Search Results - "Mamede, João I"

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection by Dharan, Adarsh, Talley, Sarah, Tripathi, Abhishek, Mamede, João I, Majetschak, Matthias, Hope, Thomas J, Campbell, Edward M

“…Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the target cell and undergoes a series of trafficking and replicative…”
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Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection by Wong, Richard W, Mamede, João I, Hope, Thomas J

“…It has been known for a number of years that integration sites of human immunodeficiency virus type 1 (HIV-1) DNA show a preference for actively expressed…”
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HIV Infection and Spread between Th17 Cells by Zayas, Janet P., Mamede, João I.

“…HIV mainly targets CD4+ T cells, from which Th17 cells represent a major cell type, permissive, and are capable of supporting intracellular replication at…”
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Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid by Sultana, Tahmina, Mamede, João I, Saito, Akatsuki, Ode, Hirotaka, Nohata, Kyotaro, Cohen, Romy, Nakayama, Emi E, Iwatani, Yasumasa, Yamashita, Masahiro, Hope, Thomas J, Shioda, Tatsuo

“…Type I interferons (IFNs), including alpha IFN (IFN-α) and IFN-β, potently suppress HIV-1 replication by upregulating IFN-stimulated genes (ISGs). The viral…”
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Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA by Yoh, Sunnie M., Mamede, João I., Lau, Derrick, Ahn, Narae, Sánchez-Aparicio, Maria T., Temple, Joshua, Tuckwell, Andrew, Fuchs, Nina V., Cianci, Gianguido C., Riva, Laura, Curry, Heather, Yin, Xin, Gambut, Stéphanie, Simons, Lacy M., Hultquist, Judd F., König, Renate, Xiong, Yong, García-Sastre, Adolfo, Böcking, Till, Hope, Thomas J., Chanda, Sumit K.

“…We have previously described polyglutamine-binding protein 1 (PQBP1) as an adapter required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response to…”
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Multiple expansions of globally uncommon SARS-CoV-2 lineages in Nigeria by Ozer, Egon A., Simons, Lacy M., Adewumi, Olubusuyi M., Fowotade, Adeola A., Omoruyi, Ewean C., Adeniji, Johnson A., Olayinka, Oluseyi A., Dean, Taylor J., Zayas, Janet, Bhimalli, Pavan P., Ash, Michelle K., Maiga, Almoustapha I., Somboro, Anou M., Maiga, Mamoudou, Godzik, Adam, Schneider, Jeffrey R., Mamede, João I., Taiwo, Babafemi O., Hultquist, Judd F., Lorenzo-Redondo, Ramon

“…Disparities in SARS-CoV-2 genomic surveillance have limited our understanding of the viral population dynamics and may delay identification of globally…”
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Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response by Ash, Michelle K., Bhimalli, Pavan P., Cho, Byoung-Kyu, Mattamana, Basil Baby, Gambut, Stéphanie, Tarhoni, Imad, Fhied, Cristina L., Reyes, Anjelica F., Welninski, Samantha J., Arivalagan, Jaison, Negrão, Fernanda, Goel, Renu, Beck, Todd L., Hope, Thomas J., Sha, Beverly E., Goo, Young Ah, Al-Harthi, Lena, Mamede, João I., Borgia, Jeffrey A., Kelleher, Neil L., Schneider, Jeffrey R.

“…Although vaccination efforts have expanded, there are still gaps in our understanding surrounding the immune response to SARS-CoV-2. Measuring IgG Fc…”
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Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts by Sharma, Aabha I., Olson, Cheryl L., Mamede, João I., Gazos-Lopes, Felipe, Epting, Conrad L., Almeida, Igor C., Engman, David M.

“…Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations of sterol-rich…”
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Cyclophilins and nucleoporins are required for infection mediated by capsids from circulating HIV-2 primary isolates by Mamede, João I., Damond, Florence, Bernardo, Ariel de, Matheron, Sophie, Descamps, Diane, Battini, Jean-Luc, Sitbon, Marc, Courgnaud, Valérie

“…HIV-2 groups have emerged from sooty mangabey SIV and entered the human population in Africa on several separate occasions. Compared to world pandemic HIV-1…”
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The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation in Human Lung Cells and Inflammatory Cytokine Production in Human Lung and Intestinal Epithelial Cells by Forsyth, Christopher B, Zhang, Lijuan, Bhushan, Abhinav, Swanson, Barbara, Zhang, Li, Mamede, Jo? I, Voigt, Robin M, Shaikh, Maliha, Engen, Phillip A, Keshavarzian, Ali

“…The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan, China, with a new coronavirus designated SARS-CoV-2. The principal cause of…”
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Early cytoplasmic uncoating is associated with infectivity of HIV-1 by Mamede, João I., Cianci, Gianguido C., Anderson, Meegan R., Hope, Thomas J.

