Search Results - "Man, Y K Stella"

Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer by Stella Man, Y. K., Foster, Julie, Carapuça, Elisabete, Davies, James A., Parker, Alan L., Sosabowski, Jane, Halldén, Gunnel

“…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
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Hypoxia and its therapeutic possibilities in paediatric cancers by Bernauer, Carolina, Man, Y. K. Stella, Chisholm, Julia C., Lepicard, Elise Y., Robinson, Simon P., Shipley, Janet M.

“…In tumours, hypoxia—a condition in which the demand for oxygen is higher than its availability—is well known to be associated with reduced sensitivity to…”
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The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells by Man, Y K Stella, Davies, James A, Coughlan, Lynda, Pantelidou, Constantia, Blázquez-Moreno, Alfonso, Marshall, John F, Parker, Alan L, Halldén, Gunnel

“…Metastatic pancreatic ductal adenocarcinomas (PDAC) are incurable due to the rapid development of resistance to all current therapeutics. Oncolytic adenoviral…”
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Deafness-Associated Mutant Human Connexin 26 Improves the Epithelial Barrier In Vitro by Man, Y. K. Stella, Trolove, Caroline, Tattersall, Daniel, Thomas, Anna C, Papakonstantinopoulou, Annie, Patel, Drashnika, Scott, Claire, Chong, Jiehan, Jagger, Daniel J, O'Toole, Edel A, Navsaria, Harshad, Curtis, Michael A, Kelsell, David P

“…A large proportion of recessive nonsyndromic hearing loss is due to mutations in the GJB2 gene encoding connexin 26 (Cx26), a component of a gap junction…”
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Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy by Gonzalez-Pastor, Rebeca, Hernandez, Yulan, Gimeno, Marina, de Martino, Alba, Man, Y.K. Stella, Hallden, Gunnel, Quintanilla, Miguel, de la Fuente, Jesus M, Martin-Duque, Pilar

“…Adenoviral (Ad) vectors have proven to be important tools for gene and cell therapy, although some issues still need to be addressed, such as undesired…”
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FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas by Milton, Christopher I., Selfe, Joanna, Aladowicz, Ewa, Man, Stella Y. K., Bernauer, Carolina, Missiaglia, Edoardo, Walters, Zoë S., Gatz, Susanne A., Kelsey, Anna, Generali, Melanie, Box, Gary, Valenti, Melanie, Haven‐Brandon, Alexis, Galiwango, David, Hayes, Angela, Clarke, Matthew, Izquierdo, Elisa, Gonzalez De Castro, David, Raynaud, Florence I., Kirkin, Vladimir, Shipley, Janet M.

“…Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor…”
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Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide by Wythe, Sarah E, DiCara, Danielle, Taher, Taher E I, Finucane, Ciara M, Jones, Rita, Bombardieri, Michele, Man, Y K Stella, Nissim, Ahuva, Mather, Stephen J, Chernajovsky, Yuti, Pitzalis, Costantino

“…The synovial endothelium targeting peptide (SyETP) CKSTHDRLC has been identified previously and was shown to preferentially localise to synovial xenografts in…”
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Structural guided scaffold phage display libraries as a source of bio-therapeutics by Man, Y K Stella, DiCara, Danielle, Chan, Nicole, Vessillier, Sandrine, Mather, Stephen J, Rowe, Michelle L, Howard, Mark J, Marshall, John F, Nissim, Ahuva

“…We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used…”
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Poly(Amidoamine)s as Potential Nonviral Vectors:  Ability to Form Interpolyelectrolyte Complexes and to Mediate Transfection in Vitro by Richardson, Simon C. W, Pattrick, Nicola G, Stella Man, Y. K, Ferruti, Paolo, Duncan, Ruth

“…Poly(amidoamine)s (PAAs) are water-soluble polymers that display pH-dependent membrane activity. PAAs have the potential to act as a synthetic alternative to…”
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Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes by Strollo, Rocky, Vinci, Chiara, Man, Y. K. Stella, Bruzzaniti, Sara, Piemonte, Erica, Alhamar, Ghadeer, Briganti, Silvia Irina, Malandrucco, Ilaria, Tramontana, Flavia, Fanali, Chiara, Garnett, James, Buccafusca, Roberto, Guyer, Perrin, Mamula, Mark, James, Eddie A., Pozzilli, Paolo, Ludvigsson, Johnny, Winyard, Paul G., Galgani, Mario, Nissim, Ahuva

“…Aims/hypothesis Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with type 1…”
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Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy by Aguirre-Hernández, Carmen, Maya-Pineda, Héctor, Millán, Julia San, Man, Y. K. Stella, Lu, Yong-Jie, Halldén, Gunnel

“…Anti-apoptotic Bcl-2 is frequently activated in human malignant cells to promote cell survival and inhibit cell death. Replication-selective oncolytic…”
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Systemic delivery and SPECT/CT in vivo imaging of 125 I-labelled oncolytic adenoviral mutants in models of pancreatic cancer by Stella Man, Y K, Foster, Julie, Carapuça, Elisabete, Davies, James A, Parker, Alan L, Sosabowski, Jane, Halldén, Gunnel

“…Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered…”
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Modifying oncolytic viral therapy for pancreatic cancer by Man, Y.K. Stella, Pantelidou, Constantia, Blázquez-Moreno, Alfonso, Coughlan, Lynda, Marshall, John, Kocher, Hemant, Halldén, Gunnel

“…Targeting avb6 -integrin expressing pancreatic cancer cells with oncolytic adenoviral mutants expressing a FMDV peptide (Ad5-FMDV): Diagnosis of pancreatic…”
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