Search Results - "Manel, Nicolas"

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles by Colombo, Marina, Moita, Catarina, van Niel, Guillaume, Kowal, Joanna, Vigneron, James, Benaroch, Philippe, Manel, Nicolas, Moita, Luis F, Théry, Clotilde, Raposo, Graça

“…Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in…”
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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes by Cerboni, Silvia, Jeremiah, Nadia, Gentili, Matteo, Gehrmann, Ulf, Conrad, Cécile, Stolzenberg, Marie-Claude, Picard, Capucine, Neven, Bénédicte, Fischer, Alain, Amigorena, Sébastian, Rieux-Laucat, Frédéric, Manel, Nicolas

“…Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate…”
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Transmission of innate immune signaling by packaging of cGAMP in viral particles by Gentili, Matteo, Kowal, Joanna, Tkach, Mercedes, Satoh, Takeshi, Lahaye, Xavier, Conrad, Cécile, Boyron, Marilyn, Lombard, Bérangère, Durand, Sylvère, Kroemer, Guido, Loew, Damarys, Dalod, Marc, Théry, Clotilde, Manel, Nicolas

“…Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate…”
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ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death by Raab, M., Gentili, M., de Belly, H., Thiam, H. R., Vargas, P., Jimenez, A. J., Lautenschlaeger, F., Voituriez, Raphaël, Lennon-Duménil, A. M., Manel, N., Piel, M.

“…In eukaryotic cells, the nuclear envelope separates the genomic DNA from the cytoplasmic space and regulates protein trafficking between the two compartments…”
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The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells by Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Conrad, Cécile, Hurbain, Ilse, El Marjou, Ahmed, Lacabaratz, Christine, Lelièvre, Jean-Daniel, Manel, Nicolas

“…HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the…”
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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion by Nader, Guilherme Pedreira de Freitas, Agüera-Gonzalez, Sonia, Routet, Fiona, Gratia, Matthieu, Maurin, Mathieu, Cancila, Valeria, Cadart, Clotilde, Palamidessi, Andrea, Ramos, Rodrigo Nalio, San Roman, Mabel, Gentili, Matteo, Yamada, Ayako, Williart, Alice, Lodillinsky, Catalina, Lagoutte, Emilie, Villard, Catherine, Viovy, Jean-Louis, Tripodo, Claudio, Galon, Jérôme, Scita, Giorgio, Manel, Nicolas, Chavrier, Philippe, Piel, Matthieu

“…Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically…”
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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation by Lahaye, Xavier, Gentili, Matteo, Silvin, Aymeric, Conrad, Cécile, Picard, Léa, Jouve, Mabel, Zueva, Elina, Maurin, Mathieu, Nadalin, Francesca, Knott, Gavin J., Zhao, Baoyu, Du, Fenglei, Rio, Marlène, Amiel, Jeanne, Fox, Archa H., Li, Pingwei, Etienne, Lucie, Bond, Charles S., Colleaux, Laurence, Manel, Nicolas

“…Detection of viruses by innate immune sensors induces protective antiviral immunity. The viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for…”
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Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling by Lepelley, Alice, Martin-Niclós, Maria José, Le Bihan, Melvin, Marsh, Joseph A, Uggenti, Carolina, Rice, Gillian I, Bondet, Vincent, Duffy, Darragh, Hertzog, Jonny, Rehwinkel, Jan, Amselem, Serge, Boulisfane-El Khalifi, Siham, Brennan, Mary, Carter, Edwin, Chatenoud, Lucienne, Chhun, Stéphanie, Coulomb l'Hermine, Aurore, Depp, Marine, Legendre, Marie, Mackenzie, Karen J, Marey, Jonathan, McDougall, Catherine, McKenzie, Kathryn J, Molina, Thierry Jo, Neven, Bénédicte, Seabra, Luis, Thumerelle, Caroline, Wislez, Marie, Nathan, Nadia, Manel, Nicolas, Crow, Yanick J, Frémond, Marie-Louise

“…Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome overlapping clinically with type I IFN-mediated disease due to…”
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A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells by Littman, Dan R, Manel, Nicolas, Hogstad, Brandon, Wang, Yaming, Levy, David E, Unutmaz, Derya

“…Dendritic cells serve a key function in host defence, linking innate detection of microbes to activation of pathogen-specific adaptive immune responses…”
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Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS by Gratia, Matthieu, Rodero, Mathieu P, Conrad, Cécile, Bou Samra, Elias, Maurin, Mathieu, Rice, Gillian I, Duffy, Darragh, Revy, Patrick, Petit, Florence, Dale, Russell C, Crow, Yanick J, Amor-Gueret, Mounira, Manel, Nicolas

“…Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of…”
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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria by Ivanov, Ivaylo I., Atarashi, Koji, Manel, Nicolas, Brodie, Eoin L., Shima, Tatsuichiro, Karaoz, Ulas, Wei, Dongguang, Goldfarb, Katherine C., Santee, Clark A., Lynch, Susan V., Tanoue, Takeshi, Imaoka, Akemi, Itoh, Kikuji, Takeda, Kiyoshi, Umesaki, Yoshinori, Honda, Kenya, Littman, Dan R.

