Search Results - "Mandel, Thomas"

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding by Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali

“…Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the…”
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Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1 by Ayres Pereira, Marina, Mandel Clausen, Thomas, Pehrson, Caroline, Mao, Yang, Resende, Mafalda, Daugaard, Mads, Riis Kristensen, Anders, Spliid, Charlotte, Mathiesen, Line, E Knudsen, Lisbeth, Damm, Peter, G Theander, Thor, R Hansson, Stefan, A Nielsen, Morten, Salanti, Ali

“…During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus. The…”
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Beware, commercial chondroitinases vary in activity and substrate specificity by Spliid, Charlotte B, Toledo, Alejandro Gomez, Salanti, Ali, Esko, Jeffrey D, Clausen, Thomas Mandel

“…Chondroitin sulfate (CS)and dermatan sulfate (DS) are negatively charged polysaccharides found abundantly in animal tissue and have been extensively described…”
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Identification of global inhibitors of cellular glycosylation by Sørensen, Daniel Madriz, Büll, Christian, Madsen, Thomas D., Lira-Navarrete, Erandi, Clausen, Thomas Mandel, Clark, Alex E., Garretson, Aaron F., Karlsson, Richard, Pijnenborg, Johan F. A., Yin, Xin, Miller, Rebecca L., Chanda, Sumit K., Boltje, Thomas J., Schjoldager, Katrine T., Vakhrushev, Sergey Y., Halim, Adnan, Esko, Jeffrey D., Carlin, Aaron F., Hurtado-Guerrero, Ramon, Weigert, Roberto, Clausen, Henrik, Narimatsu, Yoshiki

“…Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors…”
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The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility by Spliid, Charlotte B., Toledo, Alejandro Gomez, Sanderson, Patience, Mao, Yang, Gatto, Francesco, Gustavsson, Tobias, Choudhary, Swati, Saldanha, Ana L., Vogelsang, Rasmus P., Gögenur, Ismail, Theander, Thor G., Leach, Franklin E., Amster, I. Jonathan, Esko, Jeffrey D., Salanti, Ali, Clausen, Thomas Mandel

“…Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. Recombinant…”
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Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer by Al-Nakouzi, Nader, Wang, Chris Kedong, Oo, Htoo Zarni, Nelepcu, Irina, Lallous, Nada, Spliid, Charlotte B., Khazamipour, Nastaran, Lo, Joey, Truong, Sarah, Collins, Colin, Hui, Desmond, Esfandnia, Shaghayegh, Adomat, Hans, Clausen, Thomas Mandel, Gustavsson, Tobias, Choudhary, Swati, Dagil, Robert, Corey, Eva, Wang, Yuzhuo, Chauchereau, Anne, Fazli, Ladan, Esko, Jeffrey D., Salanti, Ali, Nelson, Peter S., Gleave, Martin E., Daugaard, Mads

“…Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor…”
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Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility by Clausen, Thomas Mandel, Pereira, Marina Ayres, Al Nakouzi, Nader, Oo, Htoo Zarni, Agerbæk, Mette Ø, Lee, Sherry, Ørum-Madsen, Maj Sofie, Kristensen, Anders Riis, El-Naggar, Amal, Grandgenett, Paul M, Grem, Jean L, Hollingsworth, Michael A, Holst, Peter J, Theander, Thor, Sorensen, Poul H, Daugaard, Mads, Salanti, Ali

“…Many tumors express proteoglycans modified with oncofetal chondroitin sulfate glycosaminoglycan chains (ofCS), which are normally restricted to the placenta…”
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Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia by Dietrich, Sascha, Hüllein, Jennifer, Hundemer, Michael, Lehners, Nicola, Jethwa, Alexander, Capper, David, Acker, Till, Garvalov, Boyan K, Andrulis, Mindaugas, Blume, Carolin, Schulte, Christoph, Mandel, Thomas, Meissner, Julia, Fröhling, Stefan, von Kalle, Christof, Glimm, Hanno, Ho, Anthony D, Zenz, Thorsten

