Search Results - "Mandeville, Joseph"

IRON fMRI measurements of CBV and implications for BOLD signal by Mandeville, Joseph B.

“…Changes in cerebral blood volume (CBV) and blood magnetization each induce changes in the transverse relaxation rate of MRI signal that are associated with…”
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Behavioral and Anatomical Consequences of Early versus Late Symbol Training in Macaques by Srihasam, Krishna, Mandeville, Joseph B., Morocz, Istvan A., Sullivan, Kevin J., Livingstone, Margaret S.

“…Distinct brain regions, reproducible from one person to the next, are specialized for processing different kinds of human expertise, such as face…”
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Amphetamine pretreatment blunts dopamine-induced D2/D3-receptor occupancy by an arrestin-mediated mechanism: A PET study in internalization compromised mice by Mandeville, Joseph B., Weigand-Whittier, Jonah, Wey, Hsiao-Ying, Chen, Yin-Ching I.

“…•PET was employed in β-arrestin-2 knock-out mice to study receptor internalization.•[11C]Raclopride was used to study D2/D3 receptor occupancy and binding…”
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Rodent Cerebral Blood Volume (CBV) changes during hypercapnia observed using Magnetic Particle Imaging (MPI) detection by Cooley, Clarissa Zimmerman, Mandeville, Joseph B., Mason, Erica E., Mandeville, Emiri T., Wald, Lawrence L.

“…Magnetic Particle Imaging (MPI) is a rapidly developing imaging modality that directly measures and maps the concentration of injected superparamagnetic iron…”
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Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI by Sander, Christin Y, Hooker, Jacob M, Catana, Ciprian, Rosen, Bruce R, Mandeville, Joseph B

“…This study investigated the dynamics of dopamine receptor desensitization and internalization, thereby proposing a new technique for non-invasive, in vivo…”
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A receptor-based model for dopamine-induced fMRI signal by Mandeville, Joseph B., Sander, Christin Y.M., Jenkins, Bruce G., Hooker, Jacob M., Catana, Ciprian, Vanduffel, Wim, Alpert, Nathaniel M., Rosen, Bruce R., Normandin, Marc D.

“…This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in…”
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Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI by Sander, Christin Y., Hooker, Jacob M., Catana, Ciprian, Normandin, Marc D., Alpert, Nathaniel M., Knudsen, Gitte M., Vanduffel, Wim, Rosen, Bruce R., Mandeville, Joseph B.

“…This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the…”
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Dynamic functional imaging of brain glucose utilization using fPET-FDG by Villien, Marjorie, Wey, Hsiao-Ying, Mandeville, Joseph B., Catana, Ciprian, Polimeni, Jonathan R., Sander, Christin Y., Zürcher, Nicole R., Chonde, Daniel B., Fowler, Joanna S., Rosen, Bruce R., Hooker, Jacob M.

“…Glucose is the principal source of energy for the brain and yet the dynamic response of glucose utilization to changes in brain activity is still not fully…”
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Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice by Miyamoto, Nobukazu, Maki, Takakuni, Pham, Loc-Duyen D, Hayakawa, Kazuhide, Seo, Ji Hae, Mandeville, Emiri T, Mandeville, Joseph B, Kim, Kyu-Won, Lo, Eng H, Arai, Ken

“…BACKGROUND AND PURPOSE—White matter injury caused by cerebral hypoperfusion may contribute to the pathophysiology of vascular dementia and stroke, but the…”
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Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal by Tian, Peifang, Teng, Ivan C., May, Larry D., Kurz, Ronald, Lu, Kun, Scadeng, Miriam, Hillman, Elizabeth M. C., De Crespigny, Alex J., D'Arceuil, Helen E., Mandeville, Joseph B., Marota, John J. A., Rosen, Bruce R., Liu, Thomas T., Boas, David A., Buxton, Richard B., Dale, Anders M., Devor, Anna, Logothetis, Nikos K.

“…Changes in neuronal activity are accompanied by the release of vasoactive mediators that cause microscopic dilation and constriction of the cerebral…”
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Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Levine, Michael A, Mandeville, Joseph B, Calabro, Finnegan, Izquierdo-Garcia, David, Chonde, Daniel B, Chen, Kevin T, Hong, Inki, Price, Julie C, Luna, Beatriz, Catana, Ciprian

“…Compartmental modeling analysis of 11C-raclopride (RAC) PET data can be used to measure the dopaminergic response to intra-scan behavioral tasks. Bias in…”
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Translational MR Neuroimaging of Stroke and Recovery by Mandeville, Emiri T., Ayata, Cenk, Zheng, Yi, Mandeville, Joseph B.

