Search Results - "Manevich, Y"

Activation of the Antioxidant Enzyme 1-CYS Peroxiredoxin Requires Glutathionylation Mediated by Heterodimerization with πGST by Manevich, Y, Feinstein, S I, Fisher, A B

“…1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, can protect cells against membrane oxidation through glutathione (GSH)-dependent…”
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Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation by Manevich, Y., Hutchens, S., Tew, K.D., Townsend, D.M.

“…The dual-functioning antioxidant enzyme peroxiredoxin VI (Prdx6) detoxifies lipid peroxides particularly in biological membranes, and its peroxidase function…”
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Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer by Turner-Ivey, B, Manevich, Y, Schulte, J, Kistner-Griffin, E, Jezierska-Drutel, A, Liu, Y, Neumann, C A

“…Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H 2 O 2 -scavenging function, mediates cell signaling through redox-specific…”
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Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation by Bartolini, D., Piroddi, M., Tidei, C., Giovagnoli, S., Pietrella, D., Manevich, Y., Tew, K.D., Giustarini, D., Rossi, R., Townsend, D.M., Santi, C., Galli, F.

“…Catalytic properties and cellular effects of the glutathione peroxidase (GPx)-mimetic compound PhSeZnCl or its d,l-lactide polymer microencapsulation form…”
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Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome by Manevich, Y., Hutchens, S., Halushka, P.V., Tew, K.D., Townsend, D.M., Jauch, E.C., Borg, K.

“…Traumatic brain injury (TBI) patients would benefit from the identification of reliable biomarkers to predict outcomes and treatment strategies. In our study,…”
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Overexpression of antioxidant enzyme Prdx6 in mice protects lung cells from injury by hydrogen peroxide by Wang, Y, Manevich, Y, Feinstein, S.I, Bates, S.R, Beers, M.F, Phelan, S.A, Fisher, A.B

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Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic by Uys, J.D, Manevich, Y, DeVane, L.C, He, L, Garret, T.E, Pazoles, C.J, Tew, K.D, Townsend, D.M

“…Abstract NOV-002 is a glutathione disulfide (GSSG) mimetic that is the subject of clinical investigation in oncology indications. GSSG is reduced by…”
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Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism by Manevich, Yefim, Fisher, Aron B.

“…Peroxiredoxin 6 (Prdx6), a bifunctional 25-kDa protein with both GSH peroxidase and phospholipase A 2 activities, is the only mammalian 1-Cys member of the…”
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Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344 by Manevich, Yefim, Reyes, Leticia, Britten, Carolyn D, Townsend, Danyelle M, Tew, Kenneth D

“…ME-344 [(3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol] is a second-generation derivative natural product isoflavone presently under…”
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Direct Evidence for the Formation of a Complex between 1-Cysteine Peroxiredoxin and Glutathione S-Transferase π with Activity Changes in Both Enzymes by Ralat, Luis A, Manevich, Yefim, Fisher, Aron B, Colman, Roberta F

“…Glutathione S-tranferase π (GST π) has been shown to reactivate oxidized 1-cysteine peroxiredoxin (1-Cys Prx, Prx VI, Prdx6, and AOP2). We now demonstrate that…”
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The importance of choice of anaesthetics in studying radiation effects in the 9L rat glioma by Pavlovic, M, Wróblewski, K, Manevich, Y, Kim, S, Biaglow, J E

“…In the present study we demonstrate that the glycolysis of the tumour 9L glioma, in vivo, may be manipulated with ketamine/xylazine combinations of…”
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Allelic Variants of GSTP Specifically Regulate a Prdx6-mediated Protection of Membrane Against Lipid Peroxidation by Manevich⁎, Y., Hutchens, S., Townsend, D., Tew, K.D.

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Peroxiredoxin VI Oxidation in Cerebrospinal Fluid Correlates with TBI Outcome by Manevich, Y., Hutchens, S., Halushka, P.V., Tew, K.D., Townsend, D. M., Jauch, E.C., Borg, K.

“…Traumatic brain injury (TBI) patients would benefit from the identification of reliable biomarkers to predict outcomes and treatment strategies. In our study,…”
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Benzoyl Peroxide Acts as a Promoter of Radiation-Induced Malignant Transformation in Vitro by Kennedy, S.H., Manevich, Y., Biaglow, J.

“…The experiments reported here demonstrate that benzoyl peroxide (BP) can promote radiation induced transformation in vitro . BP is shown to be capable of…”
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Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress by Wang, Yan, Feinstein, Sheldon I, Manevich, Yefim, Ho, Ye-Shih, Fisher, Aron B

“…Mice with knock-out of peroxiredoxin 6 (Prdx6), a recently described antioxidant enzyme, were evaluated for susceptibility to lung injury with paraquat (PQ)…”
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Lung injury and mortality with hyperoxia are increased in Peroxiredoxin 6 gene-targeted mice by Wang, Yan, Feinstein, Sheldon I., Manevich, Yefim, Ho, Ye-Shih, Fisher, Aron B.

“…Overexpression of peroxiredoxin 6 (Prdx6) has been shown to protect lungs of mice against hyperoxia-mediated injury. In this study, we evaluated whether…”
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1-Cys Peroxiredoxin Overexpression Protects Cells against Phospholipid Peroxidation-Mediated Membrane Damage by Manevich, Yefim, Sweitzer, Tom, Pak, Jhang Ho, Feinstein, Sheldon I., Muzykantov, Vladimir, Fisher, Aron B.

“…1-Cys peroxiredoxin (1-cysPrx) is a novel antioxidant enzyme able to reduce phospholipid hydroperoxides in vitro by using glutathione as a reductant. This…”
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Lipid-specific fluorescent probes in studies of biological membranes by Bergelson, L D, Molotkovsky, J G, Manevich, Y M

“…Lipid-specific fluorescent probes are natural lipids carrying an apolar fluorophore in one of the hydrocarbon chains. Since such probes retain the head groups…”
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Transgenic Mice Overexpressing Peroxiredoxin 6 Show Increased Resistance to Lung Injury in Hyperoxia by Wang, Yan, Phelan, Shelley A, Manevich, Yefim, Feinstein, Sheldon I, Fisher, Aron B

“…Peroxiredoxin 6 (Prd x 6) is a novel peroxidase enzyme that is expressed at a high level in the lung. We tested the hypothesis that transgenic (Tg) mice…”
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Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects against hyperoxic injury by Wang, Yan, Manevich, Yefim, Feinstein, Sheldon I, Fisher, Aron B

“…1-Cys peroxiredoxin (1-cysPrx) is a novel antioxidant enzyme that has been shown to reduce a broad spectrum of peroxides including phospholipid hydroperoxides…”
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