). • Increased 8-iso-PGF2α and MDA in T2DM patients m...

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Published in:	Diabetes research and clinical practice Vol. 108; no. 1; pp. 193 - 200
Main Authors:	Sauriasari, R, Andrajati, R, Azizahwati, Dharmeizar, Saputri, D.A, Muris, R.U, Manfaatun, A, Amanda, O.F, Setiawan, H, Sakano, N, Wang, D.H, Ogino, K
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-04-2015
Subjects:	8-iso-PGF2α Adult Aged Biomarkers - blood Biomarkers - urine Creatinine - metabolism Diabetes Mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - metabolism Diabetic Nephropathies - epidemiology Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Dinoprost - analogs & derivatives Dinoprost - blood Endocrinology & Metabolism Enzyme-Linked Immunosorbent Assay Estimated Glomerular Filtration Rate Female Glomerular Filtration Rate Humans Indonesia - epidemiology Lipid Peroxidation Male Malondialdehyde - metabolism Middle Aged Prevalence Spectrophotometry Urine Albumin to Creatinine Ratio Indonesia 8-iso-PGF 2α Estimated Glomerular Filtration Rate Diabetes Mellitus Urine Albumin to Creatinine Ratio 8-iso-PGF2α 8-iso-PGF(2α)
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Summary:	Highlights • A significant correlation between 8-iso-PGF2α and eGFR in T2DM patients. • Increasing level of MDA was mildly correlated with the decline in eGFR (MDRD). • Increasing UACR inversely correlate with eGFR (corrected-CG, MDRD, and CKD-EPI). • Increased 8-iso-PGF2α and MDA in T2DM patients may play a role in the pathophysiologic significance of diabetic nephropathy, in which 8-iso-PGF2α contributes in the initiating process.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2014.12.016