Search Results - "Maness, L M"

Peptides crossing the blood–brain barrier: some unusual observations by Kastin, Abba J., Pan, Weihong, Maness, Lawrence M., Banks, William A.

“…An interactive blood–brain barrier (BBB) helps regulate the passage of peptides from the periphery to the CNS and from the CNS to the periphery. Many peptides…”
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The neurotrophins and their receptors: structure, function, and neuropathology by Maness, L M, Kastin, A J, Weber, J T, Banks, W A, Beckman, B S, Zadina, J E

“…The neurotrophins are a family of polypeptides that promote differentiation and survival of select peripheral and central neurons. Nerve growth factor,…”
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Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice by Maness, Lawrence M, Banks, William A, Kastin, Abba J

“…In lean CD-1 mice, leptin is delivered into the brain by a saturable transport mechanism. Previous work has shown that obesity is associated with decreased…”
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Saturable entry of ciliary neurotrophic factor into brain by Pan, Weihong, Kastin, Abba J, Maness, Lawrence M, Brennan, J.Matthew

“…Ciliary neurotrophic factor (CNTF), like tumor necrosis factor- α (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), is a cytokine with…”
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Selective transport of blood-borne interleukin-1α into the posterior division of the septum of the mouse brain by Maness, Lawrence M., Banks, William A., Zadina, James E., Kastin, Abba J.

“…Film autoradiography was used to demonstrate the transport and sites of accumulation of blood-borne radioiodinated interleukin-1α (Il-1α) and other cytokines…”
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Leptin enters the brain by a saturable system independent of insulin by Banks, William A., Kastin, Abba J., Huang, Weitao, Jaspan, Jonathan B., Maness, Lawrence M.

“…Leptin, or OB protein, is produced by fat cells and may regulate body weight by acting on the brain. To reach the brain, circulating leptin must cross the…”
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Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor by Kastin, Abba J, Pan, Weihong, Maness, Lawrence M, Koletsky, Richard J, Ernsberger, Paul

“…Leptin is produced in adipose tissue in the periphery, but its satiety effect is exerted in the CNS that it reaches by a saturable transport system across the…”
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Fate of leptin after intracerebroventricular injection into the mouse brain by Maness, L M, Kastin, A J, Farrell, C L, Banks, W A

“…The fate of the metabolic regulatory protein leptin was studied after intracerebroventricular (i.c.v.) administration into the lateral ventricle of the brain…”
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Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier by Banks, W A, Kastin, A J, Sam, H M, Cao, V T, King, B, Maness, L M, Schally, A V

“…Peptides have been shown to be transported in the direction of both blood to brain and brain to blood. Although blood to brain transport is known to occur at…”
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In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier by Maresh, Grace A., Maness, Lawrence M., Zadina, James E., Kastin, Abba J.

“…A saturable blood-to-brain transport system for leptin across the blood-brain barrier (BBB) has been observed in vivo. Since the main component of the…”
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Permeability of the blood-brain barrier to amylin by Banks, W A, Kastin, A J, Maness, L M, Huang, W, Jaspan, J B

“…Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent diabetes mellitus, and its deposition may contribute to the central…”
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Lack of saturable transport across the blood-brain barrier in either direction for beta-amyloid1-28 (Alzheimer's disease protein) by Banks, W A, Kastin, A J, Barrera, C M, Maness, L M

“…beta-Amyloid and related peptides are components of the neurofibrillary tangles found in the brains of patients with Alzheimer's disease and have been…”
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Chronic loss of ovarian function decreases transport of leptin into mouse brain by Kastin, Abba J, Akerstrom, Victoria, Maness, Lawrence M

“…Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression…”
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Differential transport of rat and human interleukin-1α across the blood–brain barrier and blood–testis barrier in rats by Plotkin, Scott R., Banks, William A., Maness, Lawrence M., Kastin, Abba J.

“…Human interleukin-1α is transported across the murine blood–brain barrier (BBB) and blood–testis barrier (BTB) by a saturable transport system. Differences in…”
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Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier by Maness, L M, Banks, W A, Podlisny, M B, Selkoe, D J, Kastin, A J

“…Previous studies have suggested that the amyloid beta-protein present in the brains of patients with Alzheimer's disease may be derived in part from peripheral…”
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Periventricular penetration and disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin by Maness, Lawrence M., Banks, William A., Zadina, James E., Kastin, Abba J.

“…The penetration of four radioiodinated materials—Tyr-MIF-1, DAMGO, tyrosine, and albumin—into the periventricular tissue after ICV injection was studied in…”
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Interactions of β-Amyloids with the Blood-Brain Barrier by BANKS, WILLIAM A., KASTIN, ABBA J., MANESS, LAWRENCE M., BANKS, MARIAN F., SHAYO, MARCOS, McLAY, ROBERT N.

“…Blood‐borne β‐amyloids (Aβs) could affect brain function by (1) crossing the BBB to directly interact with brain tissues or (2) altering BBB function by…”
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Differential transport of rat and human interleukin-1alpha across the blood-brain barrier and blood-testis barrier in rats by Plotkin, S R, Banks, W A, Maness, L M, Kastin, A J

“…Human interleukin-1alpha is transported across the murine blood-brain barrier (BBB) and blood-testis barrier (BTB) by a saturable transport system. Differences…”
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Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1alpha to the brain by Maness, L M, Kastin, A J, Banks, W A

“…Diffusion from brain regions lacking a blood-brain barrier (BBB) and saturable transport across capillaries are possible pathways for the entry of blood-borne…”
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Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide by Pan, Weihong, Solomon, Beka, Maness, Lawrence M, Kastin, Abba J

“…Amyloid-beta peptides (Abeta) play an important role in the pathophysiology of dementia of the Alzheimer's type and in amyloid angiopathy. Abeta outside the…”
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