A novel rapid throughput phototolerance screen in mice

A novel rapid throughput phototolerance screen in mice

A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance...

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Bibliographic Details
Published in:Journal of pharmacological and toxicological methods Vol. 36; no. 4; pp. 185 - 187
Main Authors: Shapiro, Martin A., Sesnie, Josephine C., Joannides, E.Themis, Malta, Thomas E., Dever, Julie A., Heifetz, Carl L.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-12-1996
Subjects:
Animals
Dermatitis, Phototoxic - etiology
Drug Evaluation, Preclinical - methods
Female
Mice
Mice, Inbred Strains
Mouse model
Phototolerance
Quinolones - toxicity
Rapid screening method
Skin Diseases - chemically induced
Skin Diseases - etiology
Toxicology - methods
Mouse model
Rapid screening method
Phototolerance
Online Access:Get full text
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Description
Summary:A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance screen established for that purpose. It also reports phototolerance data with standard reference drugs obtained using this screen.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1056-8719
1873-488X
DOI:10.1016/S1056-8719(96)00109-8