Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kaschin–Beck disease: an epidemiological intervention trial in the Qinghai Province

Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kaschin–Beck disease: an epidemiological intervention trial in the Qinghai Province

Summary Objective Based on the aetiological hypothesis of Kaschin–Beck disease (KBD), different interventions were adopted, and the preventive and therapeutic effects of interventions was observed and evaluated in this trial. Design A total of 358 children from seven villages of Qinghai Province in...

Full description

Saved in:
Bibliographic Details
Published in:Osteoarthritis and cartilage Vol. 22; no. 12; pp. 2033 - 2040
Main Authors: Sun, L.Y, Meng, F.G, Li, Q, Zhao, Z.J, He, C.Z, Wang, S.P, Sa, R.L, Man, W.W, Wang, L.H
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-12-2014
Subjects:
Child
China - epidemiology
Dietary Supplements
Female
Humans
Kaschin–Beck disease
Kashin-Beck Disease - drug therapy
Kashin-Beck Disease - epidemiology
Kashin-Beck Disease - prevention & control
Male
Oryza
Prevention
Rheumatology
Rice
Selenium - administration & dosage
Selenium supplementation
Treatment
China
Prevention
Selenium supplementation
Treatment
Kaschin–Beck disease
Rice
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Objective Based on the aetiological hypothesis of Kaschin–Beck disease (KBD), different interventions were adopted, and the preventive and therapeutic effects of interventions was observed and evaluated in this trial. Design A total of 358 children from seven villages of Qinghai Province in China were examined, and 280 children aged 6–11 years old were eligible for the trial. The children were divided into three groups that received either no intervention ( n  = 64), 150 kg/person of rice from non-KBD areas ( n  = 103) or 7 kg/family of selenium–iodine salt ( n  = 113) for 12 months. Data were collected and used to calculate the proportion of patients with X-ray lesions, the proportion of new patients and the metaphyseal repair rate. All indicators were analysed with Pearson chi-square or Fisher's exact tests. The registration number of this trial is ChiCTR-PNRC-12002309 ( http://www.chictr.org ). Results After interventions, the proportion of patients with X-ray lesions increased dramatically in the control group and decreased significantly in two intervention groups; significant differences were seen between the control group and two intervention groups ( P  < 0.05). Moreover, significant differences were observed in the proportions of new patients and the metaphyseal repair rates between the control group and two intervention groups ( P  < 0.05). Additionally, the proportion of new patients was lowest and the metaphyseal repair rate was highest in group B. Conclusions The effects of eating rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric KBD were notable, the consumption of rice might be the most effective and safest intervention and should be encouraged.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2014.09.013