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Noninvasive detection of any-stage cancer using free glycosaminoglycans by Bratulic, Sinisa, Limeta, Angelo, Dabestani, Saeed, Birgisson, Helgi, Enblad, Gunilla, Stålberg, Karin, Hesselager, Göran, Häggman, Michael, Höglund, Martin, Simonson, Oscar E, Stålberg, Peter, Lindman, Henrik, Bång-Rudenstam, Anna, Ekstrand, Matias, Kumar, Gunjan, Cavarretta, Ilaria, Alfano, Massimo, Pellegrino, Francesco, Mandel-Clausen, Thomas, Salanti, Ali, Maccari, Francesca, Galeotti, Fabio, Volpi, Nicola, Daugaard, Mads, Belting, Mattias, Lundstam, Sven, Stierner, Ulrika, Nyman, Jan, Bergman, Bengt, Edqvist, Per-Henrik, Levin, Max, Salonia, Andrea, Kjölhede, Henrik, Jonasch, Eric, Nielsen, Jens, Gatto, Francesco

“…Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic biomarkers can noninvasively diagnose cancers. However, validation…”
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CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches by Tang, Jiajia, Zheng, Quan, Wang, Qi, Zhao, Yaru, Ananthanarayanan, Preeta, Reina, Chiara, Šabanović, Berina, Jiang, Ke, Yang, Ming-Hsin, Meny, Clara Csilla, Wang, Huimin, Agerbaek, Mette Ø., Clausen, Thomas Mandel, Gustavsson, Tobias, Wen, Chenlei, Borghi, Felice, Mellano, Alfredo, Fenocchio, Elisabetta, Gregorc, Vanesa, Sapino, Anna, Theander, Thor G., Fu, Da, Aicher, Alexandra, Salanti, Ali, Shen, Baiyong, Heeschen, Christopher

“…Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that…”
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Alteration of Neuropilin‑1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth by Painter, Chelsea D., Sankaranarayanan, Nehru Viji, Nagarajan, Balaji, Mandel Clausen, Thomas, West, Alan M.V., Setiawan, Nicollette J., Park, Jeeyoung, Porell, Ryan N., Bartels, Phillip L., Sandoval, Daniel R., Vasquez, Gabriel J., Chute, John P., Godula, Kamil, Vander Kooi, Craig W., Gordts, Philip L.S.M., Corbett, Kevin D., Termini, Christina M., Desai, Umesh R., Esko, Jeffrey D.

“…Neuropilin-1 acts as a coreceptor with vascular endothelial growth factor receptors to facilitate binding of its ligand, vascular endothelial growth factor…”
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A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine by Clausen, Thomas Mandel, Kumar, Gunjan, Ibsen, Emilie K., Ørum-Madsen, Maj S., Hurtado-Coll, Antonio, Gustavsson, Tobias, Agerbæk, Mette Ø., Gatto, Francesco, Todenhöfer, Tilman, Basso, Umberto, Knowles, Margaret A., Sanchez-Carbayo, Marta, Salanti, Ali, Black, Peter C., Daugaard, Mads

“…Proteoglycans in bladder tumors are modified with a distinct oncofetal chondroitin sulfate (ofCS) glycosaminoglycan that is normally restricted to placental…”
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Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting by Clausen, Thomas Mandel, Pereira, Marina Ayres, Oo, Htoo Zarni, Resende, Mafalda, Gustavson, Tobias, Mao, Yang, Sugiura, Nobuo, Liew, Janet, Fazli, Ladan, Theander, Thor G, Daugaard, Mads, Salanti, Ali

“…In clinical oncology, diagnosis and evaluation of optimal treatment strategies are mostly based on histopathological examination combined with…”
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 by Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Perrett, Hailee R., Painter, Chelsea D., Narayanan, Anoop, Majowicz, Sydney A., Kwong, Elizabeth M., McVicar, Rachael N., Thacker, Bryan E., Glass, Charles A., Yang, Zhang, Torres, Jonathan L., Golden, Gregory J., Bartels, Phillip L., Porell, Ryan N., Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M., Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Chanda, Sumit K., Schmidt, Aaron G., Godula, Kamil, Leibel, Sandra L., Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.