“…Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and…”
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Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation by Sander, Christin Y, Mandeville, Joseph B, Wey, Hsiao-Ying, Catana, Ciprian, Hooker, Jacob M, Rosen, Bruce R

“…The potential effects of changes in blood flow on the delivery and washout of radiotracers has been an ongoing question in PET bolus injection studies. This…”
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Beneficial Effects of Nitric Oxide on Outcomes after Cardiac Arrest and Cardiopulmonary Resuscitation in Hypothermia-treated Mice by KIDA, Kotaro, SHIROZU, Kazuhiro, BINGLAN YU, MANDEVILLE, Joseph B, BLOCH, Kenneth D, ICHINOSE, Fumito

“…Therapeutic hypothermia (TH) improves neurological outcomes after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Although nitric oxide prevents…”
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A reference tissue forward model for improved PET accuracy using within-scan displacement studies by Mandeville, Joseph B, Levine, Michael A, Arsenault, John T, Vanduffel, Wim, Rosen, Bruce R, Sander, Christin Y

“…We report a novel forward-model implementation of the full reference tissue model (fFTRM) that addresses the fast-exchange approximation employed by the…”
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Functional magnetic particle imaging (fMPI) of cerebrovascular changes in the rat brain during hypercapnia by Mason, Erica E, Mattingly, Eli, Herb, Konstantin, Cauley, Stephen F, Śliwiak, Monika, Drago, John M, Graeser, Matthias, Mandeville, Emiri T, Mandeville, Joseph B, Wald, Lawrence L

“…Non-invasive functional brain imaging modalities are limited in number, each with its own complex trade-offs between sensitivity, spatial and temporal…”
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Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases by Mandeville, Emiri T., Li, Wenlu, Quinto-Alemany, David, Zhang, Fang, Esposito, Elga, Nakano, Takafumi, Mandeville, Joseph B., Lee, Janice, Park, Ji Hyun, Arai, Ken, Waeber, Christian, Lizasoain, Ignacio, Moro, María Ángeles, Lo, Eng H.

“…It has been reported that the S1P (sphingosine 1-phosphate) receptor modulator fingolimod reduces infarction in rodent models of stroke. Recent studies have…”
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Visual Field Map Clusters in Macaque Extrastriate Visual Cortex by Kolster, Hauke, Mandeville, Joseph B, Arsenault, John T, Ekstrom, Leeland B, Wald, Lawrence L, Vanduffel, Wim

“…The macaque visual cortex contains >30 different functional visual areas, yet surprisingly little is known about the underlying organizational principles that…”
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A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke by Lyden, Patrick D, Diniz, Márcio A, Bosetti, Francesca, Lamb, Jessica, Nagarkatti, Karisma A, Rogatko, André, Kim, Sungjin, Cabeen, Ryan P, Koenig, James I, Akhter, Kazi, Arbab, Ali S, Avery, Brooklyn D, Beatty, Hannah E, Bibic, Adnan, Cao, Suyi, Simoes Braga Boisserand, Ligia, Chamorro, Angel, Chauhan, Anjali, Diaz-Perez, Sebastian, Dhandapani, Krishnan, Dhanesha, Nirav, Goh, Andrew, Herman, Alison L, Hyder, Fahmeed, Imai, Takahiko, Johnson, Conor W, Khan, Mohammad B, Kamat, Pradip, Karuppagounder, Senthilkumar S, Kumskova, Mariia, Mihailovic, Jelena M, Mandeville, Joseph B, Morais, Andreia, Patel, Rakesh B, Sanganahalli, Basavaraju G, Smith, Cameron, Shi, Yanrong, Sutariya, Brijesh, Thedens, Daniel, Qin, Tao, Velazquez, Sofia E, Aronowski, Jaroslaw, Ayata, Cenk, Chauhan, Anil K, Leira, Enrique C, Hess, David C, Koehler, Raymond C, McCullough, Louise D, Sansing, Lauren H

“…Human diseases may be modeled in animals to allow preclinical assessment of putative new clinical interventions. Recent, highly publicized failures of large…”
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Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice by MINAMISHIMA, Shizuka, KIDA, Kotaro, LIU, Christina H, BLOCH, Kenneth D, ICHINOSE, Fumito, TOKUDA, Kentaro, HUIFANG WANG, SIPS, Patrick Y, KOSUGI, Shizuko, MANDEVILLE, Joseph B, BUYS, Emmanuel S, BROUCKAERT, Peter, LIU, Philip K

“…Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in…”
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