Search Results - "Mancini, Manuela"

Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy by Soverini, Simona, Mancini, Manuela, Bavaro, Luana, Cavo, Michele, Martinelli, Giovanni

“…Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is…”
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Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort? by Soverini, Simona, De Santis, Sara, Monaldi, Cecilia, Bruno, Samantha, Mancini, Manuela

“…Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in a multipotent hematopoietic stem cell upon the acquisition of the…”
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Study of Variability of Waste Wood Samples Collected in a Panel Board Industry by Mancini, Manuela, Rinnan, Åsmund

“…Waste wood is becoming an appealing alternative material to virgin wood, and the main drivers are the increased demand for waste wood by the panel industry,…”
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The Role of Hypoxic Bone Marrow Microenvironment in Acute Myeloid Leukemia and Future Therapeutic Opportunities by Bruno, Samantha, Mancini, Manuela, De Santis, Sara, Monaldi, Cecilia, Cavo, Michele, Soverini, Simona

“…Acute myeloid leukemia (AML) is a hematologic malignancy caused by a wide range of alterations responsible for a high grade of heterogeneity among patients…”
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Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy by Martelli, Margherita, Monaldi, Cecilia, De Santis, Sara, Bruno, Samantha, Mancini, Manuela, Cavo, Michele, Soverini, Simona

“…In recent years, molecular characterization and management of patients with systemic mastocytosis (SM) have greatly benefited from the application of advanced…”
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Mutations in the BCR-ABL1 Kinase Domain and Elsewhere in Chronic Myeloid Leukemia by Soverini, Simona, de Benedittis, Caterina, Mancini, Manuela, Martinelli, Giovanni

“…Abstract Chronic myeloid leukemia (CML) has been the first human malignancy to be associated, more than 50 years ago, with a consistent chromosomal…”
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Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets by Bruno, Samantha, Borsi, Enrica, Patuelli, Agnese, Bandini, Lorenza, Mancini, Manuela, Forte, Dorian, Nanni, Jacopo, Barone, Martina, Grassi, Alessandra, Cristiano, Gianluca, Venturi, Claudia, Robustelli, Valentina, Atzeni, Giulia, Mosca, Cristina, De Santis, Sara, Monaldi, Cecilia, Poletti, Andrea, Terragna, Carolina, Curti, Antonio, Cavo, Michele, Soverini, Simona, Ottaviani, Emanuela

“…Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the gene…”
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New Symptoms in Castanea sativa Stands in Italy: Chestnut Mosaic Virus and Nutrient Deficiency by Sergio Murolo, Daniela Bertoldi, Federico Pedrazzoli, Manuela Mancini, Gianfranco Romanazzi, Giorgio Maresi

“…The European chestnut characterizes both the landscape and economy of mountainous Italian areas. In recent years, new canopy disorders have been reported:…”
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Application of the Non-Destructive NIR Technique for the Evaluation of Strawberry Fruits Quality Parameters by Mancini, Manuela, Mazzoni, Luca, Gagliardi, Francesco, Balducci, Francesca, Duca, Daniele, Toscano, Giuseppe, Mezzetti, Bruno, Capocasa, Franco

“…The determination of strawberry fruit quality through the traditional destructive lab techniques has some limitations related to the amplitude of the samples,…”
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Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis by Corradi, Valentina, Mancini, Manuela, Manetti, Fabrizio, Petta, Sara, Santucci, Maria Alessandra, Botta, Maurizio

“…The first non-peptidic small molecule able to bind 14-3-3 and to disrupt the c-Abl/14-3-3 complex was discovered by an in silico structure-based drug design…”
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Polo-like kinase-1, Aurora kinase A and WEE1 kinase are promising druggable targets in CML cells displaying BCR::ABL1-independent resistance to tyrosine kinase inhibitors by Mancini, Manuela, De Santis, Sara, Monaldi, Cecilia, Castagnetti, Fausto, Lonetti, Annalisa, Bruno, Samantha, Dan, Elisa, Sinigaglia, Barbara, Rosti, Gianantonio, Cavo, Michele, Gugliotta, Gabriele, Soverini, Simona

“…In chronic myeloid leukemia (CML), Aurora kinase A and Polo like kinase 1 (PLK1), two serine-threonine kinases involved in the maintenance of genomic stability…”
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SYSTEMIC MASTOCYTOSIS: MOLECULAR LANDSCAPE AND IMPLICATIONS FOR TREATMENT by Monaldi, Cecilia, Sara De Santis, Manuela Mancini, Samantha Bruno, Michele Cavo, Simona Soverini