“…The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship…”
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Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes by Verrier, Eloi R., Yim, Seung‐Ae, Heydmann, Laura, El Saghire, Houssein, Bach, Charlotte, Turon‐Lagot, Vincent, Mailly, Laurent, Durand, Sarah C., Lucifora, Julie, Durantel, David, Pessaux, Patrick, Manel, Nicolas, Hirsch, Ivan, Zeisel, Mirjam B., Pochet, Nathalie, Schuster, Catherine, Baumert, Thomas F.

“…Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms of viral genome sensing and the…”
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Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus by Cocozza, Federico, Névo, Nathalie, Piovesana, Ester, Lahaye, Xavier, Buchrieser, Julian, Schwartz, Olivier, Manel, Nicolas, Tkach, Mercedes, Théry, Clotilde, Martin‐Jaular, Lorena

“…SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion…”
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A genetic memory initiates the epigenetic loop necessary to preserve centromere position by Hoffmann, Sebastian, Izquierdo, Helena M, Gamba, Riccardo, Chardon, Florian, Dumont, Marie, Keizer, Veer, Hervé, Solène, McNulty, Shannon M, Sullivan, Beth A, Manel, Nicolas, Fachinetti, Daniele

“…Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin enriched with the histone H3 variant CENP‐A, the epigenetic mark that…”
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A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway by Zablocki-Thomas, Laurent, Menzies, Sam A, Lehner, Paul J, Manel, Nicolas, Benaroch, Philippe

“…A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal…”
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Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics by Bhargava, Anvita, Williart, Alice, Maurin, Mathieu, Davidson, Patricia M., Jouve, Mabel, Piel, Matthieu, Lahaye, Xavier, Manel, Nicolas

“…The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but the role of nuclear envelope proteins in this process is incompletely…”
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Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells by Eichholz, Karsten, Bru, Thierry, Tran, Thi Thu Phuong, Fernandes, Paulo, Welles, Hugh, Mennechet, Franck J D, Manel, Nicolas, Alves, Paula, Perreau, Matthieu, Kremer, Eric J

“…Human adenoviruses (HAdVs) are nonenveloped proteinaceous particles containing a linear double-stranded DNA genome. HAdVs cause a spectrum of pathologies in…”
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Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans by Chauvin, Samuel D., Ando, Shoichiro, Holley, Joe A., Sugie, Atsushi, Zhao, Fang R., Poddar, Subhajit, Kato, Rei, Miner, Cathrine A., Nitta, Yohei, Krishnamurthy, Siddharth R., Saito, Rie, Ning, Yue, Hatano, Yuya, Kitahara, Sho, Koide, Shin, Stinson, W. Alexander, Fu, Jiayuan, Surve, Nehalee, Kumble, Lindsay, Qian, Wei, Polishchuk, Oleksiy, Andhey, Prabhakar S., Chiang, Cindy, Liu, Guanqun, Colombeau, Ludovic, Rodriguez, Raphaël, Manel, Nicolas, Kakita, Akiyoshi, Artyomov, Maxim N., Schultz, David C., Coates, P. Toby, Roberson, Elisha D. O., Belkaid, Yasmine, Greenberg, Roger A., Cherry, Sara, Gack, Michaela U., Hardy, Tristan, Onodera, Osamu, Kato, Taisuke, Miner, Jonathan J.

“…Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of…”
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Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation by Solier, Stéphanie, Müller, Sebastian, Cañeque, Tatiana, Versini, Antoine, Baron, Leeroy, Gestraud, Pierre, Servant, Nicolas, Emam, Laila, Mansart, Arnaud, Pantoș, Gheorghe Dan, Gandon, Vincent, Sencio, Valentin, Robil, Cyril, Trottein, François, Bègue, Anne-Laure, Salmon, Hélène, Durand, Sylvère, Wu, Ting-Di, Manel, Nicolas, Puisieux, Alain, Dawson, Mark A., Watson, Sarah, Kroemer, Guido, Annane, Djillali, Rodriguez, Raphaël

“…Inflammation is a complex physiological process triggered in response to harmful stimuli. It involves specialized cells of the immune system able to clear…”
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Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C by Montel-Hagen, Amélie, Kinet, Sandrina, Manel, Nicolas, Mongellaz, Cédric, Prohaska, Rainer, Battini, Jean-Luc, Delaunay, Jean, Sitbon, Marc, Taylor, Naomi

“…Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during…”
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