Search Results - "Manabe, Noriyoshi"

3D Structural Insights into β-Glucans and Their Binding Proteins by Manabe, Noriyoshi, Yamaguchi, Yoshiki

“…β(1,3)-glucans are a component of fungal and plant cell walls. The β-glucan of pathogens is recognized as a non-self-component in the host defense system. Long…”
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3D Structures of IgA, IgM, and Components by Pan, Shunli, Manabe, Noriyoshi, Yamaguchi, Yoshiki

“…Immunoglobulin G (IgG) is currently the most studied immunoglobin class and is frequently used in antibody therapeutics in which its beneficial effector…”
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Comparative Conformational Analysis of Acyclic Sugar Alcohols Ribitol, Xylitol and d-Arabitol by Solution NMR and Molecular Dynamics Simulations by Ohno, Shiho, Manabe, Noriyoshi, Uzawa, Jun, Yamaguchi, Yoshiki

“…Ribitol (C H O ) is an acyclic sugar alcohol that was recently identified in -mannose glycan on mammalian α-dystroglycan. The conformation and dynamics of…”
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Ribitol in Solution Is an Equilibrium of Asymmetric Conformations by Ohno, Shiho, Manabe, Noriyoshi, Yamaguchi, Takumi, Uzawa, Jun, Yamaguchi, Yoshiki

“…Ribitol (C5H12O5), an acyclic sugar alcohol, is present on mammalian α-dystroglycan as a component of O-mannose glycan. In this study, we examine the…”
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Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism by Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi

“…Aspartic acid (Asp) residues in proteins and peptides are prone to the non-enzymatic reactions that give biologically uncommon l-β-Asp, d-Asp, and d-β-Asp…”
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A Data Set of Ion Mobility Collision Cross Sections and Liquid Chromatography Retention Times from 71 Pyridylaminated N‑Linked Oligosaccharides by Manabe, Noriyoshi, Ohno, Shiho, Matsumoto, Kana, Kawase, Taiji, Hirose, Kenji, Masuda, Katsuyoshi, Yamaguchi, Yoshiki

“…Determination of the glycan structure is an essential step in understanding structure–function relationships of glycans and glycoconjugates including…”
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Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate Ion by Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi

“…In proteins and peptides, d-aspartic acid (d-Asp) and d-β-Asp residues can be spontaneously formed via racemization of the succinimide intermediate formed from…”
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Phosphate-Catalyzed Succinimide Formation from an NGR-Containing Cyclic Peptide: A Novel Mechanism for Deammoniation of the Tetrahedral Intermediate by Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi

“…Spontaneous deamidation in the Asn-Gly-Arg (NGR) motif that yields an Asp-Gly-Arg ( DGR) sequence has recently attracted considerable attention because of the…”
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Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain by Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi

“…The Asn-Gly-Arg (NGR) motif and its deamidation product Asp-Gly-Arg ( DGR) have recently attracted considerable attention as tumor-targeting ligands. Because…”
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3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors by Manabe, Noriyoshi, Yamaguchi, Yoshiki

“…Humans and other mammals resist exogenous pathogens by recognizing them as non-self. How do they do this? The answer lies in the recognition by mammalian…”
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Roles of intramolecular and intermolecular hydrogen bonding in a three-water-assisted mechanism of succinimide formation from aspartic acid residues by Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi

“…Aspartic acid (Asp) residues in peptides and proteins are prone to isomerization to the β-form and racemization via a five-membered succinimide intermediate…”
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Molecular Dynamics Simulations to Investigate the Influences of Amino Acid Mutations on Protein Three-Dimensional Structures of Cytochrome P450 2D6.1, 2, 10, 14A, 51, and 62 by Fukuyoshi, Shuichi, Kometani, Masaharu, Watanabe, Yurie, Hiratsuka, Masahiro, Yamaotsu, Noriyuki, Hirono, Shuichi, Manabe, Noriyoshi, Takahashi, Ohgi, Oda, Akifumi

