Search Results - "Mamdouh, Mohamed A."

Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review by Mohamed, Mamdouh F. A, Abuo-Rahma, Gamal El-Din A

“…α,β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of…”
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Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats by M. Soliman, Sara, Mosallam, Shaimaa, Mamdouh, Mohamed A., Hussein, Mohammed Abdalla, M. Abd El-Halim, Shady

“…Cranberry extract (CBE) is a major source of the antioxidant polyphenolics but suffers from limited bioavailability. The goal of this research was to…”
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Insights on magnetic spinel ferrites for targeted drug delivery and hyperthermia applications by Abdel Maksoud, Mohamed Ibrahim Ahmed, Ghobashy, Mohamed Mohamady, Kodous, Ahmad S., Fahim, Ramy Amer, Osman, Ahmed I., Al-Muhtaseb, Ala’a H., Rooney, David W., Mamdouh, Mohamed A., Nady, Norhan, Ashour, Ahmed H.

“…Magnetic spinel ferrite nanoparticles (SFNPs) attract high scientific attention from researchers due to their broad area for biomedicine applications,…”
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Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats by Sheta, Nermin M., Boshra, Sylvia A., Mamdouh, Mohamed A., Abdel-Haleem, Khaled M.

“…The present study aimed to develop fast melting tablets (FMTs) using silymarin (SM) owing to FMTs rapid disintegration and dissolution. FMTs represent a…”
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Targeting the NF-κB p65/Bcl-2 signaling pathway in hepatic cellular carcinoma using radiation assisted synthesis of zinc nanoparticles coated with naturally isolated gallic acid by AboZaid, Omayma A.R., Abdel-Maksoud, Mostafa A., Saleh, Ibrahim A., El-Tayeb, Mohamed A., EL-sonbaty, Sawsan M., Shoker, Faten E., Salem, Maha A., Emad, Ayat M., Mani, Samson, Deva Magendhra Rao, Arunagiri Kuha, Mamdouh, Mohamed A., Kotob, Mohamed H., Aufy, Mohammed, Kodous, Ahmad S.

“…Oral diethylnitrosamine (DEN) is a known hepatocarcinogen that damages the liver and causes cancer. DEN damages the liver through reactive oxygen…”
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Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents by Ahmed, Eman A, Mohamed, Mamdouh F. A, Omran, Omran A

“…Novel quinoxaline derivatives ( 2a-d , 3 , 4a , 4b and 5-15 ) have been synthesized via the reaction of 4-methyl-3-oxo-3,4-dihydroquinoxaline-2-carbohydrazide…”
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Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4 H )-Oxazolone-Based Sulfonamides by Almalki, Ahmad J, Ibrahim, Tarek S, Taher, Ehab S, Mohamed, Mamdouh F A, Youns, Mahmoud, Hegazy, Wael A H, Al-Mahmoudy, Amany M M

“…Since the synthesis of prontosil the first prodrug shares their chemical moiety, sulfonamides exhibit diverse modes of actions to serve as antimicrobials,…”
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Effect of Cu+/2+ ions on the biological activity of their bis‐oxalyldihydrazone complexes: ctDNA interaction, antimicrobial and anticancer action by Adam, Mohamed Shaker S., Mohamed, Mamdouh A.

“…Two bimetallic homoleptic complexes (CuL1 and CuL2) were synthesized from the coordination of Cu+/2+ ions with diisatin oxalyldihydrazone ligand (H2Lx),…”
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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs by Abuo-Rahma, Gamal El-Din A, Mohamed, Mamdouh F. A, Ibrahim, Tarek S, Shoman, Mai E, Samir, Ebtihal, Abd El-Baky, Rehab M

“…The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people…”
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Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors by Ibrahim, Tarek S, Malebari, Azizah M, Mohamed, Mamdouh F A

“…Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR)…”
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Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction by Ibrahim, Tarek S., Moustafa, Amr H., Almalki, Ahmad J., Allam, Rasha M., Althagafi, Abdulhamid, Md, Shadab, Mohamed, Mamdouh F. A.

