Search Results - "Malley, Mary F."

Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators by Xiao, Hai-Yun, Wu, Dauh-Rurng, Malley, Mary F, Gougoutas, Jack Z, Habte, Sium F, Cunningham, Mark D, Somerville, John E, Dodd, John H, Barrish, Joel C, Nadler, Steven G, Dhar, T. G. Murali

“…The first stereoselective synthesis of the hexahydroimidazo[1,5b]isoquinoline (HHII) scaffold as a surrogate for the steroidal A-B ring system is described…”
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold by Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor…”
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Synthesis, characterization, and crystal structures of M(DO3A) (M = iron, gadolinium) and Na[M(DOTA)] (M = Fe, yttrium, Gd) by Chang, C. Allen, Francesconi, Lynn C, Malley, Mary F, Kumar, Krishan, Gougoutas, Jack Z, Tweedle, Michael F, Lee, Daniel W, Wilson, Lon J

“…Macrocyclic amino carboxylate (DOTA and DO3A, where DOTA is 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane and DO3A is…”
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Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2 by Yang, Michael G, Xiao, Zili, Zhao, Rulin, Tebben, Andrew J, Wang, Bei, Cherney, Robert J, Batt, Douglas G, Brown, Gregory D, Cvijic, Mary Ellen, Duncia, John V, Gallela, Michael A, Gardner, Daniel S, Khandelwal, Purnima, Malley, Mary F, Pang, Jian, Rose, Anne V, Santella, Joseph B, Sarjeant, Amy A, Xu, Songmei, Mathur, Arvind, Mandlekar, Sandhya, Vuppugalla, Ragini, Zhao, Qihong, Carter, Percy H

“…To improve the metabolic stability profile of BMS-741672 (1a), we undertook a structure–activity relationship study in our trisubstituted cyclohexylamine…”
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Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents by Rovnyak, George C, Atwal, Karnail S, Hedberg, Anders, Kimball, S. David, Moreland, Suzanne, Gougoutas, Jack Z, O'Reilly, Brian C, Schwartz, Joseph, Malley, Mary F

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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672 by Yang, Michael G, Xiao, Zili, Cherney, Robert J, Tebben, Andrew J, Batt, Douglas G, Brown, Gregory D, Chen, Jing, Cvijic, Mary Ellen, Dabros, Marta, Duncia, John V, Galella, Michael, Gardner, Daniel S, Khandelwal, Purnima, Ko, Soo S, Malley, Mary F, Mo, Ruowei, Pang, Jian, Rose, Anne V, Santella, Joseph B, Shi, Hong, Srivastava, Anurag, Traeger, Sarah C, Wang, Bei, Xu, Songmei, Zhao, Rulin, Barrish, Joel C, Mandlekar, Sandhya, Zhao, Qihong, Carter, Percy H

“…We encountered a dilemma in the course of studying a series of antagonists of the G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with…”
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Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists by Sheppeck, James E., Gilmore, John L., Xiao, Hai-Yun, Dhar, T.G. Murali, Nirschl, David, Doweyko, Arthur M., Sack, Jack S., Corbett, Martin J., Malley, Mary F., Gougoutas, Jack Z., Mckay, Lorraine, Cunningham, Mark D., Habte, Sium F., Dodd, John H., Nadler, Steven G., Somerville, John E., Barrish, Joel C.

