Search Results - "Malmsheimer, Silke"
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1
Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems
Published in Nature communications (27-08-2018)“…Many bacteria export effector proteins fulfilling their function in membranes of a eukaryotic host. These effector membrane proteins appear to contain signals…”
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2
Bartonella taylorii: A Model Organism for Studying Bartonella Infection in vitro and in vivo
Published in Frontiers in microbiology (15-07-2022)“…Bartonella spp. are Gram-negative facultative intracellular pathogens that infect diverse mammals and cause a long-lasting intra-erythrocytic bacteremia in…”
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3
Self-establishing communities enable cooperative metabolite exchange in a eukaryote
Published in eLife (26-10-2015)“…Metabolite exchange among co-growing cells is frequent by nature, however, is not necessarily occurring at growth-relevant quantities indicative of…”
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4
Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease
Published in Scientific reports (17-08-2017)“…PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires…”
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5
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones
Published in Virulence (31-12-2022)“…Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers…”
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Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells
Published in FEMS microbiology letters (01-10-2018)“…Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells. They are able to secrete…”
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The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors
Published in PLoS pathogens (15-11-2024)“…To promote intracellular survival and infection, Legionella spp . translocate hundreds of effector proteins into eukaryotic host cells using a type IV b…”
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Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis
Published in mBio (30-10-2024)“…Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are…”
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Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak
Published in Journal of cell science (01-06-2016)“…The pro-apoptotic multidomain Bcl-2 proteins Bax and Bak (also known as BAK1) are considered the gatekeepers of the intrinsic pathway of apoptosis by…”
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Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak
Published in Journal of cell science (01-08-2016)Get full text
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Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak and augments drug response
Published in Journal of cell science (01-01-2016)“…The pro-apoptotic multidomain Bcl-2 proteins Bax and Bak are considered the gatekeepers of the intrinsic pathway of apoptosis by triggering the mitochondrial…”
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Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates
Published in Nature microbiology (01-09-2023)“…Mycobacteriophages show promise as therapeutic agents for non-tuberculous mycobacterium infections. However, little is known about phage recognition of…”
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13
B21 Ribosomal transcription is regulated by PGC-1alpha and disturbed in huntington’s disease
Published in Journal of neurology, neurosurgery and psychiatry (01-09-2016)“…Background/aimsPGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP…”
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