Search Results - "Malloy, Allison MW"

Distinct innate signaling and activation of dendritic cells during the neonatal period determines their functional response to respiratory syncytial virus infection by Lau-Kilby, Annie W, Kehl, Margaret, Malloy, Allison MW

“…Dendritic cells (DCs) are among the first to respond to infection, providing the critical link between innate and adaptive immunity. Neonates often have weak…”
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Differential antigen presentation and transport by neonatal and adult dendritic cell subsets during Respiratory Syncytial Virus (RSV) infection by Lau-Kilby, Annie W, Kehl, Margaret, Malloy, Allison MW

“…Dendritic cells (DCs) are critical for the induction of anti-viral CD8+ T cells. Young infants mount poor antiviral responses contributing to increased disease…”
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Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus-Specific CD8+ T Cell Immunodominance Hierarchy in Neonates by Malloy, Allison M W, Ruckwardt, Tracy J, Morabito, Kaitlyn M, Lau-Kilby, Annie W, Graham, Barney S

“…Young infants are generally more susceptible to viral infections and experience more severe disease than do adults. CD8 T cells are important for viral…”
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Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice by Ruckwardt, Tracy J, Malloy, Allison M W, Gostick, Emma, Price, David A, Dash, Pradyot, McClaren, Jennifer L, Thomas, Paul G, Graham, Barney S

“…Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant…”
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Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response: e1003934 by Ruckwardt, Tracy J, Malloy, Allison MW, Morabito, Kaitlyn M, Graham, Barney S

“…CD103+ and CD11b+ populations of CD11c+MHCIIhi murine dendritic cells (DCs) have been shown to carry antigens from the lung through the afferent lymphatics to…”
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Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope by Ruckwardt, Tracy J, Luongo, Cindy, Malloy, Allison M W, Liu, Jie, Chen, Man, Collins, Peter L, Graham, Barney S

“…CD8(+) T cell responses are critical for the control of virus infections. Following infection, epitope-specific responses establish an unpredictable but…”
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Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice by Rahman, M Jubayer, Rodrigues, Kameron B, Quiel, Juan A, Liu, Yi, Bhargava, Vipul, Zhao, Yongge, Hotta-Iwamura, Chie, Shih, Han-Yu, Lau-Kilby, Annie W, Malloy, Allison Mw, Thoner, Timothy W, Tarbell, Kristin V

“…Type I IFN (IFN-I) dysregulation contributes to type 1 diabetes (T1D) development, and although increased IFN-I signals are pathogenic at the initiation of…”
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CD8+ TCR Transgenic Strains Expressing Public versus Private TCR Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Demonstrate Similar Functional Profiles: e99249 by Bar-Haim, Erez, Erez, Noam, Malloy, Allison MW, Graham, Barney S, Ruckwardt, Tracy J

“…Our previous work has characterized the functional and clonotypic features of two respiratory syncytial virus (RSV) epitope-specific T cell responses in mice…”
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