Search Results - "Mallucci, G R"

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity by Halliday, M, Radford, H, Sekine, Y, Moreno, J, Verity, N, le Quesne, J, Ortori, C A, Barrett, D A, Fromont, C, Fischer, P M, Harding, H P, Ron, D, Mallucci, G R

“…Activation of the PERK branch of the unfolded protein response (UPR) in response to protein misfolding within the endoplasmic reticulum (ER) results in the…”
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Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease by Celardo, I, Costa, A C, Lehmann, S, Jones, C, Wood, N, Mencacci, N E, Mallucci, G R, Loh, S H Y, Martins, L M

“…Mutations in PINK1 and PARKIN cause early-onset Parkinson’s disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1…”
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Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration by Mallucci, G.R., Ratté, S., Asante, E.A., Linehan, J., Gowland, I., Jefferys, J.G.R., Collinge, J.

“…Prion protein (PrP) plays a crucial role in prion disease, but its physiological function remains unclear Mice with gene deletions restricted to the coding…”
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Inherited prion disease with an alanine to valine mutation at codon 117 in the prion protein gene by Mallucci, G. R., Campbell, T. A., Dickinson, A., Beck, J., Holt, M., Plant, G., de Pauw, K. W., Hakin, R. N., Clarke, C. E., Howell, S., Davies-Jones, G. A. B., Lawden, M., Smith, C. M. L., Ince, P., Ironside, J. W., Bridges, L. R., Dean, A., Weeks, I., Collinge, J.

“…A large English family with autosomal dominant segregation of presenile dementia, ataxia and other neuropsychiatric features is described. Diagnoses of…”
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Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory by Halliday, Mark, Mallucci, Giovanna R.

“…Recent evidence has placed the unfolded protein response (UPR) at the centre of pathological processes leading to neurodegenerative disease. The translational…”
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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing by Boland, Barry, Yu, Wai Haung, Corti, Olga, Mollereau, Bertrand, Henriques, Alexandre, Bezard, Erwan, Pastores, Greg M., Rubinsztein, David C., Nixon, Ralph A., Duchen, Michael R., Mallucci, Giovanna R., Kroemer, Guido, Levine, Beth, Eskelinen, Eeva-Liisa, Mochel, Fanny, Spedding, Michael, Louis, Caroline, Martin, Olivier R., Millan, Mark J.

“…Neurodegenerative disorders of ageing such as Alzheimer disease, Parkinson disease and Huntington disease are characterized by the presence of neurotoxic…”
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Can mutations of prion protein shed light on its normal function? by Mallucci, Giovanna R

“…Around 15% of all prion diseases arise due to dominantly inherited mutations in the PRNP gene, which encodes the ubiquitously expressed, highly conserved prion…”
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Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration by Mallucci, G.R., Ratté, S., Asante, E.A., Linehan, J., Gowland, I., Jefferys, J.G.R., Collinge, J.

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Neuropsychiatric presentations of prion disease by Mallucci, Giovanna R, Collinge, John

“…The past year has seen the emergence of a new variant of Creutzfeldt-Jakob disease reported in 10 young people. The probability that transmission of bovine…”
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