Search Results - "Malone, Kyle"

The immune system and stroke: from current targets to future therapy by Malone, Kyle, Amu, Sylvie, Moore, Anne C, Waeber, Christian

“…Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search for new therapies, hundreds of agents targeting various…”
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Flow cytometry and stroke: from current methodology to future applications by Amu, Sylvie, Malone, Kyle

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Immunomodulatory Therapeutic Strategies in Stroke by Malone, Kyle, Amu, Sylvie, Moore, Anne C, Waeber, Christian

“…The role of immunity in all stages of stroke is increasingly being recognized, from the pathogenesis of risk factors to tissue repair, leading to the…”
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Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds by Malone, Kyle, Dugas, Melanie, Earl, Nathalie, Alain, Tommy, LaCasse, Eric C., Beug, Shawn T.

“…Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects…”
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The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia by Malone, Kyle, Diaz Diaz, Andrea C, Shearer, Jennifer A, Moore, Anne C, Waeber, Christian

“…The role of the immune system in stroke is well-recognised. Fingolimod, an immunomodulatory agent licensed for the management of relapsing-remitting multiple…”
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A comparison of perioperative charges and outcome between open and mini-open approaches for anterior lumbar discectomy and fusion by Smith, William D, Christian, Ginger, Serrano, Sherrie, Malone, Kyle T

“…Abstract The objectives of this study were to examine charge data and long-term outcomes of two approaches for anterior lumbar interbody fusion: a mini-open…”
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Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities by Diaz Diaz, Andrea C., Malone, Kyle, Shearer, Jennifer A., Moore, Anne C., Waeber, Christian

“…Preclinical data indicate that fingolimod improves outcome post-ischaemia. This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in…”
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Acute Treatment With Fingolimod Does Not Confer Long-Term Benefit in a Mouse Model of Intracerebral Haemorrhage by Diaz Diaz, Andrea C, Shearer, Jennifer A, Malone, Kyle, Waeber, Christian

“…Intracerebral haemorrhage (ICH) has no specific treatment, but accounts for up to 15% of all strokes and has the highest mortality. Fingolimod (FTY720) is an…”
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Suspension-Induced Stem Cell Transition: A Non-Transgenic Method to Generate Adult Stem Cells from Mouse and Human Somatic Cells by Yeganeh, Behzad, Yeganeh, Azadeh, Malone, Kyle, Beug, Shawn T, Jankov, Robert P

“…Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities…”
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Biomechanical Evaluation of a Novel Autogenous Bone Interbody Fusion Cage for Posterior Lumbar Interbody Fusion in a Cadaveric Model by Wang, Le, Malone, Kyle T, Huang, Hai, Zhang, Zhenshan, Zhang, Zhi, Zhang, Liang, Li, Jian

“…A human cadaveric biomechanical study of a novel, prefabricated autogenous bone interbody fusion (ABIF) cage. To evaluate the biomechanical properties of the…”
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Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer by Zahedi-Amiri, Ali, Malone, Kyle, Beug, Shawn T, Alain, Tommy, Yeganeh, Behzad

“…Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control…”
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Postoperative Radiotherapy for Prostate Cancer: A Comparison of Four Consensus Guidelines and Dosimetric Evaluation of 3D-CRT Versus Tomotherapy IMRT by Malone, Shawn, M.D., F.R.C.P.C, Croke, Jennifer, M.D, Roustan-Delatour, Nicolas, M.D, Belanger, Eric, M.D., F.R.C.P.C, Avruch, Leonard, M.D., F.R.C.P.C, Malone, Colin, Morash, Christopher, M.D., F.R.C.S.C, Kayser, Cathleen, M.R.T.(T.), Underhill, Kathryn, B.Sc.(Hons.), Li, Yan, Malone, Kyle, Nyiri, Balazs, Ph.D, Spaans, Johanna, M.Sc

“…Purpose Despite the benefits of adjuvant radiotherapy after radical prostatectomy, approximately one-half of patients relapse. Four consensus guidelines have…”
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Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia by Malone, Kyle, Shearer, Jennifer A., Williams, John M., Moore, Anne C., Moore, Tom, Waeber, Christian

“…The well-characterised role of the immune system in acute ischaemic stroke has prompted the search for immunomodulatory therapies. Pregnancy-specific…”
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Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1 by Hoang, Huy-Dung, Said, Aida, Vaidya, Nasana, Gilchrist, Victoria H, Malone, Kyle, Kabilan, Usha, Topshee, Serena, Xiang, Xiao, Yang, An-Dao, Olagnier, David, Mossman, Karen, Beug, Shawn T, Jafarnejad, Seyed Mehdi, Workenhe, Samuel T, Graber, Tyson E, Alain, Tommy

“…BackgroundTransgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be…”
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Minimally invasive lateral approaches for the treatment of spinal tumors: single-position surgery without the “flip” by Laratta, Joseph L., Weegens, Ryan, Malone, Kyle T., Chou, Dean, Smith, William D.

“…Although primary tumors of the spine and neural elements are rare, metastatic disease to the spine is quite common. Traditionally, surgical treatment for…”
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Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE−/− mice in the presence and absence of immunomodulation with fingolimod by Diaz Diaz, Andrea C., Malone, Kyle, Shearer, Jennifer A., Moore, Anne C., Waeber, Christian

“…In this work, the sphingosine-1-phosphate receptor modulator fingolimod was assessed as a preclinical candidate for the treatment of acute ischaemic stroke…”
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Chromosome Damage and Cell Proliferation Rates in In Vitro Irradiated Whole Blood as Markers of Late Radiation Toxicity After Radiation Therapy to the Prostate by Beaton, Lindsay A., MSc, Ferrarotto, Catherine, MLT, Marro, Leonora, MSc, Samiee, Sara, MD, Malone, Shawn, MD, Grimes, Scott, Malone, Kyle, Wilkins, Ruth C., PhD

“…Purpose In vitro irradiated blood samples from prostate cancer patients showing late normal tissue damage were examined for lymphocyte response by measuring…”
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Minimally invasive lateral extracavitary resection of foraminal neurofibromas by Dakwar, Elias, Smith, William D, Malone, Kyle T, Uribe, Juan S

“…Abstract Nerve sheath tumors are the most common spinal tumors but extradural foraminal nerve sheath tumors are much rarer. Traditionally, these nerve sheath…”
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Cell death in glioblastoma and the central nervous system by Malone, Kyle, LaCasse, Eric, Beug, Shawn T.

“…Abstract Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is characterized by significant intra- and inter-tumoral heterogeneity,…”
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The impact of fingolimod on Treg function in brain ischaemia by Malone, Kyle, Shearer, Jennifer A, Waeber, Christian, Moore, Anne C

“…Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested the hypothesis that fingolimod modulates T-cell cytokine production…”
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