Search Results - "Maltby, David A."

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry by Vosseller, Keith, Trinidad, Jonathan C., Chalkley, Robert J., Specht, Christian G., Thalhammer, Agnes, Lynn, Aenoch J., Snedecor, June O., Guan, Shenheng, Medzihradszky, Katalin F., Maltby, David A., Schoepfer, Ralf, Burlingame, Alma L.

“…O-GlcNAc is a widespread dynamic carbohydrate modification of cytosolic and nuclear proteins with features analogous to phosphorylation. O-GlcNAc acts…”
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Proteomics Analysis Reveals Post-Translational Mechanisms for Cold-Induced Metabolic Changes in Arabidopsis by Li, Tian, Xu, Shou-Ling, Oses-Prieto, Juan A., Putil, Sunita, Xu, Peng, Wang, Rui-Ju, Li, Kathy H., Maltby, David A., An, Liz-He, Burlingame, Alma L., Deng, Zhi-Ping, Wang, Zhi-Yong

“…Cold-induced changes of gene expression and metabolism are critical for plants to survive freezing. Largely by changing gene expression, exposure to a period…”
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Global landscape of HIV–human protein complexes by Jäger, Stefanie, Cimermancic, Peter, Gulbahce, Natali, Johnson, Jeffrey R., McGovern, Kathryn E., Clarke, Starlynn C., Shales, Michael, Mercenne, Gaelle, Pache, Lars, Li, Kathy, Hernandez, Hilda, Jang, Gwendolyn M., Roth, Shoshannah L., Akiva, Eyal, Marlett, John, Stephens, Melanie, D’Orso, Iván, Fernandes, Jason, Fahey, Marie, Mahon, Cathal, O’Donoghue, Anthony J., Todorovic, Aleksandar, Morris, John H., Maltby, David A., Alber, Tom, Cagney, Gerard, Bushman, Frederic D., Young, John A., Chanda, Sumit K., Sundquist, Wesley I., Kortemme, Tanja, Hernandez, Ryan D., Craik, Charles S., Burlingame, Alma, Sali, Andrej, Frankel, Alan D., Krogan, Nevan J.

“…Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human…”
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Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding by Coan, Kristin E. D, Maltby, David A, Burlingame, Alma L, Shoichet, Brian K

“…One of the leading sources of false positives in early drug discovery is the formation of organic small molecule aggregates, which inhibit enzymes…”
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Expanding Proteome Coverage with Orthogonal-specificity α-Lytic Proteases by Meyer, Jesse G., Kim, Sangtae, Maltby, David A., Ghassemian, Majid, Bandeira, Nuno, Komives, Elizabeth A.

“…Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that…”
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Global identification of peptidase specificity by multiplex substrate profiling by O'Donoghue, Anthony J, Eroy-Reveles, A Alegra, Knudsen, Giselle M, Ingram, Jessica, Zhou, Min, Statnekov, Jacob B, Greninger, Alexander L, Hostetter, Daniel R, Qu, Gang, Maltby, David A, Anderson, Marc O, DeRisi, Joseph L, McKerrow, James H, Burlingame, Alma L, Craik, Charles S

“…A synthetic peptide library in conjunction with liquid chromatography–tandem mass spectrometry identifies the specificities of endo- and exopeptidases without…”
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Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase by Babaoglu, Kerim, Simeonov, Anton, Irwin, John J, Nelson, Michael E, Feng, Brian, Thomas, Craig J, Cancian, Laura, Costi, M. Paola, Maltby, David A, Jadhav, Ajit, Inglese, James, Austin, Christopher P, Shoichet, Brian K

“…High-throughput screening (HTS) is widely used in drug discovery. Especially for screens of unbiased libraries, false positives can dominate “hit lists”; their…”
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Covalent Intermediate in the Catalytic Mechanism of the Radical S‑Adenosyl‑l‑methionine Methyl Synthase RlmN Trapped by Mutagenesis by McCusker, Kevin P, Medzihradszky, Katalin F, Shiver, Anthony L, Nichols, Robert J, Yan, Feng, Maltby, David A, Gross, Carol A, Galonić Fujimori, Danica

