Search Results - "Manes, Santos"

Orchestration of lymphocyte chemotaxis by mitochondrial dynamics by Campello, Silvia, Lacalle, Rosa Ana, Bettella, Monica, Mañes, Santos, Scorrano, Luca, Viola, Antonella

“…Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must…”
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Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals by Arranz-Nicolás, Javier, Ogando, Jesús, Soutar, Denise, Arcos-Pérez, Raquel, Meraviglia-Crivelli, Daniel, Mañes, Santos, Mérida, Isabel, Ávila-Flores, Antonia

“…The arsenal of cancer therapies has evolved to target T lymphocytes and restore their capacity to destroy tumor cells. T cells rely on diacylglycerol (DAG) to…”
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CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway by TARDAGUILA, Manuel, MIRA, Emilia, GARCIA-CABEZAS, Miguel A, FEIJOO, Anna M, QUINTELA-FANDINO, Miguel, AZCOITIA, Iñigo, LIRA, Sergio A, MANES, Santos

“…Chemokines are relevant molecules in shaping the tumor microenvironment, although their contributions to tumorigenesis are not fully understood. We studied the…”
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p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β by Rackov, Gorjana, Hernández-Jiménez, Enrique, Shokri, Rahman, Carmona-Rodríguez, Lorena, Mañes, Santos, Álvarez-Mon, Melchor, López-Collazo, Eduardo, Martínez-A, Carlos, Balomenos, Dimitrios

“…M1 and M2 macrophage phenotypes, which mediate proinflammatory and antiinflammatory functions, respectively, represent the extremes of immunoregulatory…”
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Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial by Quintela-Fandino, Miguel, Holgado, Esther, Manso, Luis, Morales, Serafin, Bermejo, Begoña, Colomer, Ramon, Apala, Juan V, Blanco, Raquel, Muñoz, Manuel, Caleiras, Eduardo, Iranzo, Vega, Martinez, Mario, Dominguez, Orlando, Hornedo, Javier, Gonzalez-Cortijo, Lucia, Cortes, Javier, Gasol Cudos, Ariadna, Malon, Diego, Lopez-Alonso, Antonio, Moreno-Ortíz, María C, Mouron, Silvana, Mañes, Santos

“…Preclinical research suggests that the efficacy of immune checkpoint inhibitors in breast cancer can be enhanced by combining them with antiangiogenics,…”
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Extracellular Superoxide Dismutase, the Endothelial Basement Membrane, and the WNT Pathway: New Players in Vascular Normalization and Tumor Infiltration by T-Cells by Martínez-Rey, Diego, Carmona-Rodríguez, Lorena, Fernández-Aceñero, María Jesús, Mira, Emilia, Mañes, Santos

“…Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of cancer and the response to immunotherapy. In primary cancers,…”
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T cell costimulation by chemokine receptors by Viola, Antonella, Gómez-Moutón, Concepción, Gri, Giorgia, Martínez-A, Carlos, Molon, Barbara, Lanzavecchia, Antonio, Mañes, Santos, Bettella, Monica

“…Signals mediated by chemokine receptors may compete with T cell receptor stop signals and determine the duration of T cell-antigen-presenting cell…”
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Filamin-A regulates actin-dependent clustering of HIV receptors by Viola, Antonella, Gómez-Moutón, Concepción, Martínez-Prats, Lorena, Ana Lacalle, Rosa, Jiménez-Baranda, Sonia, Martínez-A, Carlos, Mañes, Santos, Dimitrov, Dimiter S, Delgado, Rafael, Rojas, Ana, Mira, Emilia, Valencia, Alfonso

“…Human immunodeficiency virus (HIV)-1 infection requires envelope (Env) glycoprotein gp120-induced clustering of CD4 and coreceptors (CCR5 or CXCR4) on the cell…”
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Molecular Classification of Colorectal Cancer by microRNA Profiling: Correlation with the Consensus Molecular Subtypes (CMS) and Validation of miR-30b Targets by Paz-Cabezas, Mateo, Calvo-López, Tania, Romera-Lopez, Alejandro, Tabas-Madrid, Daniel, Ogando, Jesus, Fernández-Aceñero, María-Jesús, Sastre, Javier, Pascual-Montano, Alberto, Mañes, Santos, Díaz-Rubio, Eduardo, Perez-Villamil, Beatriz