“…After fusion, HIV delivers its conical capsid into the cytoplasm. To release the contained reverse-transcribing viral genome, the capsid must disassemble in a…”
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Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo by Carter, Stephen D., Mamede, João I., Hope, Thomas J., Jensen, Grant J.

“…Members of the tripartite motif (TRIM) protein family have been shown to assemble into structures in both the nucleus and cytoplasm. One TRIM protein family…”
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Infectious Virus Tracking by Fluorescent Live Cell Imaging in Primary Cells by Gambut, Stephanie, Hope, Thomas J, Mamede, João I

“…To successfully infect a cell, HIV-1 has to overcome several host barriers while exploiting cellular cofactors. HIV-1 infection is highly inefficient with the…”
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Detection and Tracking of Dual-Labeled HIV Particles Using Wide-Field Live Cell Imaging to Follow Viral Core Integrity by Mamede, João I, Hope, Thomas J

“…Live cell imaging is a valuable technique that allows the characterization of the dynamic processes of the HIV-1 life cycle. Here, we present a method of…”
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A New Generation of Functional Tagged Proteins for HIV Fluorescence Imaging by Mamede, João I, Griffin, Joseph, Gambut, Stéphanie, Hope, Thomas J

“…During the last decade, there was a marked increase in the development of tools and techniques to study the molecular mechanisms of the HIV replication cycle…”
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De novo emergence of SARS‐CoV‐2 spike mutations in immunosuppressed patients by Simons, Lacy M., Ozer, Egon A., Gambut, Stephanie, Dean, Taylor J., Zhang, Li, Bhimalli, Pavan, Schneider, Jeffrey R., Mamede, João I., Ison, Michael G., Karmali, Reem, Gordon, Leo I., Lorenzo‐Redondo, Ramon, Hultquist, Judd F.

“…Background The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants with decreased susceptibility to neutralizing…”
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Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells by Carter, Stephen D., Mageswaran, Shrawan K., Farino, Zachary J., Mamede, João I., Oikonomou, Catherine M., Hope, Thomas J., Freyberg, Zachary, Jensen, Grant J.

“…In cryogenic correlated light and electron microscopy (cryo-CLEM), frozen targets of interest are identified and located on EM grids by fluorescence microscopy…”
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Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy by Martin-Sancho, Laura, Tripathi, Shashank, Rodriguez-Frandsen, Ariel, Pache, Lars, Sanchez-Aparicio, Maite, McGregor, Michael J., Haas, Kelsey M., Swaney, Danielle L., Nguyen, Thong T., Mamede, João I., Churas, Christopher, Pratt, Dexter, Rosenthal, Sara B., Riva, Laura, Nguyen, Courtney, Beltran-Raygoza, Nish, Soonthornvacharin, Stephen, Wang, Guojun, Jimenez-Morales, David, De Jesus, Paul D., Moulton, Hong M., Stein, David A., Chang, Max W., Benner, Chris, Ideker, Trey, Albrecht, Randy A., Hultquist, Judd F., Krogan, Nevan J., García-Sastre, Adolfo, Chanda, Sumit K.

“…The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To…”
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Heterogeneous susceptibility of circulating SIV isolate capsids to HIV-interacting factors by Mamede, João I, Sitbon, Marc, Battini, Jean-Luc, Courgnaud, Valérie

“…Many species of non-human primates in Africa are naturally infected by simian immunodeficiency viruses (SIV) and humans stand at the forefront of exposure to…”
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HIV Infection and Spread between Th 17 Cells by Zayas, Janet P, Mamede, João I

“…HIV mainly targets CD4 T cells, from which Th cells represent a major cell type, permissive, and are capable of supporting intracellular replication at mucosal…”
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