Search Results - "Mallia, Madhava B"

Molecular imaging of tumor hypoxia: Evolution of nitroimidazole radiopharmaceuticals and insights for future development by Mittal, Sweety, Mallia, Madhava B.

“…Though growing evidence has been collected in support of the concept of dose escalation based on the molecular level images indicating hypoxic tumor…”
Get full text

On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia by Mallia, Madhava B., Subramanian, Suresh, Mathur, Anupam, Sarma, H.D., Venkatesh, Meera, Banerjee, Sharmila

“…The presence and extent of hypoxic regions in cancerous tissue bears a negative influence on the effectiveness of radiation therapy and chemotherapy of the…”
Get full text

A thiourea‐bridged 99mTc(CO)3‐dipicolylamine‐2‐nitroimidazole complex for targeting tumor hypoxia: Utilizing metabolizable thiourea‐bridge to improve pharmacokinetics by Mittal, Sweety, Kumar, Chandan, Jha, Laxmi, Mallia, Madhava B.

“…The 2‐nitroimidazole based 99mTc‐radiopharmaceuticals are widely explored for imaging tumor hypoxia. Radiopharmaceuticals for targeting hypoxia are often…”
Get full text

A thiourea-bridged 99m Tc(CO) 3 -dipicolylamine-2-nitroimidazole complex for targeting tumor hypoxia: Utilizing metabolizable thiourea-bridge to improve pharmacokinetics by Mittal, Sweety, Kumar, Chandan, Jha, Laxmi, Mallia, Madhava B

“…The 2-nitroimidazole based Tc-radiopharmaceuticals are widely explored for imaging tumor hypoxia. Radiopharmaceuticals for targeting hypoxia are often…”
Get full text

Technetium-99m labeled core shell hyaluronate nanoparticles as tumor responsive, metastatic skeletal lesion targeted combinatorial theranostics by Kaur, Shahdeep, Balakrishnan, Biji, Mallia, Madhava B., Keshari, Roshan, Hassan, P.A., Banerjee, Rinti

“…Achieving target specific delivery of chemotherapeutics in metastatic skeletal lesions remains a major challenge. Towards this, a dual drug loaded,…”
Get full text

Multifunctional Core–Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy by Balakrishnan, Biji, Subramanian, Suresh, Mallia, Madhava B, Repaka, Krishnamohan, Kaur, Shahdeep, Chandan, Rajeet, Bhardwaj, Prateek, Dash, Ashutosh, Banerjee, Rinti

“…Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core–shell…”
Get full text

68Ga-labeled PET tracers for targeting tumor hypoxia: Role of bifunctional chelators on pharmacokinetics by Mittal, Sweety, Sharma, Rohit, Mallia, Madhava B., Sarma, Haladhar Dev

“…By virtue of their oxygen dependant accumulation in hypoxic cells, radiolabeled nitroimidazole analogues have been widely used for detecting tumor hypoxia…”
Get full text

Preparation of Rhenium-188-Lipiodol Using Freeze-Dried Kits for Transarterial Radioembolization: An Overview and Experience in a Hospital Radiopharmacy by Radhakrishnan, Edathurutykalarickal Ramakurup, Chirayil, Viju, Pandiyan, Arun, Subramanian, Suresh, Mallia, Madhava B, Kamaleshwaran, Koramadai Karuppusamy, Shinto, Ajit

“…Rhenium-188( Re)-lipiodol is a clinically effective, economically viable radiopharmaceutical for Selective Internal Radiation Therapy of liver cancer. Present…”
Get more information

Cancer Care Using an Array of Radiolabelled Small Molecules by Mallia, Madhava B., Pillai, Maroor Raghavan Ambikalamajan

Get full text

Improved freeze-dried kit for the preparation of 188ReN-DEDC/lipiodol for the therapy of unresectable hepatocellular carcinoma by Mallia, Madhava B., Chirayil, Viju, Dash, Ashutosh

“…Rhenium-188-N-(DEDC)2/lipiodol (abbreviated as 188ReN-DEDC, where DEDC = monoanionic diethyldithiocarbamate) is a clinically proven radiopharmaceutical for the…”
Get full text

Improved freeze-dried kit for the preparation of 188 ReN-DEDC/lipiodol for the therapy of unresectable hepatocellular carcinoma by Mallia, Madhava B, Chirayil, Viju, Dash, Ashutosh

