Search Results - "Malspeis, L"

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data by BAI, R, PAULL, K. D, HERALD, C. L, MALSPEIS, L, PETTIT, G. R, HAMEL, E

“…Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60 human tumor cell lines, were…”
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Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS by Rice, William G., Supko, Jeffrey G., Malspeis, Louis, Buckheit, Robert W., Clanton, David, Bu, Ming, Graham, Lisa, Schaeffer, Catherine A., Turpin, Jim A., Domagala, John, Gogliotti, Rocco, Bader, John P., Halliday, Susan M., Coren, Lori, Sowder, Raymond C., Arthur, Larry O., Henderson, Louis E.

“…Strategies for the treatment of human immunodeficiency virus-type 1 (HIV-1) infection must contend with the obstacle of drug resistance. HIV-1 nucleocapsid…”
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Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells by DREES, M, DENGLER, W. A, ROTH, T, LABONTE, H, MAYO, J, MALSPEIS, L, GREVER, M, SAUSVILLE, E. A, FIEBIG, H. H

“…We have selected a panel of human tumor xenografts for in vitro and in vivo studies that allows an indication of selectivity of action of novel…”
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Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton by Senderowicz, A M, Kaur, G, Sainz, E, Laing, C, Inman, W D, Rodríguez, J, Crews, P, Malspeis, L, Grever, M R, Sausville, E A

“…Jasplakinolide, a cyclodepsipeptide produced by an Indo-Pacific sponge, Jaspis johnstoni, has been reported to inhibit the growth of breast cancer cells. The…”
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Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog by Phillips, L R, Malspeis, L, Supko, J G

“…The monocyclic terpene d-limonene, a major component in many citrus essential oils (1-3), has been used for many years as a flavoring agent, food additive, and…”
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Pharmacokinetics of michellamine B, a naphthylisoquinoline alkaloid with in vitro activity against human immunodeficiency virus types 1 and 2, in the mouse and dog by SUPKO, J. G, MALSPEIS, L

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model by Casciari, J J, Hollingshead, M G, Alley, M C, Mayo, J G, Malspeis, L, Miyauchi, S, Grever, M R, Weinstein, J N

“…Cancer treatments that appear promising in tissue culture are often less effective in solid tumors, in part because of the proliferative and microenvironmental…”
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Pharmacokinetics of 2-F-ara-A (9-beta-D-arabinofuranosyl-2-fluoroadenine) in cancer patients during the phase I clinical investigation of fludarabine phosphate by Malspeis, L, Grever, M R, Staubus, A E, Young, D

“…Fludara I.V. (fludarabine phosphate) (2-F-ara-adenosine monophosphate [2-F-ara-AMP], NSC 312887) is the 5'-phosphate of…”
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Analysis of brefeldin A and the prodrug breflate in plasma by gas chromatography with mass selective detection by Phillips, L.R, Wolfe, T.L, Malspeis, L, Supko, J.G

“…Breflate is a water soluble prodrug developed to facilitate parenteral administration of the investigational antineoplastic agent brefeldin A (BFA)…”
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Plasma pharmacokinetics and bioavailability of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea after intravenous and oral administration to mice and dogs by SUPKO, Jeffrey G, GARCIA-CARBONERO, Rocio, PUCHALSKI, Thomas A, MALSPEIS, Louis

“…Chloroethylnitrosoureas are among the most widely used chemotherapeutic agents for the treatment of brain tumors. SarCNU…”
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Dose-dependent pharmacokinetics of rapamycin-28-N,N-dimethylglycinate in the mouse by Supko, J G, Malspeis, L

“…Rapamycin-28-N,N-dimethylglycinate methanesulfonate salt (RG), synthesized as a potential water-soluble prodrug to facilitate parenteral administration of the…”
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Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5500 with altered glycoprotein expression in vitro by BURGER, A. M, KAUR, G, HOLLINGSHEAD, M, FISCHER, R. T, NAGASHIMA, K, MALSPEIS, L, DUNCAN, K. L. K, SAUSVILLE, E. A

“…The spicamycin analogue KRN5500 (NSC 650426; SPA) is derived from Streptomyces alanosinicus. The unique structure contains a purine, an aminoheptose sugar,…”
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Analysis of brefeldin A in plasma by gas chromatography with electron capture detection by Phillips, L R, Supko, J G, Malspeis, L

“…The National Cancer Institute (NCI) is pursuing preclinical development of Brefeldin A (BFA), a macrolide isolated from Penicillium brefeldianum, as an…”
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Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1 by Buckheit, Jr, R W, Hollingshead, M, Stinson, S, Fliakas-Boltz, V, Pallansch, L A, Roberson, J, Decker, W, Elder, C, Borgel, S, Bonomi, C, Shores, R, Siford, T, Malspeis, L, Bader, J P

“…A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1, and…”
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A comprehensive phase I and II clinical investigation of fludarabine phosphate by Grever, M, Leiby, J, Kraut, E, Metz, E, Neidhart, J, Balcerzak, S, Malspeis, L

“…This article presents data from the phase I and II clinical investigations of Fludara I.V. (fludarabine phosphate) (NSC 312887), which is the 5'-phosphorylated…”
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Determination of michellamine B in biological fluids by high-performance liquid chromatography with fluorescence detection by Supko, J G, Malspeis, L

“…The National Cancer Institute is pursuing preclinical development of michellamine B (MB), a novel dimeric polyhydroxylated naphthalene-tetrahydroisoquinoline…”
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Concomitant adsorption and stability of some anthracycline antibiotics by Tomlinson, E, Malspeis, L

“…Using liquid scintillation counting and liquid chromatographic techniques, it has been demonstrated that the anthracycline antibiotics, doxorubicin…”
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Characterization of the urinary metabolites of merbarone in cancer patients by Supko, J G, Malspeis, L

“…Phase-I clinical trials in cancer patients of merbarone (MB), a thiobarbituric acid derivative with curative activity against the murine leukemias, were…”
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The discovery and development of new antileukemic drugs by Grever, M, Malspeis, L

“…Despite the major advances that have been made over the past few decades in the management of adult acute leukemia, a substantial number of the patients still…”
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Kinetics and mechanism of thiolytic cleavage of the antitumor compound 4'-[(9-acridinyl)amino]methanesulfon-m-anisidide by Khan, M. Niyaz, Malspeis, L

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