Search Results - "Mallorga, Pierre"

N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity by Sur, Cyrille, Mallorga, Pierre J., Wittmann, Marion, Jacobson, Marlene A., Pascarella, Danette, Williams, Jacinta B., Brandish, Philip E., Pettibone, Douglas J., Scolnick, Edward M., Conn, P. Jeffrey

“…The molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia remain elusive. The…”
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The Glycine Transporter Type 1 Inhibitor N-[3-(4'-Fluorophenyl)-3-(4'-Phenylphenoxy)Propyl]Sarcosine Potentiates NMDA Receptor-Mediated Responses In Vivo and Produces an Antipsychotic Profile in Rodent Behavior by Kinney, Gene G, Sur, Cyrille, Burno, Maryann, Mallorga, Pierre J, Williams, Jacinta B, Figueroa, David J, Wittmann, Marion, Lemaire, Wei, Conn, P. Jeffrey

“…Glycine acts as a necessary coagonist for glutamate at the NMDA receptor (NMDAR) complex by binding to the strychnine-insensitive glycine-B binding site on the…”
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The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin by Pettibone, Douglas J, Hess, J Fred, Hey, Patricia J, Jacobson, Marlene A, Leviten, Michael, Lis, Edward V, Mallorga, Pierre J, Pascarella, Danette M, Snyder, Melissa A, Williams, Jacinta B, Zeng, Zhizhen

“…Mice deficient in the neurotensin (NT)-1 receptor (NTR1) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT…”
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Pharmacology and expression analysis of glycine transporter GlyT1 with [ 3H]-(N-[3-(4′-fluorophenyl)-3-(4′phenylphenoxy)propyl])sarcosine by Mallorga, Pierre J, Williams, Jacinta B, Jacobson, Marlene, Marques, Rosemary, Chaudhary, Ashok, Conn, P.Jeffrey, Pettibone, Douglas J, Sur, Cyrille

“…In the central nervous system, re-uptake of the neurotransmitter glycine is mediated by two different glycine transporters, GlyT1 and GlyT2. GlyT2 is found in…”
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Effects of typical and atypical antipsychotics on human glycine transporters by Williams, Jacinta B., Mallorga, Pierre J., Jeffrey Conn, P., Pettibone, Douglas J., Sur, Cyrille

“…Augmentation strategy in the treatment of schizophrenia with the NMDA receptor co-agonist glycine has demonstrated significant improvement in patient symptoms…”
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Development of a scintillation proximity assay for analysis of Na +/Cl −-dependent neurotransmitter transporter activity by Williams, Jacinta B, Mallorga, Pierre J, Lemaire, Wei, Williams, David L, Na, Sang, Patel, Smita, Conn, Jeffrey P, Pettibone, Douglas J, Austin, Christopher, Sur, Cyrille

“…Human placental choriocarcinoma (JAR) cells endogenously expressing glycine transporter type 1a (GlyT1a) have been cultured in 96-well scintillating…”
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Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys by Tigges, M, Iuvone, P M, Fernandes, A, Sugrue, M F, Mallorga, P J, Laties, A M, Stone, R A

“…To study a potential role for muscarinic receptors in the inhibition of deprivation-induced excessive axial elongation and myopia in a monkey model. The right…”
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New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides by Prugh, John D, Hartman, George D, Mallorga, Pierre J, McKeever, Brian M, Michelson, Stuart R, Murcko, Mark A, Schwam, Harvey, Smith, Robert L, Sondey, John M

“…A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive…”
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Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase by Scholz, Thomas H, Sondey, John M, Randall, William C, Schwam, Harvey, Thompson, Wayne J, Mallorga, Pierre J, Sugrue, Michael F, Graham, Samuel L

“…A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic…”
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3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors by Hunt, Cecilia A, Mallorga, Pierre J, Michelson, Stuart R, Schwam, Harvey, Sondey, John M, Smith, Robert L, Sugrue, Michael F, Shepard, Kenneth L

“…3-Aminoalkyl derivatives of thieno[2,3-b][1,4]thiazine-6-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. The compounds…”
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Corrigendum to “Development of a scintillation proximity assay for analysis of Na+/Cl− -dependent neurotransmitter transporter activity” [Anal. Biochem. 321 (2003) 31–37] by Williams, Jacinta B., Mallorga, Pierre J., Lemaire, Wei, Williams, David L., Na, Sang, Patel, Smita, Jeffrey Conn, P., Pettibone, Douglas J., Austin, Christopher, Sura, Cyrille

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4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre J, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic…”
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Diphenylhydantoin: Pre-And Postnatal Administration Alters Diazepam Binding in Developing Rat Cerebral Cortex by Gallager, Dorothy W., Mallorga, Pierre

“…Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats…”
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Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma by Baldwin, John J, Ponticello, Gerald S, Anderson, Paul S, Christy, Marcia E, Murcko, Mark A, Randall, William C, Schwam, Harvey, Sugrue, Michael F, Gautheron, Pierre

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Effects of Muscarinic Cholinergic Receptor Antagonists on Postnatal Eye Growth of Rhesus Monkeys by FERNANDES, ALCIDES, IUVONE, P MICHAEL, SUGRUE, MICHAEL F., MALLORGA, PIERRE J., LATIES, ALAN M., STONE, RICHARD A., TIGGES, MARGARETE

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[3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization by Gallager, DW, Mallorga, P, Oertel, W, Henneberry, R, Tallman, J

“…Two types of benzodiazepine binding sites for [3H]diazepam in mammalian central nervous tissue were identified using selective in vitro tissue culture and in…”
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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex…”
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Mepacrine Blocks β -Adrenergic Agonist-Induced Desensitization in Astrocytoma Cells by Mallorga, Pierre, Tallman, John F., Henneberry, Richard C., Hirata, Fusao, Strittmatter, Warren T., Axelrod, Julius

“…C6astrocytoma cells contain β -adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP…”
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Benzodiazepine and β -adrenergic receptor ligands independently stimulate phospholipid methylation by Strittmatter, Warren J, Hirata, Fusao, Axelrod, Julius, Mallorga, Pierre, Tallman, John F, Henneberry, Richard C

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Ontogenetic changes in GABA modulation of brain benzodiazepine binding by Mallorga, P, Hamburg, M, Tallman, J F, Gallager, D W

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