Search Results - "Maloney, Susan E."

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo by Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.

“…Tau aggregation occurs in neurodegenerative diseases including Alzheimer’s disease and many other disorders collectively termed tauopathies. trans-cellular…”
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Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? by Dougherty, Joseph D., Marrus, Natasha, Maloney, Susan E., Yip, Benjamin, Sandin, Sven, Turner, Tychele N., Selmanovic, Din, Kroll, Kristen L., Gutmann, David H., Constantino, John N., Weiss, Lauren A.

“…Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a “female protective effect” (FPE) envisions males and females have…”
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Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain by Sakers, Kristina, Liu, Yating, Llaci, Lorida, Lee, Scott M., Vasek, Michael J., Rieger, Michael A., Brophy, Sean, Tycksen, Eric, Lewis, Renate, Maloney, Susan E., Dougherty, Joseph D.

“…Quaking RNA binding protein (QKI) is essential for oligodendrocyte development as myelination requires myelin basic protein mRNA regulation and localization by…”
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Fluoxetine exposure throughout neurodevelopment differentially influences basilar dendritic morphology in the motor and prefrontal cortices by Maloney, Susan E., Tabachnick, Dora R., Jakes, Christine, Avdagic, Selma, Bauernfeind, Amy L., Dougherty, Joseph D.

“…The significance of serotonin (5HT) in mental health is underscored by the serotonergic action of many classes of psychiatric medication. 5HT is known to have…”
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Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis by Weston, Kellan P., Gao, Xiaoyi, Zhao, Jinghan, Kim, Kwang-Soo, Maloney, Susan E., Gotoff, Jill, Parikh, Sumit, Leu, Yen-Chen, Wu, Kuen-Phon, Shinawi, Marwan, Steimel, Joshua P., Harrison, Joseph S., Yi, Jason J.

“…The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to…”
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The trajectory of gait development in mice by Akula, Shyam K., McCullough, Katherine B., Weichselbaum, Claire, Dougherty, Joseph D., Maloney, Susan E.

“…Objective Gait irregularities are prevalent in neurodevelopmental disorders (NDDs). However, there is a paucity of information on gait phenotypes in NDD…”
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Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7 by Meganathan, Kesavan, Prakasam, Ramachandran, Baldridge, Dustin, Gontarz, Paul, Zhang, Bo, Urano, Fumihiko, Bonni, Azad, Maloney, Susan E, Turner, Tychele N, Huettner, James E, Constantino, John N, Kroll, Kristen L

“…Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs…”
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Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits by Beard, Diana C., Zhang, Xiyun, Wu, Dennis Y., Martin, Jenna R., Erickson, Alyssa, Boua, Jane Valeriane, Hamagami, Nicole, Swift, Raylynn G., McCullough, Katherine B., Ge, Xia, Bell-Hensley, Austin, Zheng, Hongjun, Palmer, Cory W., Fuhler, Nicole A., Lawrence, Austin B., Hill, Cheryl A., Papouin, Thomas, Noguchi, Kevin K., McAlinden, Audrey, Garbow, Joel R., Dougherty, Joseph D., Maloney, Susan E., Gabel, Harrison W.

“…Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct…”
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Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB by McCullough, Katherine B, Titus, Amanda, Reardon, Kate, Conyers, Sara, Dougherty, Joseph D, Ge, Xia, Garbow, Joel R, Dickson, Patricia, Yuede, Carla M, Maloney, Susan E

“…Mucopolysaccharidosis (MPS) IIIB, also known as Sanfilippo Syndrome B, is a devastating childhood disease. Unfortunately, there are currently no available…”
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Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation by Dalal, Jasbir, Roh, Jee Hoon, Maloney, Susan E, Akuffo, Afua, Shah, Samir, Yuan, Han, Wamsley, Brie, Jones, Wendell B, de Guzman Strong, Cristina, Gray, Paul A, Holtzman, David M, Heintz, Nathaniel, Dougherty, Joseph D