“…The posttranscriptional modification of ribosomal RNA (rRNA) modulates ribosomal function and confers resistance to antibiotics targeted to the ribosome. The…”
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The Identification of Protein-Protein Interactions of the Nuclear Pore Complex of Saccharomyces cerevisiae Using High Throughput Matrix-assisted Laser Desorption Ionization Time-of-Flight Tandem Mass Spectrometry by Huang, Lan, Baldwin, Michael A, Maltby, David A, Medzihradszky, Katalin F, Baker, Peter R, Allen, Nadia, Rexach, Michael, Edmondson, Ricky D, Campbell, Jennifer, Juhasz, Peter, Martin, Steven A, Vestal, Marvin L, Burlingame, Alma L

“…Mass spectrometry has become the technology of choice for detailed identification of proteins in complex mixtures. Although electrophoretic separation,…”
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An antibiotic factory caught in action by Stroud, Robert M, Keatinge-Clay, Adrian T, Maltby, David A, Medzihradszky, Katalin F, Khosla, Chaitan

“…The synthesis of aromatic polyketides, such as actinorhodin, tetracycline and doxorubicin, begins with the formation of a polyketide chain. In type II…”
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Spin Scavenging Analysis of Myoglobin Protein-Centered Radicals Using Stable Nitroxide Radicals: Characterization of Oxoammonium Cation-Induced Modifications by Lardinois, Olivier M, Maltby, David A, Medzihradszky, Katalin F, de Montellano, Paul R. Ortiz, Tomer, Kenneth B, Mason, Ronald P, Deterding, Leesa J

“…Spin scavenging combined with chromatographic and mass spectrometric procedures can, in principle, be employed to detect and identify protein-based radicals…”
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Autocatalytic Processing of Heme by Lactoperoxidase Produces the Native Protein-bound Prosthetic Group by DePillis, G D, Ozaki, S i, Kuo, J M, Maltby, D A, Ortiz de Montellano, P R

“…The covalently bound prosthetic group of lactoperoxidase (LPO) has been obtained by hydrolysis of the protein and identified as a dihydroxylated heme. A…”
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Stereoisomer effects on the Paal-Knorr synthesis of pyrroles by Szakal-Quin, Gyongyi, Graham, Doyle G, Millington, David S, Maltby, David A, McPhail, Andrew T

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Covalent Intermediate in the Catalytic Mechanism of the Radical SAM Methyl Synthase RlmN Trapped by Mutagenesis by McCusker, Kevin P., Medzihradszky, Katalin F., Shiver, Anthony L., Nichols, Robert J., Yan, Feng, Maltby, David A., Gross, Carol A., Fujimori, Danica Galonić

“…The posttranscriptional modification of ribosomal RNA (rRNA) modulates ribosomal function and confers resistance to antibiotics targeted to the ribosome. The…”
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Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-CoA dehydrogenase deficiency by ROE, C. R, MILLINGTON, D. S, MALTBY, D. A, BOHAN, T. P, KAHLER, S. G, CHALMERS, R. A

“…The medium-chain acyl-coA dehydrogenase deficiency is one of several metabolic disorders presenting clinically as Reye syndrome. Evidence is presented for a…”
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Capillary supercritical fluid chromatography-mass spectrometry using a "high mass" quadrupole and splitless injection by Pinkston, J. David, Owens, Grover D, Burkes, Leisa J, Delaney, Thomas E, Millington, David S, Maltby, David A

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Chemical contamination and the annual summer die-off of striped bass (Morone saxatilis) in the Sacramento-San Joaquin Delta by Cashman, John R, Maltby, David A, Nishioka, Richard S, Bern, Howard A, Gee, Shirley J, Hammock, Bruce D

“…In 1987, striped bass (Morone saxatilis) that were nearly dead (moribund) were captured by hand net, and apparently healthy striped bass were caught by hook…”
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Differentiation of isomeric acyl carnitines using tandem mass spectrometry by Gaskell, Simon J, Guenat, Christian, Millington, David S, Maltby, David A, Roe, Charles R

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Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor by Liao, Mingxiang, Pabarcus, Michael K, Wang, YongQiang, Hefner, Colleen, Maltby, David A, Medzihradszky, Katalin F, Salas-Castillo, Saida Patricia, Yan, James, Maher, Jacquelyn J, Correia, Maria Almira

“…Tryptophan 2,3-dioxygenase (TDO), a liver-specific cytosolic hemoprotein, is the rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic…”
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Derivatization of hydrophilic peptides for liquid secondary ion mass spectrometry at the picomole level by Falick, A M, Maltby, D A

“…A simple procedure for preparing alkyl and benzyl esters of peptides is described. The procedure can provide an increase in the secondary ion yield of a factor…”
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