Urinary tract infections in patients with type 2 diabetes mellitus with pharmacological glucosuria

Selective inhibitors of sodium-glucose cotransporter belong to a new class of drugs for the treatment of type 2 diabetes mellitus. The mechanism of their action is based on insulin-independent reduction of glucose reabsorption in the proximal renal tubules, which leads to stimulation of its excretio...

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Bibliographic Details
Published in:	Terapevtic̆eskii arhiv Vol. 92; no. 11; pp. 106 - 109
Main Authors:	Sturov, N V, Popov, S V, Mamporia, N K, Mager, A A
Format:	Journal Article
Language:	English Russian
Published:	Russia (Federation) "Consilium Medicum" Publishing house 26-12-2020
Subjects:	Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Glycosuria - chemically induced Humans Hypoglycemic Agents - adverse effects Sodium-Glucose Transporter 2 Inhibitors - adverse effects type 2 diabetes mellitus type 2 sodium-glucose cotransporter inhibitors urinary tract infections Urinary Tract Infections - drug therapy type 2 diabetes mellitus type 2 sodium-glucose cotransporter inhibitors urinary tract infections
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Summary:	Selective inhibitors of sodium-glucose cotransporter belong to a new class of drugs for the treatment of type 2 diabetes mellitus. The mechanism of their action is based on insulin-independent reduction of glucose reabsorption in the proximal renal tubules, which leads to stimulation of its excretion in the urine and, accordingly, to a decrease in the concentration of glucose in the blood plasma. Drugs of this group demonstrate effectiveness in the treatment of type 2 diabetes, but their use may be associated with an increased frequency of urinary tract infections. Pharmacological glucosuria, which leads to a decrease in the concentration of glucose in the blood, creates the preconditions for the occurrence of urinary tract infections. Urinary tract and genital infections are the most common adverse events associated with the use of sodium-glucose cotransporter inhibitors. In the presented literature review for 20162019, the relationship between urinary tract infections in patients with type 2 diabetes mellitus and therapy with sodium-glucose cotransporter inhibitors was analyzed.
ISSN:	0040-3660 2309-5342
DOI:	10.26442/00403660.2020.11.000581