Search Results - "Man, W. H."

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity by Schafer, P.H., Parton, A., Capone, L., Cedzik, D., Brady, H., Evans, J.F., Man, H.-W., Muller, G.W., Stirling, D.I., Chopra, R.

“…Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in…”
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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis by Schafer, PH, Parton, A, Gandhi, AK, Capone, L, Adams, M, Wu, L, Bartlett, JB, Loveland, MA, Gilhar, A, Cheung, Y‐F, Baillie, GS, Houslay, MD, Man, H‐W, Muller, GW, Stirling, DI

“…Background and purpose:  Apremilast is an orally administered phosphodiesterase‐4 inhibitor, currently in phase 2 clinical studies of psoriasis and other…”
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Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects by DREDGE, K, MARRIOTT, J. B, MACDONALD, C. D, MAN, H-W, CHEN, R, MULLER, G. W, STIRLING, D, DALGLEISH, A. G

“…The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties. Second generation thalidomide analogues are distinct compounds…”
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Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway by Ng, Lui, Chow, Ariel K M, Man, Johnny H W, Yau, Thomas C C, Wan, Timothy M H, Iyer, Deepak N, Kwan, Virginia H T, Poon, Ronnie T P, Pang, Roberta W C, Law, Wai-Lun

“…It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic…”
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Lamina I NK1 Expressing Projection Neurones are Functional in Early Postnatal Rats and Contribute to the Setting up of Adult Mechanical Sensory Thresholds by Man, Sharon HW, Géranton, Sandrine M, Hunt, Stephen P

“…Background: A small proportion of lamina I neurons of the spinal cord project upon the hindbrain and are thought to engage descending pathways that modulate…”
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Development of a nomogram for the estimation of long‐term adherence to clozapine therapy using neutrophil fluorescence by Man, W. H., Pérez‐Pitarch, A., Wilting, I., Heerdink, E. R., Solinge, W. W., Egberts, A. C. G., Huitema, A. D. R.

“…Aims Previously, we have reported an association between clozapine use and elevated FL3 neutrophil fluorescence, a flow‐cytometric parameter for cell…”
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Impact of infant pneumococcal conjugate vaccination on community acquired pneumonia hospitalization in all ages in the Netherlands by van Deursen, A.M.M., Schurink-van't Klooster, T.M., Man, W.H., van de Kassteele, J., van Gageldonk-Lafeber, A.B., Bruijning-Verhagen, P.C.J.L., de Melker, H.E., Sanders, E.A.M., Knol, M.J.

“…•After introduction of PCV CAP hospitalization decreased in Dutch children <2 years.•In children of 2–4 years, the decrease in CAP hospitalization was…”
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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies by Jadhav, Prabhakar K, Woerner, Francis J, Lam, Patrick Y. S, Hodge, C. Nicholas, Eyermann, Charles J, Man, Hon-Wah, Daneker, Wayne F, Bacheler, Lee T, Rayner, Marlene M, Meek, James L, Erickson-Viitanen, Susan, Jackson, David A, Calabrese, Joseph C, Schadt, Margaret, Chang, Chong-Hwan

“…Comparison of the high-resolution X-ray structures of the native HIV-1 protease and its complexes with the inhibitors suggested that the enzyme flaps are…”
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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins by MARRIOTT, J. Blake, CLARKE, Ian A, DALGLEISH, Angus G, CZAJKA, Anna, DREDGE, Keith, CHILDS, Kay, MAN, Hon-Wah, SCHAFER, Peter, GOVINDA, Sowmya, MULLER, George W, STIRLING, David I

“…Thalidomide is clinically useful in a number of cancers. Antitumor activity may be related to a number of known properties, including anti-tumor necrosis…”
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Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma by Chow, Ariel K M, Cheng, Nathan S M, Lam, Colin S C, Ng, Lui, Wong, Sunny K M, Wan, Timothy M H, Man, Johnny H W, Cheung, Alvin H K, Yau, Thomas C C, Poon, Jensen T C, Law, Wai-Lun, Pang, Roberta W C

“…In colorectal carcinoma (CRC), activation of the Raf/MEK/ERK signaling pathway is commonly observed. In addition, the commonly used 5FU-based chemotherapy in…”
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A Highly Enantioselective and Diastereoselective Synthesis of Cyclobutanes via Boronic Esters by Man, Hon-Wah, Hiscox, William C, Matteson, Donald S

“…Deprotonation of enantiopure (R,R)-1,2-dicyclohexyl-1,2-ethanediol 1-chloro-4-cyanobutylboronates 5 with LDA followed by treatment with anhydrous magnesium…”
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Enantiotopic Differentiation of pro-R or pro-S Chlorides in (Dichloromethyl)borates by Chiral Lewis Acids:  Enantioselective Synthesis of (α-Chloroalkyl)boronates by Jadhav, Prabhakar K, Man, Hon-Wah

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Institutionalization of Geographic Information Technologies: Unifying Concept? by de Man, Erik W. H.

“…This paper studies the role, impact, and effectiveness of geographic information technologies such as GIS. Contemporary frameworks-such as economic evaluation,…”
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Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues by PREHN, John L, LANDERS, Carol, MULLER, George W, MAN, Hon-Wah, STIRLING, David I, TARGAN, Stephan R

“…In Crohn's disease, intestinal lamina propria (LP) T cells overproduce TNF-alpha and IFN-gamma, and clinical and animal studies indicate that this is…”
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Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition by GEE, Michael S, MAKONNEN, Sosina, AL-KOFAHI, Khalid, ROYSAM, Badri, PAYVANDI, Faribourz, MAN, Hon-Wah, MULLER, George W, LEE, William M. F

“…Selective cytokine inhibitory drugs (SelCIDs) are a novel class of phosphodiesterase 4 inhibitors discovered during a thalidomide analog discovery program…”
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Understanding SDI; complexity and institutionalization by Erik de Man, W. H.

“…Notwithstanding impressive developments in SDI in exchange, sharing, accessibility, and use of spatial data, its operational implementation appears sometimes…”
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Synthesis of 7-membered cyclic hydroxyguanidines: Novel HIV-1 protease inhibitors by Jadhav, Prabhakar K., Woerner, Francis J., Man, Hon-Wah

“…Novel cyclic 7-membered hydroxyguanidine based HIV-1 protease inhibitors have been synthesized from 7-membered cyclic thiourea. Graphic…”
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Thinking Outside the Disciplinary Box in Coping with Dilemmas in Geoinformation Management for Public Policy by de Man, W.H. Erik

“…Notwithstanding optimistic rhetoric about integrating geospatial data from different sources and supporting good governance, much of the literature on…”
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Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by Chung, Francisco, Palmer, Brian D, Muller, George W, Man, Hon-Wah, Kestell, Phillip, Baguley, Bruce C, Ching, Lai-Ming

“…5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is an antivascular drug that induces tumor necrosis factor (TNF) in mice. Thalidomide inhibits TNF induction by…”
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Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3[beta]/[beta]-catenin pathway by Ng, Lui, Chow, Ariel K. M, Man, Johnny H. W, Yau, Thomas C. C, Wan, Timothy M. H, Iyer, Deepak N, Kwan, Virginia H. T, Poon, Ronnie T. P, Pang, Roberta W. C, Law, Wai-Lun

“…Background It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify…”
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