Search Results - "Manel Esteller"

Clinical epigenetics: seizing opportunities for translation by Berdasco, María, Esteller, Manel

“…Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in…”
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Lung cancer epigenetics: From knowledge to applications by Duruisseaux, Michaël, Esteller, Manel

“…Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our understanding of the genomics of lung cancer have led to substantial…”
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DNA methylation profiling in the clinic: applications and challenges by Heyn, Holger, Esteller, Manel

“…Key Points Alterations in epigenetic marks — specifically DNA methylation — are an emerging biomarker that may be used in the decision-making process for…”
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RNA–RNA interactions in gene regulation: the coding and noncoding players by Guil, Sonia, Esteller, Manel

“…•A variety of RNAs engage in direct RNA–RNA interactions with regulatory potential.•These multiple interactions are interconnected and create complex cellular…”
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Cis-acting noncoding RNAs: friends and foes by Guil, Sònia, Esteller, Manel

“…The number and types of known functional noncoding RNAs (ncRNAs) has increased considerably over the past few years, and both cis - and trans -acting ncRNAs…”
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Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry by Berdasco, María, Esteller, Manel

“…Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human…”
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The Epitranscriptome of Noncoding RNAs in Cancer by Esteller, Manel, Pandolfi, Pier Paolo

“…The activity of RNA is controlled by different types of post-transcriptional modifications, such as the addition of methyl groups and other chemical and…”
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Writers, readers and erasers of RNA modifications in cancer by Esteve-Puig, Rosaura, Bueno-Costa, Alberto, Esteller, Manel

“…Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by…”
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Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? by Hanly, David J., Esteller, Manel, Berdasco, María

“…Of the diverse array of putative molecular and biological functions assigned to long non-coding RNAs (lncRNAs), one attractive perspective in epigenetic…”
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Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences by Moran, Sebastian, Arribas, Carles, Esteller, Manel

“…DNA methylation is the best known epigenetic mark. Cancer and other pathologies show an altered DNA methylome. However, delivering complete DNA methylation…”
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Bromodomain inhibitors and cancer therapy: From structures to applications by Pérez-Salvia, Montserrat, Esteller, Manel

“…Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes that are "writers," "erasers," or "readers" of histone modification…”
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CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future by Esteller, Manel

“…We have come a long way since the first reports of the existence of aberrant DNA methylation in human cancer. Hypermethylation of CpG islands located in the…”
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Accelerated biological aging in COVID-19 patients by Cao, Xue, Li, Wenjuan, Wang, Ting, Ran, Dongzhi, Davalos, Veronica, Planas-Serra, Laura, Pujol, Aurora, Esteller, Manel, Wang, Xiaolin, Yu, Huichuan

“…Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral…”
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The Contribution of Epigenetics to Cancer Immunotherapy by Villanueva, Lorea, Álvarez-Errico, Damiana, Esteller, Manel

“…Effective anticancer immunotherapy treatments constitute a qualitative leap in cancer management. Nonetheless, not all patients benefit from such therapies…”
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Aberrant DNA methylation as a cancer-inducing mechanism by ESTELLER, Manel

“…Aberrant DNA methylation is the most common molecular lesion of the cancer cell. Neither gene mutations (nucleotide changes, deletions, recombinations) nor…”
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DNA methylation in cancer: From mouse to human and back again by Esteller, Manel

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Epigenetic drugs: More than meets the eye by Esteller, Manel

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The role of histone deacetylases (HDACs) in human cancer by Ropero, Santiago, Esteller, Manel

“…The balance of histone acetylation and deacetylation is an epigenetic layer with a critical role in the regulation of gene expression. Histone acetylation…”
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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies by Urdinguio, Rocio G, PhD, Sanchez-Mut, Jose V, PhD, Esteller, Manel, MD

“…Summary Epigenetic mechanisms such as DNA methylation and modifications to histone proteins regulate high-order DNA structure and gene expression. Aberrant…”
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DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load by Jung, Hyunchul, Kim, Hong Sook, Kim, Jeong Yeon, Sun, Jong-Mu, Ahn, Jin Seok, Ahn, Myung-Ju, Park, Keunchil, Esteller, Manel, Lee, Se-Hoon, Choi, Jung Kyoon

“…Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division…”
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