Search Results - "Man, MQ"

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly by Yang, Bin, Man, Mao-Qiang

“…As we are aging, a number of cutaneous and extracutaneous disorders will be developed. Although the pathogenesis of these aging-associated disorders is not…”
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Topical applications of an emollient reduce circulating pro‐inflammatory cytokine levels in chronically aged humans: a pilot clinical study by Ye, L., Mauro, T.M., Dang, E., Wang, G., Hu, L.Z., Yu, C., Jeong, S., Feingold, K., Elias, P.M., Lv, C.Z., Man, M.Q.

“…Background While increased levels of circulating inflammatory cytokines in chronologically aged humans have been linked to the development of ageing‐associated…”
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The link between cutaneous inflammation and cognitive impairment by Wen, S., Elias, P.M., Wakefield, J.S., Mauro, T.M., Man, M.‐Q.

“…Cognitive impairment is a symptom of neurological disorders, including dementia and Alzheimer's disease; and mild cognitive impairment can be a precursor of…”
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Could Inflammaging and Its Sequelae Be Prevented or Mitigated? by Man, Mao-Qiang, Elias, Peter M

“…Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some…”
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Psoriasis and COVID-19 Infection Negatively Impact Each Other: An Analysis of 3581 Cases by Wang, Xiaohua, Yuan, Liyan, Qiu, Xiaoyu, Yang, Bin, Man, Mao-Qiang

“…To determine whether COVID-19 infection and psoriasis impact each other. WeChat app was used to carry out a questionnaire survey in individuals aged 18 years…”
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Body Mass Index z Scores Correlate with Epidermal Function in Chinese Children by Yang, Bin, Lai, Qingsong, Chen, Aiqi, Ye, Li, Wang, Xiaohua, Lai, Yulin, Liu, Dan, Man, Mao-Qiang

“…Background/Objective: Epidermal function is altered in a number of cutaneous and extracutaneous disorders. To determine whether epidermal function is also…”
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Safety of Biologics for Psoriatic Patients with Latent Tuberculosis by Yuan, Liyan, Li, Yang, Lin, Junjie, Lin, Xiuqiu, Yang, Bin, Man, Mao-Qiang, Wang, Xiaohua

“…Liyan Yuan,* Yang Li,* Junjie Lin, Xiuqiu Lin, Bin Yang, Mao-Qiang Man, Xiaohua Wang Dermatology Hospital, Southern Medical University, Guangzhou, People’s…”
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Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity by Hachem, Jean-Pierre, Man, Mao-Quiang, Crumrine, Debra, Uchida, Yoshikazu, Brown, Barbara E., Rogiers, Vera, Roseeuw, Diane, Feingold, Kenneth R., Elias, Peter M.

“…We showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in permeability barrier homeostasis and SC…”
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Comparison of Epidermal Gene Expression Profiles in Mice Aged 1 to 20 Months by Wang, Xiaohua, Wen, Si, Ye, Li, Liu, Dan, Man, Mao-Qiang, Yang, Bin

“…Although it is well known that epidermal function changes with aging, the transcriptomic basis and possible signaling pathways for aging-associated functional…”
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Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis by Hachem, Jean-Pierre, Houben, Evi, Crumrine, Debra, Man, Mao-Quiang, Schurer, Nanna, Roelandt, Truus, Choi, Eung H., Uchida, Yoshikazu, Brown, Barbara E., Feingold, Kenneth R., Elias, Peter M.

“…Evidence is growing that protease-activated receptor-2 (PAR-2) plays a key role in epithelial inflammation. We hypothesized here that PAR-2 plays a central…”
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Both Age and Disease Duration are Associated with Clinical Phenotype of Hori's Nevus in Chinese: A Retrospective Analysis of 497 Cases by Zhong, Yiping, Huang, Lining, Yan, Tingting, Chen, Yongjun, Yang, Bin, Man, Mao-Qiang

“…Hori's nevus is a common pigmented disorder on the face, preferentially in females. The clinical features have not been well characterized. To characterize the…”
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Mechanisms by Which Psychologic Stress Alters Cutaneous Permeability Barrier Homeostasis and Stratum Corneum Integrity by Choi, Eung-Ho, Brown, Barbara E., Crumrine, Debra, Chang, Sandra, Man, Mao-Qiang, Elias, Peter M., Feingold, Kenneth R.

