Search Results - "Mande, Shekhar C"

Using structural knowledge in the protein data bank to inform the search for potential host-microbe protein interactions in sequence space: application to Mycobacterium tuberculosis by Mahajan, Gaurang, Mande, Shekhar C

“…A comprehensive map of the human-M. tuberculosis (MTB) protein interactome would help fill the gaps in our understanding of the disease, and computational…”
Get full text

Multiple chaperonins in bacteria—novel functions and non-canonical behaviors by Kumar, C. M. Santosh, Mande, Shekhar C., Mahajan, Gaurang

“…Chaperonins are a class of molecular chaperones that assemble into a large double ring architecture with each ring constituting seven to nine subunits and…”
Get full text

Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses by Rizvi, Arshad, Shankar, Arvind, Chatterjee, Ankita, More, Tushar H., Bose, Tungadri, Dutta, Anirban, Balakrishnan, Kannan, Madugulla, Lavanya, Rapole, Srikanth, Mande, Sharmila S., Banerjee, Sharmistha, Mande, Shekhar C.

“…Metabolic adaptation of Mycobacterium tuberculosis ( M. tuberculosis ) to microbicidal intracellular environment of host macrophages is fundamental to its…”
Get full text

From System-Wide Differential Gene Expression to Perturbed Regulatory Factors: A Combinatorial Approach by Mahajan, Gaurang, Mande, Shekhar C

“…High-throughput experiments such as microarrays and deep sequencing provide large scale information on the pattern of gene expression, which undergoes…”
Get full text

Structural aspects of lesional and non-lesional skin microbiota reveal key community changes in leprosy patients from India by Bayal, Nitin, Nagpal, Sunil, Haque, Mohammed Monzoorul, Patole, Milind S., Shouche, Yogesh, Mande, Shekhar C., Mande, Sharmila S.

“…Although skin is the primary affected organ in Leprosy, the role of the skin microbiome in its pathogenesis is not well understood. Recent reports have shown…”
Get full text

The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling by Sugandhi, Sapna, Rajmane, Vyankatesh, Taunk, Khushman, Jadhav, Sushama, Nema, Vijay, Rapole, Srikanth, Mande, Shekhar C.

“…Mycobacterium tuberculosis encounters diverse microenvironments, including oxidative assault (ROS and RNS), when it attempts to establish itself within its…”
Get full text

Exploiting 3D structural templates for detection of metal-binding sites in protein structures by Goyal, Kshama, Mande, Shekhar C.

“…High throughput structural genomics efforts have been making the structures of proteins available even before their function has been fully characterized…”
Get full text

A Glimpse Into the Structure and Function of Atypical Type I Chaperonins by Ansari, Mohammed Y, Mande, Shekhar C

“…Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type…”
Get full text

novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL by Basu, Debashree, Khare, Garima, Singh, Shashi, Tyagi, Anil, Khosla, Sanjeev, Mande, Shekhar C

“…The Mycobacterium tuberculosis genome sequence reveals remarkable absence of many nucleoid-associated proteins (NAPs), such as HNS, Hfq or DPS. In order to…”
Get full text

CoRNeA: A Pipeline to Decrypt the Inter-Protein Interfaces from Amino Acid Sequence Information by Chopra, Kriti, Burdak, Bhawna, Sharma, Kaushal, Kembhavi, Ajit, Mande, Shekhar C, Chauhan, Radha

“…Decrypting the interface residues of the protein complexes provides insight into the functions of the proteins and, hence, the overall cellular machinery…”
Get full text

Functional Studies of Multiple Thioredoxins from Mycobacterium tuberculosis by AKIF, Mohd, KHARE, Garima, TYAGI, Anil K, MANDE, Shekhar C, SARDESAI, Abhijit A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling by Hegde, Shubhada R, Rajasingh, Hannah, Das, Chandrani, Mande, Sharmila S, Mande, Shekhar C

“…About 90% of the people infected with Mycobacterium tuberculosis carry latent bacteria that are believed to get activated upon immune suppression. One of the…”
Get full text

16S rDNA based skin microbiome data of healthy individuals and leprosy patients from India by Bayal, Nitin, Nagpal, Sunil, Haque, Mohammed Monzoorul, Patole, Milind S., Valluri, Vijayalakshmi, Suryavanshi, Rohini, Mande, Sharmila S., Mande, Shekhar C.

“…Leprosy is an infectious disease that has predilection in skin and peripheral nerves. Skin has its own microbiome, however it is not extensively studied in…”
Get full text

Multiple gene duplication and rapid evolution in the groEL gene: functional implications by Goyal, Kshama, Qamra, Rohini, Mande, Shekhar C

“…The chaperonins, GroEL and GroES, are present ubiquitously and provide a paradigm in the understanding of assisted protein folding. Due to its essentiality of…”
Get full text

Chaperonin Abundance Enhances Bacterial Fitness by Kumar, C. M. Santosh, Chugh, Kritika, Dutta, Anirban, Mahamkali, Vishnuvardhan, Bose, Tungadri, Mande, Sharmila S., Mande, Shekhar C., Lund, Peter A.

“…The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here,…”
Get full text

Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis by Arora, Gunjan, Sajid, Andaleeb, Virmani, Richa, Singhal, Anshika, Kumar, C. M. Santosh, Dhasmana, Neha, Khanna, Tanya, Maji, Abhijit, Misra, Richa, Molle, Virginie, Becher, Dörte, Gerth, Ulf, Mande, Shekhar C., Singh, Yogendra

“…PrkC is a conserved Ser/Thr protein kinase encoded in Bacillus anthracis genome. PrkC is shown to be important for B. anthracis pathogenesis, but little is…”
Get full text

Crystal Structure of the 65-Kilodalton Heat Shock Protein, Chaperonin 60.2, of Mycobacterium tuberculosis by QAMRA, Rohini, MANDE, Shekhar C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization by SANTOSH KUMAR, C. M, KHARE, Garima, SRIKANTH, C. V, TYAGI, Anil K, SARDESAI, Abhijit A, MANDE, Shekhar C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mycobacterium tuberculosis GroEL Homologues Unusually Exist as Lower Oligomers and Retain the Ability to Suppress Aggregation of Substrate Proteins by Qamra, Rohini, Srinivas, Volety, Mande, Shekhar C.

“…Chaperonin-60s are large double ring oligomeric proteins with a central cavity where unfolded polypeptides undergo productive folding. In conjunction with…”
Get full text

Dynamic changes in protein functional linkage networks revealed by integration with gene expression data by Hegde, Shubhada R, Manimaran, Palanisamy, Mande, Shekhar C

“…Response of cells to changing environmental conditions is governed by the dynamics of intricate biomolecular interactions. It may be reasonable to assume,…”
Get full text