“…Over the past decade we have witnessed major advances in the molecular characterization of systemic mastocytosis (SM). This has provided important information…”
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Next-generation sequencing for sensitive detection of BCR-ABL1 mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients by Soverini, Simona, De Benedittis, Caterina, Polakova, Katerina Machova, Linhartova, Jana, Castagnetti, Fausto, Gugliotta, Gabriele, Papayannidis, Cristina, Mancini, Manuela, Klamova, Hana, Salvucci, Marzia, Crugnola, Monica, Iurlo, Alessandra, Albano, Francesco, Russo, Domenico, Rosti, Gianantonio, Cavo, Michele, Baccarani, Michele, Martinelli, Giovanni

“…In chronic myeloid leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) patients who fail imatinib treatment, BCR-ABL1 mutation…”
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Application of Near Infrared Spectroscopy for the Rapid Assessment of Nutritional Quality of Different Strawberry Cultivars by Mancini, Manuela, Mazzoni, Luca, Leoni, Elena, Tonanni, Virginia, Gagliardi, Francesco, Qaderi, Rohullah, Capocasa, Franco, Toscano, Giuseppe, Mezzetti, Bruno

“…Strawberry is the most cultivated berry fruit globally and it is really appreciated by consumers because of its characteristics, mainly bioactive compounds…”
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FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage by Mancini, Manuela, Castagnetti, Fausto, Soverini, Simona, Leo, Elisa, De Benedittis, Caterina, Gugliotta, Gabriele, Rosti, Gianantonio, Bavaro, Luana, De Santis, Sara, Monaldi, Cecilia, Martelli, Margherita, Santucci, Maria Alessandra, Cavo, Michele, Martinelli, Giovanni

“…ABSTRACT FOXM1 transcription factor is a central component of tumor initiation, growth, and progression due to its multiple effects on cell cycle, DNA repair,…”
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A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib by Mancini, Manuela, Corradi, Valentina, Petta, Sara, Barbieri, Enza, Manetti, Fabrizio, Botta, Maurizio, Santucci, Maria Alessandra

“…Resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitor imatinib mesylate (IM) is most often due to point mutations in the Bcr-Abl fusion…”
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Prognosis in Chronic Myeloid Leukemia: Baseline Factors, Dynamic Risk Assessment and Novel Insights by Iezza, Miriam, Cortesi, Sofia, Ottaviani, Emanuela, Mancini, Manuela, Venturi, Claudia, Monaldi, Cecilia, De Santis, Sara, Testoni, Nicoletta, Soverini, Simona, Rosti, Gianantonio, Cavo, Michele, Castagnetti, Fausto

“…The introduction of tyrosine kinase inhibitors (TKIs) has changed the treatment paradigm of chronic myeloid leukemia (CML), leading to a dramatic improvement…”
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Prediction of Soluble Solids Content by Means of NIR Spectroscopy and Relation with Botrytis cinerea Tolerance in Strawberry Cultivars by Mancini, Manuela, Mazzoni, Luca, Qaderi, Rohullah, Leoni, Elena, Tonanni, Virginia, Gagliardi, Francesco, Capocasa, Franco, Toscano, Giuseppe, Mezzetti, Bruno

“…Strawberry fruits are particularly appreciated by consumers for their sweet taste related to their soluble solids content (SSC). However, strawberries are…”
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Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia by Bruno, Samantha, Bandini, Lorenza, Patuelli, Agnese, Robustelli, Valentina, Venturi, Claudia, Mancini, Manuela, Forte, Dorian, De Santis, Sara, Monaldi, Cecilia, Grassi, Alessandra, Chiurumbolo, Gabriella, Paolini, Stefania, Cristiano, Gianluca, Papayannidis, Cristina, Sartor, Chiara, Nanni, Jacopo, Ottaviani, Emanuela, Curti, Antonio, Cavo, Michele, Soverini, Simona

“…FMS-like tyrosine kinase 3 (FLT3) is among the most common driver genes recurrently mutated in acute myeloid leukemia (AML), accounting for approximately 30%…”
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Near infrared spectroscopy for assessing mechanical properties of Castanea sativa wood samples by Mancini, Manuela, Leoni, Elena, Nocetti, Michela, Urbinati, Carlo, Duca, Daniele, Brunetti, Michele, Toscano, Giuseppe

“…Near infrared spectroscopy (NIR) is a technique widely used for the prediction of different chemical-physical features of wood. In this study, the technique…”
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