“…We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding…”
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Structural Characterization of the Chondroitin Sulfate motif binding to VAR2CSA in Placenta and Cancer by Spliid, Charlotte Bredo, Toledo, Alejandro Gomez, Esko, Jeffrey, Clausen, Thomas Mandel

“…Malaria parasites have evolved to express certain proteins called VAR2CSA on the surface of infected erythrocytes. This allows them to adhere to unique…”
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SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling by Biering, Scott B., Gomes de Sousa, Francielle Tramontini, Tjang, Laurentia V., Pahmeier, Felix, Zhu, Chi, Ruan, Richard, Blanc, Sophie F., Patel, Trishna S., Worthington, Caroline M., Glasner, Dustin R., Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas T. N., Wong, Marcus P., Warnes, Colin M., Sandoval, Daniel R., Clausen, Thomas Mandel, Santos, Yale A., Fox, Douglas M., Ortega, Victoria, Näär, Anders M., Baric, Ralph S., Stanley, Sarah A., Aguilar, Hector C., Esko, Jeffrey D., Chiu, Charles Y., Pak, John E., Beatty, P. Robert, Harris, Eva

“…Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an…”
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Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library by Sugiura, Nobuo, Clausen, Thomas Mandel, Shioiri, Tatsumasa, Gustavsson, Tobias, Watanabe, Hideto, Salanti, Ali

“…Placental malaria, a serious infection caused by the parasite Plasmodium falciparum , is characterized by the selective accumulation of infected erythrocytes…”
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Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate by Vidal-Calvo, Elena Ethel, Martin-Salazar, Anne, Choudhary, Swati, Dagil, Robert, Raghavan, Sai Sundar Rajan, Duvnjak, Lara, Nordmaj, Mie Anemone, Clausen, Thomas Mandel, Skafte, Ann, Oberkofler, Jan, Wang, Kaituo, Agerbæk, Mette Ø, Løppke, Caroline, Jørgensen, Amalie Mundt, Ropac, Daria, Mujollari, Joana, Willis, Shona, Garcias López, Agnès, Miller, Rebecca Louise, Karlsson, Richard Torbjörn Gustav, Goerdeler, Felix, Chen, Yen-Hsi, Colaço, Ana R., Wang, Yong, Lavstsen, Thomas, Martowicz, Agnieszka, Nelepcu, Irina, Marzban, Mona, Oo, Htoo Zarni, Ørum-Madsen, Maj Sofie, Wang, Yuzhuo, Nielsen, Morten A., Clausen, Henrik, Wierer, Michael, Wolf, Dominik, Gögenur, Ismail, Theander, Thor G., Al-Nakouzi, Nader, Gustavsson, Tobias, Daugaard, Mads, Salanti, Ali

“…Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One…”
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Post-acute sequelae of COVID infection and cerebral venous outflow disorders: Overlapping symptoms and mechanisms? by Clausen, Thomas Mandel, Fargen, Kyle M, Primiani, Christopher T, Sattur, Mithun, Amans, Matthew R, Hui, Ferdinand K

“…Neurological long Covid (NLC) is a major post-acute sequela of SARS-CoV-2 infection, affecting up to 10% of infected patients. The clinical presentation of…”
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An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer by Toledo, Alejandro Gómez, Pihl, Jessica, Spliid, Charlotte B, Persson, Andrea, Nilsson, Jonas, Pereira, Marina Ayres, Gustavsson, Tobias, Choudhary, Swati, Zarni Oo, Htoo, Black, Peter C, Daugaard, Mads, Esko, Jeffrey D, Larson, Göran, Salanti, Ali, Clausen, Thomas Mandel

“…Abstract Chondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein, expressed at the surface of infected erythrocytes during…”
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