Search Results - "Mamula, Mark J."

Autoantigenesis: the evolution of protein modifications in autoimmune disease by Doyle, Hester A, Mamula, Mark J

“…Highlights ► Protein modifications (PTMs) are relevant to the development of autoimmune disease. ► Protein modifications can break immune tolerance. ► Protein…”
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Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology by Yang, Mei-Ling, Sodré, Fernanda M C, Mamula, Mark J, Overbergh, Lut

“…The generation of post-translational modifications (PTMs) in human proteins is a physiological process leading to structural and immunologic variety in…”
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Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes by Yang, Mei-Ling, Kibbey, Richard G, Mamula, Mark J

“…Posttranslational protein modifications (PTMs) are an inherent response to physiological changes causing altered protein structure and potentially modulating…”
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The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes by Piganelli, Jon D, Mamula, Mark J, James, Eddie A

“…Due to their secretory function, β cells are predisposed to higher levels of endoplasmic reticulum (ER) stress and greater sensitivity to inflammation than…”
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Citrullination of glucokinase is linked to autoimmune diabetes by Yang, Mei-Ling, Horstman, Sheryl, Gee, Renelle, Guyer, Perrin, Lam, TuKiet T., Kanyo, Jean, Perdigoto, Ana L., Speake, Cate, Greenbaum, Carla J., Callebaut, Aïsha, Overbergh, Lut, Kibbey, Richard G., Herold, Kevan C., James, Eddie A., Mamula, Mark J.

“…Inflammation, including reactive oxygen species and inflammatory cytokines in tissues amplify various post-translational modifications of self-proteins. A…”
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Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus by Yang, Mei-Ling, Lam, TuKiet T, Kanyo, Jean, Kang, Insoo, Zhou, Zhaohui Sunny, Clarke, Steven G, Mamula, Mark J

“…Protein posttranslational modifications (PTMs) arise in a number of normal cellular biological pathways and in response to pathology caused by inflammation…”
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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement by Lau, Christina M, Broughton, Courtney, Tabor, Abigail S, Akira, Shizuo, Flavell, Richard A, Mamula, Mark J, Christensen, Sean R, Shlomchik, Mark J, Viglianti, Gregory A, Rifkin, Ian R, Marshak-Rothstein, Ann

“…Previous studies (Leadbetter, E.A., I.R. Rifkin, A.H. Hohlbaum, B. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein. 2002. Nature. 416:603-607; Viglianti,…”
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Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer by Doyle, Hester A., Gee, Renelle J., Masters, Tyler D., Gee, Christian R., Booth, Carmen J., Peterson-Roth, Elizabeth, Koski, Raymond A., Helfand, Stuart C., Price, Lauren, Bascombe, Deborah, Jackson, Dorothy, Ho, Rita, Post, Gerald R., Mamula, Mark J.

“…•Spontaneous dog cancers closely resemble human cancer.•Dogs with EGFR associated tumors were immunized with an EGFR/HER2 peptide vaccine.•EGFR peptide…”
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Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes by Perdigoto, Ana Luisa, Deng, Songyan, Du, Katherine C, Kuchroo, Manik, Burkhardt, Daniel B, Tong, Alexander, Israel, Gary, Robert, Marie E, Weisberg, Stuart P, Kirkiles-Smith, Nancy, Stamatouli, Angeliki M, Kluger, Harriet M, Quandt, Zoe, Young, Arabella, Yang, Mei-Ling, Mamula, Mark J, Pober, Jordan S, Anderson, Mark S, Krishnaswamy, Smita, Herold, Kevan C

“…Checkpoint inhibitors (CPIs) targeting programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) have…”
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Post-translational protein modifications in antigen recognition and autoimmunity by Doyle, Hester A, Mamula, Mark J

“…It is estimated that 50–90% of the proteins in the human body are post-translationally modified. In the proper context, these modifications are necessary for…”
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Posttranslational Modifications of Self-Antigens by DOYLE, HESTER A., MAMULA, MARK J.

“…: Although the immune system has developed mechanisms to distinguish “self” from “non‐self,” the presence of autoimmune diseases demonstrates that these…”
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Protein Repair in the Brain, Proteomic Analysis of Endogenous Substrates for Protein L-Isoaspartyl Methyltransferase in Mouse Brain by Zhu, Jeff X., Doyle, Hester A., Mamula, Mark J., Aswad, Dana W.

“…Protein l-isoaspartyl methyltransferase (PIMT) catalyzes repair of l-isoaspartyl peptide bonds, a major source of protein damage under physiological…”
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Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance by James, Eddie A, Pietropaolo, Massimo, Mamula, Mark J

“…Prior to the onset of type 1 diabetes, there is progressive loss of immune self-tolerance, evidenced by the accumulation of islet autoantibodies and emergence…”
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Autoimmunity to isomerized histone H2B in systemic lupus erythematosus by Doyle, Hester A., Aswad, Dana W., Mamula, Mark J.

“…Histone H2B is a common target of autoantibodies in both spontaneous and drug-induced systemic lupus erythematosus (SLE). Recent studies demonstrate that Asp25…”
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Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors by Harvey, Bohdan P, Quan, Timothy E, Rudenga, Benjamin J, Roman, Robert M, Craft, Joe, Mamula, Mark J

“…B lymphocytes can function independently as efficient APCs. However, our previous studies demonstrate that both dendritic cells and macrophages are necessary…”
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Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity by Doyle, Hester A., Zhou, Jing, Wolff, Martin J., Harvey, Bohdan P., Roman, Robert M., Gee, Renelle J., Koski, Raymond A., Mamula, Mark J.

“…A hallmark of the immune system is the ability to ignore self-antigens. In attempts to bypass normal immune tolerance, a post-translational protein…”
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Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse by Zhang, Junhui, Ge, Renshang, Matte-Martone, Catherine, Goodwin, Julie, Shlomchik, Warren D., Mamula, Mark J., Kooshkabadi, Ali, Hardy, Matthew P., Geller, David

“…Glucocorticoids (GCs) exert profound influences on many physiologic functions by virtue of their diverse roles in growth, development, and maintenance of…”
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Antigen presentation and transfer between B cells and macrophages by Harvey, Bohdan P, Gee, Renelle J, Haberman, Ann M, Shlomchik, Mark J, Mamula, Mark J

“…B cells play an active role in directing immunity against specific proteins in part because of their capacity to sequester antigen via B cell receptor (BCR)…”
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Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes by Buitinga, Mijke, Callebaut, Aïsha, Marques Câmara Sodré, Fernanda, Crèvecoeur, Inne, Blahnik-Fagan, Gabriele, Yang, Mei-Ling, Bugliani, Marco, Arribas-Layton, David, Marré, Meghan, Cook, Dana P, Waelkens, Etienne, Mallone, Roberto, Piganelli, Jon D, Marchetti, Piero, Mamula, Mark J, Derua, Rita, James, Eddie A, Mathieu, Chantal, Overbergh, Lut

“…The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes with the generation of neoantigens as potential triggers for…”
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Editorial: B Cells: Not Just Making Immunoglobulin Anymore by Mamula, Mark J.

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