Search Results - "Mandl, Adel"

Puma Deletion Delays Cardiac Dysfunction in Murine Heart Failure Models Through Attenuation of Apoptosis by MANDL, Adel, LY HUONG PHAM, TOTH, Kalman, ZAMBETTI, Gerald, ERHARDT, Peter

“…Puma (p53-upregulated modulator of apoptosis) is a proapoptotic Bcl-2 family protein that serves as a general sensor in response to pathological apoptotic…”
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Endoplasmic reticulum stress as a novel therapeutic target in heart diseases by Toth, Ambrus, Nickson, Philip, Mandl, Adel, Bannister, Mark L, Toth, Kalman, Erhardt, Peter

“…The endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis and folding of proteins as well as calcium storage and signaling…”
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Serum Withdrawal-Induced Accumulation of Phosphoinositide 3-Kinase Lipids in Differentiating 3T3-L6 Myoblasts: Distinct Roles for Ship2 and PTEN by Mandl, Adel, Sarkes, Deborah, Carricaburu, Valerie, Jung, Vanessa, Rameh, Lucia

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma by Tepede, Aisha A, Welch, James, Lee, Maya, Mandl, Adel, Agarwal, Sunita K, Nilubol, Naris, Patel, Dhaval, Cochran, Craig, Simonds, William F, Weinstein, Lee S, Jha, Abhishek, Millo, Corina, Pacak, Karel, Blau, Jenny E

“…Summary Pheochromocytoma (PHEO) in multiple endocrine neoplasia type 1 (MEN1) is extremely rare. The incidence is reported as less than 2%. We report a case of…”
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Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18F-FDOPA PET Imaging by Abdul Sater, Zahraa, Jha, Abhishek, Mandl, Adel, Mangelen, Sheila K., Carrasquillo, Jorge A., Ling, Alexander, Gonzales, Melissa K., Lopes Abath Neto, Osorio, Miettinen, Markku, Adams, Karen T., Nockel, Pavel, El Lakis, Mustapha, Pacak, Karel

“…A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with…”
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Role of bromodomain and extraterminal (BET) proteins in prostate cancer by Mandl, Adel, Markowski, Mark C, Carducci, Michael A, Antonarakis, Emmanuel S

“…The bromodomain and extraterminal (BET) family of proteins are epigenetic readers of acetylated histones and are critical activators of oncogenic networks…”
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Muscadine grape skin extract in men with biochemically recurrent prostate cancer: A phase III, randomized, multicenter, placebo-controlled clinical trial by Mandl, Adel, Zahurak, Marianna, Sfanos, Karen, Metri, Nicole, Maughan, Benjamin L., Taplin, Mary-Ellen, Shore, Neal D., McKay, Rana R., Reichert, Zachery R, Szmulewitz, Russell Zelig, Kessler, Elizabeth R., Heath, Elisabeth I., Dreicer, Robert, Stein, Cy Aaron, Marshall, Catherine Handy, Markowski, Mark Christopher, Denmeade, Samuel R., Antonarakis, Emmanuel S., Carducci, Michael Anthony, Paller, Channing Judith

“…329 Background: Many patients prefer to delay endocrine therapy for biochemically recurrent prostate cancer (BRCPC) due to associated adverse effects,…”
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Colonic pseudo-obstruction in a patient with Sheehan’s syndrome by Kaur, Navneet, Schubart, Ulrich, Mandl, Adel

“…A 56-year-old woman with a history of hypothyroidism and chronic constipation presented with an acute abdomen due to colonic pseudo-obstruction. Thyroid…”
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c-MET inhibition: novel treatment for sporadic and MEN1-associated GEP NETs by Lee, Maya Elena, Tepede, Aisha Aderayo, Mandl, Adel, Weinstein, Lee Scott, del Rivero, Jaydira, Agarwal, Sunita K, Blau, Jenny E

“…Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell…”
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Pheochromocytoma and Paraganglioma Patients With Poor Survival Often Show Brown Adipose Tissue Activation by Abdul Sater, Zahraa, Jha, Abhishek, Hamimi, Ahmed, Mandl, Adel, Hartley, Iris R, Gubbi, Sriram, Patel, Mayank, Gonzales, Melissa, Taïeb, David, Civelek, Ali Cahid, Gharib, Ahmed M, Auh, Sungyoung, O’Mara, Alana E, Pacak, Karel, Cypess, Aaron M

“…Abstract Context Pheochromocytomas/paragangliomas (PPGLs) are neuroendocrine tumors that can secrete norepinephrine (NE). Brown adipose tissue (BAT) activation…”
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SUN-437 Central Adrenal Insufficiency Unmasked by Pregnancy by Araque, Katherine, Mandl, Adel, Nieman, Lynnette

