Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis

IntroductionScabies is recognised as a neglected tropical disease, disproportionately affecting the most vulnerable populations around the world. Impetigo often occurs secondarily to scabies. Several studies have explored mass drug administration (MDA) programmes, with some showing positive outcomes...

Full description

Saved in:

Bibliographic Details
Published in:	BMJ paediatrics open Vol. 5; no. 1; p. e001132
Main Authors:	Ghosh, Pousali, Tesfaye, Wubshet, Manandhar, Avilasha, Calma, Thomas, Bushell, Mary, Oguoma, Victor M, Kosari, Sam, McMillan, Faye, Peterson, Greg, Thomas, Jackson
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 29-06-2021 BMJ Publishing Group
Subjects:	Antibiotics Australia Cardiovascular disease Clinical trials Drug therapy Humans Impetigo Impetigo - drug therapy Infections Integrated approach Intervention Keywords Mass Drug Administration Meta-analysis Meta-Analysis as Topic Parasitic diseases Pediatrics Prospective Studies Protocol Rheumatic fever Scabies - drug therapy Skin diseases Systematic review Systematic Reviews as Topic Tropical diseases Australia impetigo norwegian scabies permethrin skin sores crusted scabies scabies azithromycin MDA ivermectin school sores
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	IntroductionScabies is recognised as a neglected tropical disease, disproportionately affecting the most vulnerable populations around the world. Impetigo often occurs secondarily to scabies. Several studies have explored mass drug administration (MDA) programmes, with some showing positive outcomes—but a systematic evaluation of such studies is yet to be reported. The main aim of this systematic review is to generate comprehensive evidence on the effect and feasibility of MDA programmes in reducing the burden of scabies and impetigo.Methods and analysisA systematic review and meta-analysis will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Electronic databases to be searched will include CINAHL EBSCOhost, Medline Ovid, ProQuest, Science Direct, PubMed and SCOPUS. In addition, grey literature will be explored via the Australian Institute of Health and Welfare, Australian Indigenous HealthInfoNet, Informit, OaIster database and WHO. No language restrictions will be applied. All treatment studies following an MDA protocol, including randomised/quasi-controlled trials, and prospective before–after interventional studies, will be considered. The main outcome is the change in prevalence of scabies and impetigo The Cochrane collaboration risk of bias assessment tool will be used for assessing the methodological quality of studies. A random-effect restricted maximum likelihood meta-analysis will be performed to generate pooled effect (OR) using STATA V.16. Appropriate statistical tests will be carried out to quantify heterogeneity between studies and publication bias.Ethics and disseminationEthical approval is not required since data will be extracted from published works. The findings will be communicated to the scientific community through a peer-reviewed journal publication. This systematic review will present an evidence on the effect of MDA interventions on scabies and impetigo, which is instrumental to obtain a clear understanding of the treatments widely used in these programmes.PROSPERO registration numberCRD42020169544,
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2399-9772 2399-9772
DOI:	10.1136/bmjpo-2021-001132