“…Colorectal cancer consensus molecular subtypes (CMSs) are widely accepted and constitutes the basis for patient stratification to improve clinical practice. We…”
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CXCR4-CCR5: A couple modulating T cell functions by Contento, Rita Lucia, Molon, Barbara, Boularan, Cedric, Pozzan, Tullio, Manes, Santos, Marullo, Stefano, Viola, Antonella

“…Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic…”
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The Chemokine Receptor CCR5 Links Memory CD4 + T Cell Metabolism to T Cell Antigen Receptor Nanoclustering by Blanco, Raquel, Gómez de Cedrón, Marta, Gámez-Reche, Laura, Martín-Leal, Ana, González-Martín, Alicia, Lacalle, Rosa A, Ramírez de Molina, Ana, Mañes, Santos

“…The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals…”
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Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement by Lacalle, Rosa Ana, Peregil, Rosa M, Albar, Juan Pablo, Merino, Ernesto, Martínez-A, Carlos, Mérida, Isabel, Mañes, Santos

“…Directional cell movement in response to external chemical gradients requires establishment of front-rear asymmetry, which distinguishes an up-gradient…”
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Age-related oxidative stress confines damage-responsive Bmi1 + cells to perivascular regions in the murine adult heart by Herrero, Diego, Cañón, Susana, Albericio, Guillermo, Carmona, Rosa María, Aguilar, Susana, Mañes, Santos, Bernad, Antonio

“…Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following…”
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A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors by Mira, Emilia, Carmona-Rodríguez, Lorena, Tardáguila, Manuel, Azcoitia, Iñigo, González-Martín, Alicia, Almonacid, Luis, Casas, Josefina, Fabriás, Gemma, Mañes, Santos

“…Beyond their ability to inhibit cholesterol biosynthesis, the statins have pleiotropic effects that include anti-inflammatory and immunomodulatory activities…”
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CHEMOKINE SIGNALING AND FUNCTIONAL RESPONSES: The Role of Receptor Dimerization and TK Pathway Activation by Mellado, Mario, Rodríguez-Frade, José Miguel, Mañes, Santos, Martínez-A, Carlos

“…A broad array of biological responses, including cell polarization, movement, immune and inflammatory responses, and prevention of HIV-1 infection, are…”
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Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC by Arnold, Shanna, Mira, Emilia, Muneer, Sabeeha, Korpanty, Grzegorz, Beck, Adam W, Holloway, Shane E, Mañes, Santos, Brekken, Rolf A

“…Pancreatic adenocarcinoma is characterized by desmoplasia, local invasion, and metastasis. These features are regulated in part by MMP9 and SPARC. To explore…”
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Biomechanical properties of laminins and their impact on cancer progression by Nonnast, Elena, Mira, Emilia, Mañes, Santos

“…Laminins (LMs) constitute a family of heterotrimeric glycoproteins essential for the formation of basement membranes (BM). They act as molecular bridges…”
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The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis by Ruiz-Iglesias, Ainhoa, Mañes, Santos

“…Pyruvate is a key molecule in the metabolic fate of mammalian cells; it is the crossroads from where metabolism proceeds either oxidatively or ends with the…”
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APRIL and BAFF proteins increase proliferation of human adipose-derived stem cells through activation of Erk1/2 MAP kinase by Zonca, Manuela, Mancheño-Corvo, Pablo, DelaRosa, Olga, Mañes, Santos, Büscher, Dirk, Lombardo, Eleuterio, Planelles, Lourdes

“…Human adipose-derived stem cells (hASC) are mesenchymal stem cells with reduced immunogenicity and the ability to modulate immune responses. APRIL and BAFF…”
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Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling by Cabrera, J. Ruben, Sanchez-Pulido, Luis, Rojas, Ana M., Valencia, Alfonso, Mañes, Santos, Naranjo, Jose R., Mellström, Britt

“…The growth arrest-specific gene 1 (Gas1) protein has been proposed to function during development as an inhibitor of growth and a mediator of cell death and is…”
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