Search Results - "Mamdani, Firoza"

Identification of potential blood biomarkers associated with suicide in major depressive disorder by Mamdani, Firoza, Weber, Matthieu D., Bunney, Blynn, Burke, Kathleen, Cartagena, Preston, Walsh, David, Lee, Francis S., Barchas, Jack, Schatzberg, Alan F., Myers, Richard M., Watson, Stanley J., Akil, Huda, Vawter, Marquis P., Bunney, William E., Sequeira, Adolfo

“…Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and…”
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Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression by Sequeira, Adolfo, Mamdani, Firoza, Ernst, Carl, Vawter, Marquis P, Bunney, William E, Lebel, Veronique, Rehal, Sonia, Klempan, Tim, Gratton, Alain, Benkelfat, Chawki, Rouleau, Guy A, Mechawar, Naguib, Turecki, Gustavo

“…Most studies investigating the neurobiology of depression and suicide have focused on the serotonergic system. While it seems clear that serotonergic…”
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The somatic common deletion in mitochondrial DNA is decreased in schizophrenia by Mamdani, Firoza, Rollins, Brandi, Morgan, Ling, Sequeira, P. Adolfo, Vawter, Marquis P

“…Abstract Large deletions in mitochondrial DNA (mtDNA) can occur during or result from oxidative stress leading to a vicious cycle that increases reactive…”
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Blood-based biomarkers for suicide in depression: moving a step closer to prediction by Mamdani, Firoza, Sequeira, Adolfo

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Medial prefrontal cortex activity during memory encoding of pictures and its relation to symptomatic improvement after citalopram treatment in patients with major depression by Roy, Martin, MD, Harvey, Philippe-Olivier, MSc, Berlim, Marcelo T., MD, MSc, Mamdani, Firoza, BSc, Beaulieu, Marie-Martine, MSc, Turecki, Gustavo, MD, PhD, Lepage, Martin, PhD

“…Background Brain imaging studies of major depressive disorder have shown alterations in the brain regions typically involved in episodic memory, including the…”
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No association between the PREP gene and lithium responsive bipolar disorder by Mamdani, Firoza, Sequeira, Adolfo, Alda, Martin, Grof, Paul, Rouleau, Guy, Turecki, Gustavo

“…Bipolar disorder (BD) is a major psychiatric condition that commonly requires prophylactic and episodic treatment. Lithium (Li) has been used for over 40 years…”
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Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission by Limon, Agenor, Mamdani, Firoza, Hjelm, Brooke E, Vawter, Marquis P, Sequeira, Adolfo

“…Major depressive disorder (MDD) is a leading cause of disability worldwide characterized by altered neuronal activity in brain regions involved in the control…”
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Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications by Mamdani, Firoza, Jaitovich Groisman, Iris, Alda, Martin, Turecki, Gustavo

“…The importance of genes in the etiology of bipolar disorder has been substantiated through family, twin, and adoption studies. Bipolar disorder is treated at…”
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Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders by Hjelm, Brooke E, Rollins, Brandi, Morgan, Ling, Sequeira, Adolfo, Mamdani, Firoza, Pereira, Filipe, Damas, Joana, Webb, Michelle G, Weber, Matthieu D, Schatzberg, Alan F, Barchas, Jack D, Lee, Francis S, Akil, Huda, Watson, Stanley J, Myers, Richard M, Chao, Elizabeth C, Kimonis, Virginia, Thompson, Peter M, Bunney, William E, Vawter, Marquis P

“…Deletions in the 16.6 kb mitochondrial genome have been implicated in numerous disorders that often display muscular and/or neurological symptoms due to the…”
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Lithium response and genetic variation in the CREB family of genes by Mamdani, Firoza, Alda, Martin, Grof, Paul, Young, L. Trevor, Rouleau, Guy, Turecki, Gustavo

“…Bipolar disorder (BD) is a severe psychiatric disorder that affects 1% of the population. Recently, there have been many attempts to identify specific genes…”
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Pharmacogenomic predictors of citalopram treatment outcome in major depressive disorder by Mamdani, Firoza, Berlim, Marcelo T., Beaulieu, Marie-Martine, Turecki, Gustavo

“…Abstract Objectives. A significant proportion of patients with major depressive disorder (MDD) do not improve following treatment with first-line…”
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Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses by de Lara, Catalina Lopez, Jaitovich-Groisman, Iris, Cruceanu, Cristiana, Mamdani, Firoza, Lebel, Véronique, Yerko, Volodymyr, Beck, Angus, Young, L. Trevor, Rouleau, Guy, Grof, Paul, Alda, Martin, Turecki, Gustavo

“…Several chromosomal regions have been linked to bipolar disorder (BD). However, the search for specific genes has been hampered by inconsistent findings,…”
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Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia by Vawter, Marquis P., Moon, Emily A., Robinson, Delbert G., Rollins, Brandi, Lencz, Todd, Martin, Maureen V., Mamdani, Firoza, Malhotra, Anil K.

“…Mood disorders and schizophrenia are common and complex disorders with consistent evidence of genetic and environmental influences on predisposition. It is…”
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An integrative functional genomics approach for discovering biomarkers in schizophrenia by Vawter, Marquis P., Mamdani, Firoza, Macciardi, Fabio

“…Schizophrenia (SZ) is a complex disorder resulting from both genetic and environmental causes with a lifetime prevalence world-wide of 1%; however, there are…”
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A Genomic Investigation of Major Depressive Disorder and Antidepressant Response by Mamdani, Firoza

“…Major depressive disorder (MDD) is a common and complex disorder with consistent evidence of genetic influence on predisposition. The search for susceptibility…”
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Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia by Hjelm, Brooke E, Rollins, Brandi, Mamdani, Firoza, Lauterborn, Julie C, Kirov, George, Lynch, Gary, Gall, Christine M, Sequeira, Adolfo, Vawter, Marquis P

“…Genetic evidence has supported the hypothesis that schizophrenia (SZ) is a polygenic disorder caused by the disruption in function of several or many genes…”
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Alpha 2A adrenergic receptor gene and suicide by Sequeira, Adolfo, Mamdani, Firoza, Lalovic, Aleksandra, Anguelova, Milena, Lesage, Alain, Seguin, Monique, Chawky, Nadia, Desautels, Alex, Turecki, Gustavo

“…Suicide is a complex trait resulting from the interaction of several predisposing factors, among which genes seem to play an important role. Alterations in the…”
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Genetic variation and lithium response in bipolar disorder by Mamdani, Firoza

“…The importance of genes in the etiology of bipolar disorder (BD) has been substantiated through family, twin and adoption studies. The search for…”
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A Genomic Investigation of Major Depressive Disorder and Antidepressant Response by Mamdani, Firoza

“…Major depressive disorder (MDD) is a common and complex disorder with consistent evidence of genetic influence on predisposition. The search for susceptibility…”
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Pharmacogenomic predictors of citalopram treatment outcome in major depressive disorder by Mamdani, Firoza, Berlim, Marcelo T., Beaulieu, Marie-Martine, Turecki, Gustavo

“…Objectives. A significant proportion of patients with major depressive disorder (MDD) do not improve following treatment with first-line antidepressants and,…”
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