Search Results - "Malo, P. E."

Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Basha, Anwer, Craig, Richard A, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and…”
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Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic Acids as Leukotriene Biosynthesis Inhibitors by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Woods, Keith W, Gane, Todd, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as leukotriene biosynthesis inhibitors. A hypothesis of…”
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Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors by Bell, R L, Bouska, J B, Malo, P E, Lanni, C, Harris, R R, Otis, E R, Stewart, A O, Brooks, D W, Carter, G W

“…As in vitro glucuronidation assay and several biochemical assays were utilized to discover potent new N-hydroxyurea-containing 5-lipoxygenase inhibitors with…”
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Chronological relationships between mediator release and changes in airway dynamics during an ascaris response in sensitive cynomolgus monkeys by Malo, P E

“…Recently identified Ascaris suum sensitive cynomolgus monkeys were further characterized to determine if a chronologic relationship existed between mediator…”
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Specific enhancement of LTD4-induced contractions of isolated guinea pig trachea by 5-hydroxyeicosatetraenoic acid (5-HETE) by Malo, P E

“…In view of the likely production of monohydroxyeicosatetraenoic acids (HETEs) in bronchial asthma, the role of these lipoxygenase products in the development…”
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Design of inhibitors of leukotriene biosynthesis and their therapeutic potential by Brooks, C. D. W., Stewart, A. O., Kolasa, Teodozyj, Basha, A., Bhatia, Pramila, Ratajczyk, J. D., Craig, R. A., Gunn, David, Harris, R. R., Bouska, J. B., Malo, P. E., Bell, R. L., Carter, G. W.

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Preclinical and clinical activity of zileuton and A-78773 by Bell, R L, Lanni, C, Malo, P E, Brooks, D W, Stewart, A O, Hansen, R, Rubin, P, Carter, G W

“…The importance of leukotrienes as mediators of inflammation and bronchoconstriction was examined with two recently described 5-lipoxygenase inhibitors,…”
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Leukotriene D4 (LTD4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium by Hoffstein, S T, Malo, P E, Bugelski, P, Wheeldon, E B

“…To study the potential role of leukotriene (LTD4) as a mucus secretagogue, anesthetized and spontaneously breathing guinea pigs were intubated and challenged…”
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Characterization of substance P-induced contractions of guinea-pig trachea by Malo, P E, Wasserman, M A, Torphy, T J, Parris, D J, Pfeiffer, D F

“…In light of current interest in substance P as a bronchoconstrictor, several pharmacologic antagonists of known mediators of anaphylaxis were tested for…”
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Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis by Bell, R L, Harris, R R, Bouska, J B, Hulkower, K I, Moore, J, Bhatia, P, Malo, P E, Kalosa, T, Brooks, C D, Carter, G W

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Effects of intravenous and aerosol nifedipine on prostaglandin F2 alpha and histamine-induced bronchoconstriction in anesthetized dogs by Malo, P E, Wasserman, M A, Griffin, R L

“…The effect of nifedipine, a calcium slow channel blocking drug, was investigated by varying routes of administration in a canine model of pharmacologically…”
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The effect of calcium antagonists on histamine and leukotriene-induced tracheal microvascular permeability in the guinea pig by Malo, P E, Wasserman, M A

“…The effects of several calcium antagonists, i.e., nifedipine, verapamil and 8-[N,N-diethylamino]-octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8), were…”
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Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor by Malo, P E, Wasserman, M A, Pfeiffer, D F

“…The effect of platelet activating factor (PAF), a potent lipid mediator of inflammation, was examined in the induction of airway hyperreactivity to known…”
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The properties of A-69412: a small hydrophilic 5-lipoxygenase inhibitor by Bell, R L, Bouska, J, Young, P R, Lanni, C, Machinist, J, Malo, P E, Summers, J B, Brooks, D W, Carter, G W

“…A compound which inhibits leukotriene biosynthesis could be clinically useful in treating several allergic and inflammatory diseases. One site for such…”
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The effects of nifedipine and verapamil on antigen-induced bronchoconstriction in dogs by Malo, P E, Wasserman, M A, Griffin, R L

“…The effects of calcium channel blockers, nifedipine and verapamil (i.v. and aerosol), were investigated in beagle dogs natively allergic to Ascaris suum…”
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(R)-(+)-N-[3-[5-[4-fluorophenylmethyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor by BROOKS, C. D. W, STEWART, A. O, HARRIS, R. R, MALO, P. E, CARTER, G. W, BELL, R. L, BASHA, A, BHATIA, P, RATAJCZYK, J. D, MARTIN, J. G, CRAIG, R. A, KOLASA, T, BOUSKA, J. B, LANNI, C

“…Structure-activity optimization of inhibitory potency and duration of action of N-hydroxyurea containing 5-lipoxygenase inhibitors was conducted. The…”
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The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis by Albert, D H, Malo, P E, Tapang, P, Shaughnessy, T K, Morgan, D W, Wegner, C D, Curtin, M L, Sheppard, G S, Xu, L, Davidsen, S K, Summers, J B, Carter, G W

“…Platelet-activating factor (PAF) may be an important mediator of allergic rhinitis. In the present study we evaluated the effectiveness of a recently described…”
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ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents by Bell, R L, Harris, R R, Malo, P E, Bouska, J B, Shaughnessy, T K, Hulkower, K I, Brooks, C D, Carter, G W

“…Our primary goal has been to discover leukotriene biosynthesis inhibitors with characteristics that are appropriate for use as clinical agents. The success of…”
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The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis by Malo, P E, Bell, R L, Shaughnessy, T K, Summers, J B, Brooks, D W, Carter, G W

“…Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in…”
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A-78773: a selective, potent 5-lipoxygenase inhibitor by Bell, R L, Brooks, D W, Young, P R, Lanni, C, Stewart, A O, Bouska, J, Malo, P E, Carter, G W

“…The potency and selectivity of A-78773, a newly discovered 5-lipoxygenase inhibitor, were examined. The compound was significantly more potent than zileuton in…”
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