“…Rhenium-188-N-(DEDC) /lipiodol (abbreviated as ReN-DEDC, where DEDC = monoanionic diethyldithiocarbamate) is a clinically proven radiopharmaceutical for the…”
Get full text

Re-engineered theranostic gold nanoparticles for targeting tumor hypoxia by Mittal, Sweety, Kumar, Chandan, Mallia, Madhava B, Sarma, Haladhar Dev

“…Developing nanovehicles for selective delivery of a radiation dose/drug to hypoxic tumors is a present-day clinical requirement for effective treatment of…”
Get full text

Modulation of in vivo distribution through chelator: Synthesis and evaluation of a 2-nitroimidazole-dipicolylamine-(99m)Tc(CO)3 complex for detecting tumor hypoxia by Mallia, Madhava B, Mittal, Sweety, Sarma, Haladhar D, Banerjee, Sharmila

“…Previous studies have clearly demonstrated strong correlation between in vivo distribution and blood clearance of radiopharmaceuticals for the detection of…”
Get full text

Hypoxia targeting lutetium-177-labeled nitroimidazole-decorated gold particles as cancer theranostic nanoplatforms by Mittal, Sweety, Sharma, Rohit, Sarma, H. D, Mallia, Madhava B

“…Considering the role of hypoxia in cancer progression and poor prognosis, hypoxia-centric theranostic approaches may have immense potential in clinical cancer…”
Get full text

188 Re-N-DEDC Lipiodol for Treatment of Hepatocellular Carcinoma (HCC)-A Clinical and Prospective Study to Assess In-Vivo Distribution in Patients and Clinical Feasibility of Therapy by Kumar, Naresh, Gupta, Priyanka, Shamim, Shamim Ahmed, Chirayil, Viju, Subramanian, Suresh, Mallia, Madhava B, Bal, Chandrasekhar

“…The incidence of inoperable hepatocellular carcinoma (HCC) with/without malignant portal vein thrombosis (PVT) is increasing in India for the last decade;…”
Get full text

Clinical Management of Liver Cancer in India and Other Developing Nations: A Focus on Radiation Based Strategies by Subramanian, Suresh, Mallia, Madhava B., Shinto, Ajit S., Mathew, Ashwathy S.

“…Hepatocellular carcinoma (HCC) is a global killer with preponderance in Asian and African countries. It poses a challenge for successful management in less…”
Get full text

Synthesis and biodistribution studies of 99m Tc labeled fatty acid derivatives prepared via "Click approach" for potential use in cardiac imaging by Das, Soumen, Mathur, Anupam, Sakhare, Navin, Mallia, Madhava B, Sarma, Haladhar Dev, Sachdev, Satbir Singh, Dash, Ashutosh

“…I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to…”
Get full text

Synthesis and evaluation of 99mTc-analogues of [123/131I]mIBG prepared via [99mTc][Tc(CO)3(H2O)3]+ synthon for targeting norepinephrine transporter by Das, Soumen, Sakhare, Navin, Mathur, Anupam, Mallia, Madhava B., Mirapurkar, Shubhangi, Sheela, M., Sarma, H.D., Sachdev, S.S., Dash, Ashutosh

“…meta-[123/131I]Iodobenzylguanidine (mIBG) is a clinical agent used for imaging neuroendocrine tumors, where uptake in tumor is via active transport mechanism…”
Get full text

A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia by Mallia, Madhava B, Mathur, Anupam, Sarma, Haladhar D, Banerjee, Sharmila

“…The PET radiopharmaceutical [(18)F]Fluromisonidazole ([(18)F]FMISO) is presently the agent of choice for the clinical imaging of tumor hypoxia. Considering the…”
Get more information

A Freeze-Dried Kit for the Preparation of (188)Re-HEDP for Bone Pain Palliation: Preparation and Preliminary Clinical Evaluation by Mallia, Madhava B, Shinto, Ajit Sugunan, Kameswaran, Mythili, Kamaleshwaran, Koramadai Karuppusamy, Kalarikal, Radhakrishnan, Aswathy, K K, Banerjee, Sharmila

“…(188)Re-HEDP is an established radiopharmaceutical used for pain palliation in patients with osseous metastasis. Considering commercial availability of…”
Get more information