“…Many natural mutants of the drug metabolizing enzyme cytochrome P450 (CYP) 2D6 have been reported. Because the enzymatic activities of many mutants are…”
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Complementary Design for Pairing between Two Types of Nanoparticles Mediated by a Bispecific Antibody: Bottom-Up Formation of Porous Materials from Nanoparticles by Niide, Teppei, Manabe, Noriyoshi, Nakazawa, Hikaru, Akagi, Kazuto, Hattori, Takamitsu, Kumagai, Izumi, Umetsu, Mitsuo

“…Recent advances in biotechnology have enabled the generation of antibodies with high affinity for the surfaces of specific inorganic materials. Herein, we…”
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A Computational Study of the Mechanism of Succinimide Formation in the Asn-His Sequence: Intramolecular Catalysis by the His Side Chain by Takahashi, Ohgi, Manabe, Noriyoshi, Kirikoshi, Ryota

“…The rates of deamidation reactions of asparagine (Asn) residues which occur spontaneously and nonenzymatically in peptides and proteins via the succinimide…”
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O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations by Kokubu, Ryoka, Ohno, Shiho, Kuratani, Hirohide, Takahashi, Yuka, Manabe, Noriyoshi, Shimizu, Hiroki, Chiba, Yasunori, Denda-Nagai, Kaori, Tsuiji, Makoto, Irimura, Tatsuro, Yamaguchi, Yoshiki

“…Anti-mucin1 (MUC1) antibodies have been widely used for breast cancer diagnosis and treatment. This is based on the fact that MUC1 undergoes aberrant…”
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Acetic acid can catalyze succinimide formation from aspartic acid residues by a concerted bond reorganization mechanism: a computational study by Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi

“…Succinimide formation from aspartic acid (Asp) residues is a concern in the formulation of protein drugs. Based on density functional theory calculations using…”
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Chemical and Chemo-Enzymatic Syntheses of Glycans Containing Ribitol Phosphate Scaffolding of Matriglycan by Tamura, Jun-ichi, Tamura, Takahiro, Hoshino, Shunsuke, Imae, Rieko, Kato, Ryuichi, Yokono, Mizuki, Nagase, Mao, Ohno, Shiho, Manabe, Noriyoshi, Yamaguchi, Yoshiki, Manya, Hiroshi, Endo, Tamao

“…Ribitol phosphate modifications to the core M3 O-mannosyl glycan are important for the functional maturation of α-dystroglycan. Three sequentially extended…”
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Glycolic acid-catalyzed deamidation of asparagine residues in degrading PLGA matrices: a computational study by Manabe, Noriyoshi, Kirikoshi, Ryota, Takahashi, Ohgi

“…Poly(lactic-co-glycolic acid) (PLGA) is a strong candidate for being a drug carrier in drug delivery systems because of its biocompatibility and…”
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Racemization of Serine Residues Catalyzed by Dihydrogen Phosphate Ion: A Computational Study by Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe

“…Spontaneous, nonenzymatic reactions in proteins are known to have relevance to aging and age-related diseases, such as cataract and Alzheimer’s disease. Among…”
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Functional evaluation of novel variants of B4GALNT1 in a patient with hereditary spastic paraplegia and the general population by Inamori, Kei-Ichiro, Nakamura, Katsuya, Shishido, Fumi, Hsu, Jia-Chen, Nagafuku, Masakazu, Nitta, Takahiro, Ikeda, Junji, Yoshimura, Hidekane, Kodaira, Minori, Tsuchida, Naomi, Matsumoto, Naomichi, Uemura, Satoshi, Ohno, Shiho, Manabe, Noriyoshi, Yamaguchi, Yoshiki, Togayachi, Akira, Aoki-Kinoshita, Kiyoko F, Nishihara, Shoko, Furukawa, Jun-Ichi, Kaname, Tadashi, Nakamura, Masahiko, Shimohata, Takayoshi, Tadaka, Shu, Shirota, Matsuyuki, Kinoshita, Kengo, Nakamura, Yutaka, Ohno, Isao, Sekijima, Yoshiki, Inokuchi, Jin-Ichi

“…Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurological disorders that are characterized by progressive spasticity and weakness in the…”
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