“…Recognition and prompt treatment of adrenal insufficiency (AI) during pregnancy are important to prevent maternal adrenal crisis and/or fetal intrauterine…”
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Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models by Jasmine, Sumer, Mandl, Adel, Krueger, Timothy E. G., Dalrymple, Susan L., Antony, Lizamma, Dias, Jennifer, Celatka, Cassandra A., Tapper, Amy E., Kleppe, Maria, Kanayama, Mayuko, Jing, Yuezhou, Speranzini, Valentina, Wang, Yuzhuo Z., Luo, Jun, Trock, Bruce J., Denmeade, Samuel R., Carducci, Michael A., Mattevi, Andrea, Rienhoff, Hugh Y., Isaacs, John T., Brennen, W. Nathaniel

“…Introduction Lysine‐specific demethylase 1 (LSD1) is emerging as a critical mediator of tumor progression in metastatic castration‐resistant prostate cancer…”
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Patients With MEN1 Are at an Increased Risk for Venous Thromboembolism by Lee, Maya E, Ortega-Sustache, Yashira M, Agarwal, Sunita K, Tepede, Aisha, Welch, James, Mandl, Adel, Bansal, Rashika, Tirosh, Amit, Piaggi, Paolo, Cochran, Craig, Simonds, William F, Weinstein, Lee S, Blau, Jenny E

“…Abstract Background Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder predisposing the development of multiple functional and…”
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Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus by Mandl, Adel, Welch, James M, Kapoor, Gayathri, Parekh, Vaishali I, Schrump, David S, Ripley, R Taylor, Walter, Mary F, Del Rivero, Jaydira, Jha, Smita, Simonds, William F, Jensen, Robert T, Weinstein, Lee S, Blau, Jenny E, Agarwal, Sunita K

“…Patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome carry germline heterozygous loss-of-function mutations in the MEN1 gene which predisposes…”
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Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor by Mandl, Adel, Burbelo, Peter D, Di Pasquale, Giovanni, Tay, You Sher, Welch, James, Lionakis, Michail S, Rosenzweig, Sergio D, Waldman, Meryl A, Warner, Blake M, Walitt, Brian, Collins, Michael T, Balow, James E, Chiorini, John A, Simonds, William F, Agarwal, Sunita K, Blau, Jenny E, Weinstein, Lee S

“…We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which…”
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Abstract 3232: LSD1 inhibition transcriptionally reprograms neuroendocrine prostate cancer exposing unique therapeutic vulnerabilities by Jasmine, Sumer M., Mandl, Adel, Dalrymple, Susan L., Kim, Sunghyun, Dias, Jennifer, Kleppe, Maria, Celatka, Cassandra, Tapper, Amy, Coleman, Ilsa, Nelson, Peter, Rienhoff, Hugh, Denmeade, Samuel R., Brennen, W. Nathaniel

“…Abstract Therapeutics have been developed to target castration-resistant prostate cancer (CRPC) classified as adenocarcinoma (CRPC-Adeno). However, an…”
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High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase 2 Trial by Paller, Channing J, Zahurak, Marianna L, Mandl, Adel, Metri, Nicole A, Lalji, Aliya, Heath, Elisabeth, Kelly, William K, Hoimes, Christopher, Barata, Pedro, Taksey, Jason, Garrison, Dominique A, Patra, Kartick, Milne, Ginger L, Anders, Nicole M, Nauroth, Julie M, Durham, Jennifer N, Marshall, Catherine H, Markowski, Mark C, Eisenberger, Mario A, Antonarakis, Emmanuel S, Carducci, Michael A, Denmeade, Samuel R, Levine, Mark

“…High-dose intravenous vitamin C(HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but…”
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c-MET Inhibition: Novel Treatment for Sporadic and MEN1-associated GEP NET by Lee, Maya Elena, Tepede, Aisha Aderayo, Mandl, Adel, Weinstein, Lee Scott, Del Rivero, Jaydira, Agarwal, Sunita K, Blau, Jenny E

“…Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell…”
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MON-321 Metastatic Melanoma with Unknown Primary Site in a Patient with Multiple Endocrine Neoplasia Type 1 by Kamilaris, Crystal, Mandl, Adel, Simonds, William, Weinstein, Lee, Agarwal, Sunita, Blau, Jenny

“…Background: MEN1 is a rare hereditary tumor syndrome caused by germline inactivating mutations of the tumor suppressor gene MEN1 and is characterized by a…”
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Thymoma and Not Just Thymic Carcinoid Can Be Associated With Multiple Endocrine Neoplasia Type 1 by Graf, Akua, Welch, James, Agarwal, Sunita, Cochran, Craig, Parekh, Vaishali, Simonds, William F, Weinstein, Lee, Jha, Smita, Blau, Jenny, Schrump, David, del Rivero, Jaydira, Mandl, Adel

“…Abstract Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumor syndrome with autosomal dominant inheritance. Thymic neuroendocrine…”
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