Search Results - "Mallo, Moises"
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Reassessing the Role of Hox Genes during Vertebrate Development and Evolution
Published in Trends in genetics (01-03-2018)“…Since their discovery Hox genes have been at the core of the established models explaining the development and evolution of the vertebrate body plan as well as…”
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Vertebrate Pattern Formation
Published 2024“…Vertebrate Pattern Formation, Volume 159 in the Current Topics in Developmental Biology series, highlights advances in the field, with this volume presenting…”
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The vertebrate tail: a gene playground for evolution
Published in Cellular and molecular life sciences : CMLS (01-03-2020)“…The tail of all vertebrates, regardless of size and anatomical detail, derive from a post-anal extension of the embryo known as the tail bud. Formation, growth…”
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Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny
Published in Essays in biochemistry (08-12-2022)“…The importance of Hox genes for the development and evolution of the vertebrate axial skeleton and paired appendages has been recognized for already several…”
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The regulation of Hox gene expression during animal development
Published in Development (Cambridge) (01-10-2013)“…Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific…”
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Revisiting the involvement of signaling gradients in somitogenesis
Published in The FEBS journal (01-04-2016)“…During embryonic development, formation of individual vertebrae requires that the paraxial mesoderm becomes divided into regular segmental units known as…”
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Of Necks, Trunks and Tails: Axial Skeletal Diversity among Vertebrates
Published in Diversity (Basel) (01-07-2021)“…The axial skeleton of all vertebrates is composed of individual units known as vertebrae. Each vertebra has individual anatomical attributes, yet they can be…”
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Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes
Published in Developmental cell (11-02-2019)“…During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory…”
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Deconstructing the molecular mechanisms shaping the vertebrate body plan
Published in Current opinion in cell biology (01-12-2018)“…The large display of body shapes and sizes observed among vertebrates ultimately represent variations of a common basic body plan. This likely results from the…”
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Evolving Locomotion with Hoxc9
Published in Developmental cell (28-04-2014)“…Limb innervation is established by opposing Hox-dependent activities. In this issue of Developmental Cell, Jung et al. (2014) show that Hoxc9 restriction of…”
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Regulatory changes associated with the head to trunk developmental transition
Published in BMC biology (08-08-2023)“…Development of vertebrate embryos is characterized by early formation of the anterior tissues followed by the sequential extension of the axis at their…”
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Epha1 is a cell-surface marker for the neuromesodermal competent population
Published in Development (Cambridge) (15-03-2022)“…The vertebrate body is built during embryonic development by the sequential addition of new tissue as the embryo grows at its caudal end. During this process,…”
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Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity
Published in Development (Cambridge) (01-02-2016)“…Formation of the vertebrate axial skeleton requires coordinated Hox gene activity. Hox group 6 genes are involved in the formation of the thoracic area owing…”
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Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle‐specific signatures in mouse embryos
Published in Developmental dynamics (01-10-2022)“…Background The turtle carapace is an evolutionary novelty resulting from changes in the processes that build ribs and their associated muscles in most tetrapod…”
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Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape
Published in Nature communications (20-03-2024)“…The hindlimb and external genitalia of present-day tetrapods are thought to derive from an ancestral common primordium that evolved to generate a wide…”
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Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos
Published in Developmental cell (10-06-2013)“…The vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different…”
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Controlling Hox gene expression and activity to build the vertebrate axial skeleton
Published in Developmental dynamics (01-01-2014)“…It has long been known that Hox genes are central players in patterning the vertebrate axial skeleton. Extensive genetic studies in the mouse have revealed…”
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CD5L as a promising biological therapeutic for treating sepsis
Published in Nature communications (15-05-2024)“…Sepsis results from systemic, dysregulated inflammatory responses to infection, culminating in multiple organ failure. Here, we demonstrate the utility of CD5L…”
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Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
Published in Developmental cell (08-08-2016)“…Vertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the evolutionary and developmental origins of this diversity remain…”
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A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
Published in eLife (29-06-2020)“…Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called…”
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