Search Results - "Mancini, Arturo D"

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? by Mancini, Arturo D, Poitout, Vincent

“…Highlights • Activation of GPR40 by fatty acids potentiates glucose-induced insulin secretion. • GPR40 is not implicated in the toxic effects of chronic fatty…”
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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets by Vivot, Kevin, Moullé, Valentine S, Zarrouki, Bader, Tremblay, Caroline, Mancini, Arturo D, Maachi, Hasna, Ghislain, Julien, Poitout, Vincent

“…Abstract Objective G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been…”
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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1 by Mancini, Arturo D., Bertrand, Gyslaine, Vivot, Kevin, Carpentier, Éric, Tremblay, Caroline, Ghislain, Julien, Bouvier, Michel, Poitout, Vincent

“…FFAR1/GPR40 is a seven-transmembrane domain receptor (7TMR) expressed in pancreatic β cells and activated by FFAs. Pharmacological activation of GPR40 is a…”
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Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes by Mancini, Arturo D, Poitout, Vincent

“…Glucose homeostasis requires a tight regulation of insulin secretion from pancreatic β-cells. Insulin release is chiefly stimulated by glucose, but also…”
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TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40 by Mancini, Arturo D, Carpentier, Éric, Bouvier, Michel, Poitout, Vincent

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GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit by Mancini, A. D., Poitout, V.

“…The free fatty acid receptor GPR40 has been proposed as a potential target for type 2 diabetes (T2D) pharmacotherapy. This idea has been validated in both…”
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Abstract 6304: Decrypting EGFR signaling with BRET biosensors: A novel approach to study RTK mutations and the effects of inhibitors by Gross, Florence, Dugast, Guilhem, Mancini, Arturo D., Schann, Stephan, Leroy, Xavier

“…Abstract Receptor tyrosine kinases (RTKs) comprise nodes at the center of complex signaling networks regulating various aspects of cell growth, differentiation…”
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