Search Results - "Mancias, Joseph D"

The Role of NCOA4-Mediated Ferritinophagy in Health and Disease by Santana-Codina, Naiara, Mancias, Joseph D

“…Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin ("ferritinophagy"), the cytosolic…”
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Mechanisms of Selective Autophagy in Normal Physiology and Cancer by Mancias, Joseph D., Kimmelman, Alec C.

“…Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal turnover of a wide variety of substrates including proteins,…”
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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy by Mancias, Joseph D., Wang, Xiaoxu, Gygi, Steven P., Harper, J. Wade, Kimmelman, Alec C.

“…Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4…”
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KRAS: feeding pancreatic cancer proliferation by Bryant, Kirsten L., Mancias, Joseph D., Kimmelman, Alec C., Der, Channing J.

“…•KRAS is the most frequently mutated gene in PDAC and drives cancer development and growth.•Oncogenic KRAS alters cellular glucose uptake, glycolytic flux, and…”
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NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration by Quiles Del Rey, Maria, Mancias, Joseph D

“…NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing…”
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Plasticity in binding confers selectivity in ligand-induced protein degradation by Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

“…Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new…”
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Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries by Kuljanin, Miljan, Mitchell, Dylan C., Schweppe, Devin K., Gikandi, Ajami S., Nusinow, David P., Bulloch, Nathan J., Vinogradova, Ekaterina V., Wilson, David L., Kool, Eric T., Mancias, Joseph D., Cravatt, Benjamin F., Gygi, Steven P.

“…Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the…”
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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer by Banh, Robert S., Biancur, Douglas E., Yamamoto, Keisuke, Sohn, Albert S.W., Walters, Beth, Kuljanin, Miljan, Gikandi, Ajami, Wang, Huamin, Mancias, Joseph D., Schneider, Robert J., Pacold, Michael E., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironment. Although neurons can release…”
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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules by Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.

“…Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic…”
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism by Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Quiles Del Rey, Maria, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these…”
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Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11 by Mukhopadhyay, Subhadip, Biancur, Douglas E., Parker, Seth J., Yamamoto, Keisuke, Banh, Robert S., Paulo, Joao A., Mancias, Joseph D., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer and is highly refractory to current therapies. We had previously shown that…”
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Structural basis of cargo membrane protein discrimination by the human COPII coat machinery by Mancias, Joseph D, Goldberg, Jonathan

“…Genomic analysis shows that the increased complexity of trafficking pathways in mammalian cells involves an expansion of the number of SNARE, Rab and COP…”
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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis by Mancias, Joseph D, Pontano Vaites, Laura, Nissim, Sahar, Biancur, Douglas E, Kim, Andrew J, Wang, Xiaoxu, Liu, Yu, Goessling, Wolfram, Kimmelman, Alec C, Harper, J Wade

“…NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However,…”
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The Role of Autophagy in Cancer by Santana-Codina, Naiara, Mancias, Joseph D, Kimmelman, Alec C

“…Autophagy is a highly conserved and regulated process that targets proteins and damaged organelles for lysosomal degradation to maintain cell metabolism,…”
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Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer by Hollinshead, Kate E.R., Parker, Seth J., Eapen, Vinay V., Encarnacion-Rosado, Joel, Sohn, Albert, Oncu, Tugba, Cammer, Michael, Mancias, Joseph D., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low…”
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Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review by de Geus, Susanna W. L., Eskander, Mariam F., Kasumova, Gyulnara G., Ng, Sing Chau, Kent, Tara S., Mancias, Joseph D., Callery, Mark P., Mahadevan, Anand, Tseng, Jennifer F.

“…BACKGROUND The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body…”
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Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate by Jayaraman, Divya, Kodani, Andrew, Gonzalez, Dilenny M., Mancias, Joseph D., Mochida, Ganeshwaran H., Vagnoni, Cristiana, Johnson, Jeffrey, Krogan, Nevan, Harper, J. Wade, Reiter, Jeremy F., Yu, Timothy W., Bae, Byoung-il, Walsh, Christopher A.

“…Mutations in several genes encoding centrosomal proteins dramatically decrease the size of the human brain. We show that Aspm (abnormal spindle-like,…”
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NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins by Santana-Codina, Naiara, Del Rey, Maria Quiles, Kapner, Kevin S, Zhang, Huan, Gikandi, Ajami, Malcolm, Callum, Poupault, Clara, Kuljanin, Miljan, John, Kristen M, Biancur, Douglas E, Chen, Brandon, Das, Nupur K, Lowder, Kristen E, Hennessey, Connor J, Huang, Wesley, Yang, Annan, Shah, Yatrik M, Nowak, Jonathan A, Aguirre, Andrew J, Mancias, Joseph D

“…Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression…”
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Structure and Organization of Coat Proteins in the COPII Cage by Fath, Stephan, Mancias, Joseph D., Bi, Xiping, Goldberg, Jonathan

“…COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo…”
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A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer by Parikh, Parag Jitendra, Lee, Percy, Low, Daniel A., Kim, Joshua, Mittauer, Kathryn E., Bassetti, Michael F., Glide-Hurst, Carri K., Raldow, Ann C., Yang, Yingli, Portelance, Lorraine, Padgett, Kyle R., Zaki, Bassem, Zhang, Rongxiao, Kim, Hyun, Henke, Lauren E., Price, Alex T., Mancias, Joseph D., Williams, Christopher L., Ng, John, Pennell, Ryan, Pfeffer, M. Raphael, Levin, Daphne, Mueller, Adam C., Mooney, Karen E., Kelly, Patrick, Shah, Amish P., Boldrini, Luca, Placidi, Lorenzo, Fuss, Martin, Chuong, Michael D.

“…Magnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We…”
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