“…Two series of chalcone/aryl carboximidamide hybrids 4a-f and 6a-f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most…”
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Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves by Hassan, Heba Ali, Allam, Ahmed E, Abu-Baih, Dalia H, Mohamed, Mamdouh F A, Abdelmohsen, Usama Ramadan, Shimizu, Kuniyoshi, Desoukey, Samar Y, Hayallah, Alaa M, Elrehany, Mahmoud A, Mohamed, Khaled M, Kamel, Mohamed S

“…Metabolic profiling of the crude methanolic extract of leaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides…”
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Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand by Adam, Mohamed Shaker S., Makhlouf, Mohamed M., Mohamed, Mamdouh A., Desoky M. Mohamad, Ahmed

“…Mononucleating complexes of isatin hydrazone sodium sulfonate ligand (HLn) with palladium (II) and cobalt (II) ions: The complexes were synthesized within 1:1…”
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Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study by Shady, Nourhan Hisham, Hayallah, Alaa M, Mohamed, Mamdouh F A, Ghoneim, Mohammed M, Chilingaryan, Garri, Al-Sanea, Mohammad M, Fouad, Mostafa A, Kamel, Mohamed Salah, Abdelmohsen, Usama Ramadan

“…Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this…”
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Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer by Khayyat, Ahdab N., Abbas, Hisham A., Mohamed, Mamdouh F. A., Asfour, Hani Z., Khayat, Maan T., Ibrahim, Tarek S., Youns, Mahmoud, Khafagy, El-Sayed, Abu Lila, Amr S., Safo, Martin K., Hegazy, Wael A. H.

“…Diabetic foot ulcers are recognized to be a severe complication of diabetes, increasing the risk of amputation and death. The bacterial infection of Diabetic…”
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In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors by Ibrahim, Tarek S, Taher, Ehab S, Samir, Ebtihal, M Malebari, Azizah, Khayyat, Ahdab N, Mohamed, Mamdouh F A, Bokhtia, Riham M, AlAwadh, Mohammed A, Seliem, Israa A, Asfour, Hani Z, Alhakamy, Nabil A, Panda, Siva S, Al-Mahmoudy, Amany M M

“…Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good…”
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Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl 2 in rats by Sheta, Nermin M, Boshra, Sylvia A, Mamdouh, Mohamed A, Abdel-Haleem, Khaled M

“…The present study aimed to develop fast melting tablets (FMTs) using silymarin (SM) owing to FMTs rapid disintegration and dissolution. FMTs represent a…”
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Diagnostic Accuracy of Placental Thickness in Lower Uterine Segment Measured by Ultrasound in Prediction of Placenta Accreta Spectrum in Patients with Placenta Previa. A Diagnostic Test Accuracy Study by Elmaraghy, Ahmed Mohammed, Taha Fayed, Salah, Abd ElHamid Ali, Mahmoud, Ali Hassanien, Monira, Mohamed Mamdouh, Ahmed

“…The aim of the study was to evaluate the association between placental thickness and placenta accreta spectrum (PAS) in patients with placenta previa. In this…”
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The Potential Synergistic Activity of Zolmitriptan Combined in New Self-Nanoemulsifying Drug Delivery Systems: ATR-FTIR Real-Time Fast Dissolution Monitoring and Pharmacodynamic Assessment by Abd El-Halim, Shady M, Mamdouh, Mohamed A, Eid, Sherif M, Ibrahim, Bassant M M, Aly Labib, Dina A, Soliman, Sara M

“…The current work aimed to overcome the poor permeability and undesirable adverse effects of Zolmitriptan (ZMT) and to increase its efficacy in the treatment of…”
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Fabrication of Anti-HSV-1 Curcumin Stabilized Nanostructured Proniosomal Gel: Molecular Docking Studies on Thymidine Kinase Proteins by El-Halim, Shady M. Abd, Mamdouh, Mohamed A., El-Haddad, Alaadin E., Soliman, Sara M.

“…Curcumin is a dietary compound with accrued evidence of antiviral activity. Poor solubility and permeation renders curcumin a good applicant for incorporation…”
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