“…Hypocretin (orexin; Hcrt)-containing neurons of the hypothalamus are essential for the normal regulation of sleep and wake behaviors and have been implicated…”
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Ontogenetic Oxycodone Exposure Affects Early Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice by Minakova, Elena, Sarafinovska, Simona, Mikati, Marwa O, Barclay, Kia M, McCullough, Katherine B, Dougherty, Joseph D, Al-Hasani, Ream, Maloney, Susan E

“…Nationwide, opioid misuse among pregnant women has risen four-fold from 1999 to 2014, with commensurate increase in neonates hospitalized for neonatal…”
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Characterization of early communicative behavior in mouse models of neurofibromatosis type 1 by Maloney, Susan E., Chandler, Krystal C., Anastasaki, Corina, Rieger, Michael A., Gutmann, David H., Dougherty, Joseph D.

“…Neurofibromatosis type 1 (NF1) is a monogenic neurodevelopmental disease caused by germline loss‐of‐function mutations in the NF1 tumor suppressor gene…”
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Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome by Cheng, Cheng, Deng, Pan-Yue, Ikeuchi, Yoshiho, Yuede, Carla, Li, Daofeng, Rensing, Nicholas, Huang, Ju, Baldridge, Dustin, Maloney, Susan E., Dougherty, Joseph D., Constantino, John, Jahani-Asl, Arezu, Wong, Michael, Wozniak, David F., Wang, Ting, Klyachko, Vitaly A., Bonni, Azad

“…Mutations of the transcriptional regulator PHF6 cause the X-linked intellectual disability disorder Börjeson-Forssman-Lehmann syndrome (BFLS), but the…”
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Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders by Rahn, Rachel M, Weichselbaum, Claire T, Gutmann, David H, Dougherty, Joseph D, Maloney, Susan E

“…Motor deficits such as abnormal gait are an underappreciated yet characteristic phenotype of many neurodevelopmental disorders (NDDs), including Williams…”
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Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring by Giri, Tusar, Maloney, Susan E., Giri, Saswat, Goo, Young Ah, Song, Jong Hee, Son, Minsoo, Tycksen, Eric, Conyers, Sara B., Bice, Annie, Ge, Xia, Garbow, Joel R., Quirk, James D., Bauer, Adam Q., Palanisamy, Arvind

“…Despite six decades of the use of exogenous oxytocin for management of labor, little is known about its effects on the developing brain. Motivated by…”
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Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure by Maloney, Susan E, Akula, Shyam, Rieger, Michael A, McCullough, Katherine B, Chandler, Krystal, Corbett, Adrian M, McGowin, Audrey E, Dougherty, Joseph D

“…Serotonergic dysregulation is implicated in numerous psychiatric disorders. Serotonin plays widespread trophic roles during neurodevelopment; thus…”
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Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models by Kopp, Nathan, McCullough, Katherine, Maloney, Susan E, Dougherty, Joseph D

“…Williams syndrome (WS) is a neurodevelopmental disorder caused by a 1.5-1.8 Mbp deletion on chromosome 7q11.23, affecting the copy number of 26-28 genes…”
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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo by Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.

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Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre -Expressing Neurons by McGill, Bryan E, Barve, Ruteja A, Maloney, Susan E, Strickland, Amy, Rensing, Nicholas, Wang, Peter L, Wong, Michael, Head, Richard, Wozniak, David F, Milbrandt, Jeffrey

“…CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying 3D chromatin structure. Human mutations…”
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Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties by Hanzel, Michalina, Fernando, Kayla, Maloney, Susan E, Horn, Zachi, Gong, Shiaoching, Mätlik, Kärt, Zhao, Jiajia, Pasolli, H Amalia, Heissel, Søren, Dougherty, Joseph D, Hull, Court, Hatten, Mary E

“…Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar…”
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