Search Results - "Mandil, Hassan"
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Protein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1
Published in British journal of cancer (01-01-2020)“…Background Protein kinase D1 (PKD1) is a serine–threonine kinase that regulates various functions within the cell. Herein, we report the significance of PKD1…”
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2
Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents
Published in Genes & diseases (01-09-2017)“…Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous…”
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Correlation of circulating miRNA-33a and miRNA-122 with lipid metabolism among Egyptian patients with metabolic syndrome
Published in Journal of Genetic Engineering and Biotechnology (05-10-2021)“…Background Metabolic syndrome is defined as a group of interrelated biochemical, clinical, and metabolic factors that directly increase the risk of…”
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Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer
Published in ACS omega (24-10-2023)“…Aberrant regulation of β-catenin signaling is strongly linked with cancer proliferation, invasion, migration, and metastasis, thus, small molecules that can…”
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Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore
Published in Communications biology (04-11-2022)“…There is increasing evidence suggesting the role of microbiome alterations in relation to pancreatic adenocarcinoma and tumor immune functionality. However,…”
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Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients
Published in Journal of Genetic Engineering and Biotechnology (03-08-2021)“…Background Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune…”
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Genetic susceptibility for insulin resistance among Egyptian women
Published in Journal of Genetic Engineering and Biotechnology (01-06-2016)“…The fat mass and obesity-associated (FTO) gene is recognized as the strongest predictor of obesity related traits such as insulin sensitivity and plasma…”
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Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians
Published in Molecular biology reports (01-07-2021)“…Background A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic…”
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Ancient DNA study of the remains of putative infanticide victims from the Yewden Roman villa site at Hambleden, England
Published in Journal of archaeological science (01-03-2014)“…Previous analysis of the perinatal infant burials from Romano-British Yewden villa, Hambleden, indicated the practice of infanticide at that site. We attempted…”
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10
Sex identification of ancient DNA samples using a microfluidic device
Published in Journal of archaeological science (01-01-2013)“…A microfluidic device has been developed for the sex identification of ancient DNA samples and works by manipulating liquids within an environment of…”
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Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Background: Docetaxel (DTX) is an FDA approved drug for the treatment of advanced prostate cancer (PrCa). However, chemo-resistance and toxicity…”
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Next-generation paclitaxel-nanoparticle formulation for pancreatic cancer treatment
Published in Nanomedicine (01-08-2019)“…Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they…”
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Abstract 5777: Ormeloxifene augments the therapeutic response of enzalutamide via targeting androgen receptor splice variant 7
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Enzalutamide (ENZ) is a second generation anti-androgen drug in clinical use for the treatment of advanced prostate cancer (PrCa). Use of ENZ has some…”
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Abstract LB-011: Novel nano-formulation of paclitaxel for pancreatic cancer therapy
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus,…”
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Abstract 4809: Bromo-ormeloxifene inhibits epithelial mesenchymal transition via targeting β-catenin signaling pathways in cervical cancer cells
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Background: Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have…”
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Abstract 102: Ferrichrome suppresses pancreatic tumor growth via targeting TAMs and enhancing CD8+ T-cells infiltration
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Background: Pancreatic cancer (PanCa) is one of the most lethal malignancy with a very poor survival rate in patients due to inadequate treatment…”
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Ormeloxifene nanotherapy for cervical cancer treatment
Published in International journal of nanomedicine (01-09-2019)“…Cervical cancer (CxCa) ranks as the fourth most prevalent women-related cancer worldwide. Therefore, there is a crucial need to develop newer treatment…”
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The odds of having obesity in Egyptian children with autism spectrum disorders is higher than stunting compared to healthy developing peers: a national survey
Published in BMC pediatrics (20-07-2024)“…The nutritional status and growth of children with Autism spectrum disorders (ASD) is influenced significantly by two factors; food selectivity behaviors due…”
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Genetic affiliations within a 19th century burial ground at Darwen, Lancashire, UK
Published in Journal of archaeological science, reports (01-04-2019)Get full text
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Insights from ancient DNA analysis of Egyptian human mummies: clues to disease and kinship
Published in Human molecular genetics (26-04-2021)“…Abstract The molecular Egyptology field started in the mid-eighties with the first publication on the ancient DNA (aDNA) analysis of an Egyptian mummy. Egypt…”
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