Search Results - "Manautou, Jose E"

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury by Laddha, Ankit P, Wu, Hangyu, Manautou, Jose E

“…Acetaminophen (APAP) is the most used non-prescription drug throughout the world. At therapeutic doses, APAP has potent analgesic and antipyretic effects. The…”
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Molecular mechanisms underlying chemical liver injury by Gu, Xinsheng, Manautou, Jose E

“…The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in the metabolism of xenobiotics render this organ particularly…”
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Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1 α Antisense RNA 1 and Hepatocyte Nuclear Factor 4 α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells by Chen, Liming, Wang, Pei, Manautou, José E, Zhong, Xiao-Bo

“…Acetaminophen (APAP) is a commonly used over-the-counter drug for its analgesic and antipyretic effects. However, APAP overdose leads to severe APAP-induced…”
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Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease by Aleksunes, Lauren M., Manautou, José E.

“…Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper family and is activated in response to electrophiles and reactive…”
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Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics by Ghanem, Carolina I, Manautou, Jose E

“…Liver transporters play an important role in the pharmacokinetics and disposition of pharmaceuticals, environmental contaminants, and endogenous compounds…”
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Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice? by Rohrer, Philip R, Rudraiah, Swetha, Goedken, Michael J, Manautou, José E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively regulates the expression and activity of cytoprotective genes…”
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Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice by Ghanem, Carolina I., Rudraiah, Swetha, Bataille, Amy M., Vigo, María B., Goedken, Michael J., Manautou, José E.

“…Changes in expression of liver ABC transporters have been described during acute APAP intoxication. However, the effect of APAP on brain ABC transporters is…”
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Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites by Scialis, Renato J, Aleksunes, Lauren M, Csanaky, Iván L, Klaassen, Curtis D, Manautou, José E

“…In the present work, in vivo transporter knockout (KO) mouse models were used to characterize the disposition of diclofenac (DCF) and its primary metabolites…”
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Development of precision medicine approaches based on inter-individual variability of BCRP/ ABCG2 by Chen, Liming, Manautou, Jose E, Rasmussen, Theodore P, Zhong, Xiao-Bo

“…Precision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and…”
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Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity by Aleksunes, Lauren M, Goedken, Michael J, Rockwell, Cheryl E, Thomale, Juergen, Manautou, Jose E, Klaassen, Curtis D

“…The use of the chemotherapeutic drug cisplatin is limited in part by nephrotoxicity. Cisplatin causes renal DNA adducts and oxidative stress in rodents. The…”
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Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease by Hardwick, Rhiannon N, Ferreira, Daniel W, More, Vijay R, Lake, April D, Lu, Zhenqiang, Manautou, Jose E, Slitt, Angela L, Cherrington, Nathan J

“…The UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) represent major phase II drug-metabolizing enzymes that are also responsible for…”
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Regulation of hepatic ABCC transporters by xenobiotics and in disease states by Gu, Xinsheng, Manautou, Jose E.

“…The subfamily of ABCC transporters consists of 13 members in mammals, including the multidrug resistance-associated proteins (MRPs), sulfonylurea receptors…”
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Emerging Therapeutic Modalities against COVID-19 by Malik, Shipra, Gupta, Anisha, Zhong, Xiaobo, Rasmussen, Theodore P., Manautou, Jose E., Bahal, Raman

“…The novel SARS-CoV-2 virus has quickly spread worldwide, bringing the whole world as well as the economy to a standstill. As the world is struggling to…”
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Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway by Maher, Jonathan M., Dieter, Matthew Z., Aleksunes, Lauren M., Slitt, Angela L., Guo, Grace, Tanaka, Yuji, Scheffer, George L., Chan, Jefferson Y., Manautou, Jose E., Chen, Ying, Dalton, Timothy P., Yamamoto, Masayuki, Klaassen, Curtis D.

“…Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2…”
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Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions by Ferreira, Daniel W, Naquet, Philippe, Manautou, Jose E

“…In liver, cysteamine in all probability represents a "low-capacity, high-affinity" scavenger of ROS. The available body of evidence suggests that reduced…”
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Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis by Canet, Mark J, Merrell, Matthew D, Hardwick, Rhiannon N, Bataille, Amy M, Campion, Sarah N, Ferreira, Daniel W, Xanthakos, Stavra A, Manautou, Jose E, A-Kader, H Hesham, Erickson, Robert P, Cherrington, Nathan J

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, representing a spectrum of liver pathologies that include simple hepatic…”
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Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice by Park, Hea Jin, DiNatale, Dana A, Chung, Min-Yu, Park, Young-Ki, Lee, Ji-Young, Koo, Sung I, O'Connor, Meeghan, Manautou, Jose E, Bruno, Richard S

“…Excess hepatic lipid accumulation and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD). Thus, we hypothesized that the hypolipidemic and…”
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Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity by Cheng, Qiuqiong, Aleksunes, Lauren M, Manautou, José E, Cherrington, Nathan J, Scheffer, George L, Yamasaki, Hideki, Slitt, Angela L

“…Obesity and type II diabetes pose a serious human health risk. Obese or diabetic patients usually take prescription drugs that require hepatic and renal…”
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Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells by Rudraiah, Swetha, Gu, Xinsheng, Hines, Ronald N., Manautou, José E.

“…The flavin-containing monooxygenases (FMOs) are important for the oxidation of a variety of endogenous compounds and xenobiotics. The hepatic expression of…”
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Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes by Chung, Min-Yu, Park, Hea Jin, Manautou, Jose E, Koo, Sung I, Bruno, Richard S

“…Oxidative and nitrative stress responses resulting from inflammation exacerbate liver injury associated with nonalcoholic steatohepatitis (NASH) by inducing…”
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