“…Although many skin disorders, including psoriasis and atopic dermatitis, are adversely affected by psychologic stress (PS), the pathophysiologic link between…”
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Both Prevalence and Severity of Pruritus are Associated with Age in Chinese Patients with Skin Diseases by Wang, Xiaohua, Lai, Qingsong, Zheng, Baoqing, Ye, Li, Wen, Si, Yan, Yunling, Yang, Bin, Man, Mao-Qiang

“…Although the characteristics of pruritus in some skin diseases are documented, characteristics of pruritus related to gender-, age-, and skin disorder have not…”
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Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia: Implications for the Pathogenesis of Psoriasis by Elias, Peter M, Arbiser, Jack, Brown, Barbara E, Rossiter, Heidemarie, Man, Mao-Qiang, Cerimele, Francesca, Crumrine, Debra, Gunathilake, Roshan, Choi, Eung Ho, Uchida, Yoshikazu, Tschachler, Erwin, Feingold, Kenneth R

“…Primary abnormalities in permeability barrier function appear to underlie atopic dermatitis and epidermal trauma; a concomitant barrier dysfunction could also…”
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Short-Term Glucocorticoid Treatment Compromises Both Permeability Barrier Homeostasis and Stratum Corneum Integrity: Inhibition of Epidermal Lipid Synthesis Accounts for Functional Abnormalities by Kao, Jack S., Fluhr, Joachim W., Man, Mao-Qiang, Fowler, Ashley J., Hachem, Jean-Pierre, Crumrine, Debra, Ahn, Sung K., Brown, Barbara E., Elias, Peter M., Feingold, Kenneth R.

“…Prolonged exposure of human epidermis to excess endogenous or exogenous glucocorticoids can result in well-recognized cutaneous abnormalities. Here, we…”
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Prevalence and Severity of Dermatological Condition-Associated Skin Pain in the Chinese by Wang, Xiaohua, Lai, Qingsong, Zheng, Baoqing, Ye, Li, Wen, Si, Yan, Yunling, Yang, Bin, Man, Mao-Qiang

“…Although the characteristics of cutaneous sensory symptoms in the general population have been documented, dermatological condition-associated skin pain has…”
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Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes by Schmuth, Matthias, Haqq, Christopher M., Cairns, William J., Holder, Julie C., Dorsam, Sheri, Chang, Sandra, Lau, Peggy, Fowler, Ashley J., Chuang, Gary, Moser, Arthur H., Brown, Barbara E., Mao-Qiang, Man, Uchida, Yoshikazu, Schoonjans, Kristina, Auwerx, Johan, Chambon, P., Willson, Timothy M., Elias, Peter M., Feingold, Kenneth R.

“…Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have…”
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Regulation of epidermal sphingolipid synthesis by permeability barrier function by Holleran, WM, Feingold, KR, Man, MQ, Gao, WN, Lee, JM, Elias, PM

“…A mixture of sphingolipids, cholesterol, and free fatty acids forms the intercellular membrane bilayers of the stratum corneum which are presumed to regulate…”
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25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis by Bikle, D.D., Chang, S., Crumrine, D., Elalieh, H., Man, M.-Q., Choi, E.H., Dardenne, O., Xie, Z., Arnaud, R. St, Feingold, K., Elias, P.M.

“…Keratinocytes express high levels of 25OHD 1α-hydroxylase (1OHase). The product of this enzyme, 1,25-dihydroxyvitamin D (1,25(OH)2D), promotes the…”
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Is Endogenous Glycerol a Determinant of Stratum Corneum Hydration in Humans? by Choi, Eung Ho, Man, Mao-Qiang, Wang, Fusheng, Zhang, Xinjiang, Brown, Barbara E., Feingold, Kenneth R., Elias, Peter M.

“…Although stratum corneum (SC) hydration has been primarily of concern to the cosmetic industry, it serves an important biosensor function. In murine models,…”
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