“…Modification of a phenolic lead structure based on lessons learned from increasing the potency of steroidal glucocorticoid agonists lead to the discovery of…”
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Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines by Atwal, Karnail S, Rovnyak, George C, Schwartz, Joseph, Moreland, Suzanne, Hedberg, Anders, Gougoutas, Jack Z, Malley, Mary F, Floyd, David M

“…2-Heterosubstituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecar box ylic acid esters 8, which lack the potential CS symmetry of dihydropyridine calcium channel…”
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Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors by Lin, Shuqun, Wrobleski, Stephen T., Hynes, John, Pitt, Sidney, Zhang, Rosemary, Fan, Yi, Doweyko, Arthur M., Kish, Kevin F., Sack, John S., Malley, Mary F., Kiefer, Susan E., Newitt, John A., McKinnon, Murray, Trzaskos, James, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

“…An intramolecular nitrogen–sulfur nonbonding interaction has been used in the design of a novel series of 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase…”
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Characterization of NADP + binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes by Constantine, Keith L, Mueller, Luciano, Goldfarb, Valentina, Wittekind, Michael, Metzler, William J, Yanchunas, Joseph, Robertson, James G, Malley, Mary F, Friedrichs, Mark S, Farmer, Bennett T

“…Backbone-atom resonances have been assigned for both the substrate-free and the NADP +-complexed forms of UDP- N-acetylenolpyruvylglucosamine reductase (MurB),…”
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Studies towards understanding the mechanism of the unusual rearrangement of certain 5-propargyloxyindoles by Macor, John E, Langer, Oren D, Gougoutas, Jack Z, Malley, Mary F, Cornelius, Lyndon A.M

“…A mechanism of the rearrangement of 5-propargyloxyindoles is proposed and supported by the formation of a novel tetracyclic indole derivative 12 as the major…”
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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability:  Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors by Magnin, David R, Robl, Jeffrey A, Sulsky, Richard B, Augeri, David J, Huang, Yanting, Simpkins, Ligaya M, Taunk, Prakash C, Betebenner, David A, Robertson, James G, Abboa-Offei, Benoni E, Wang, Aiying, Cap, Michael, Xin, Li, Tao, Li, Sitkoff, Doree F, Malley, Mary F, Gougoutas, Jack Z, Khanna, Ashish, Huang, Qi, Han, Song-Ping, Parker, Rex A, Hamann, Lawrence G

“…A series of methanoprolinenitrile-containing dipeptide mimetics were synthesized and assayed as inhibitors of the N-terminal sequence-specific serine protease…”
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Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT2C Receptor by Wacker, Dean A, Varnes, Jeffrey G, Malmstrom, Sarah E, Cao, Xueying, Hung, Chen-Pin, Ung, Thao, Wu, Ginger, Zhang, Ge, Zuvich, Eva, Thomas, Michael A, Keim, William J, Cullen, Mary Jane, Rohrbach, Kenneth W, Qu, Qinling, Narayanan, Rangaraj, Rossi, Karen, Janovitz, Evan, Lehman-McKeeman, Lois, Malley, Mary F, Devenny, James, Pelleymounter, Mary Ann, Miller, Keith J, Robl, Jeffrey A

“…Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the…”
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Cannabinoid CB1 receptor ligand binding and function examined through mutagenesis studies of F200 and S383 by Sitkoff, Doree F., Lee, Ning, Ellsworth, Bruce A., Huang, Qi, Kang, Liya, Baska, RoseAnn, Huang, Yanting, Sun, Chongqing, Pendri, Annapurna, Malley, Mary F., Scaringe, Raymond P., Gougoutas, Jack Z., Reggio, Patricia H., Ewing, William R., Pelleymounter, Mary Ann, Carlson, Kenneth E.

“…The cannabinoid CB1 G protein-coupled receptor has been shown to be a regulator of food consumption and has been studied extensively as a drug target for the…”
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Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer by Dhar, T.G. Murali, Yang, Guchen, Davies, Paul, Malley, Mary F., Gougoutas, Jack Z., Wu, Dauh-Rurng, Barrish, Joel C., Carter, Percy H.

“…Conformational restriction of open chain analogs with a more polar tetrahydro-1,3-oxazin-2-one spacer led to the identification of potent urea-based CCR3…”
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Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs by Bisacchi, Gregory S, Braitman, Abbe, Cianci, Christopher W, Clark, Junius M, Field, A. Kirk, Hagen, Moira E, Hockstein, Deborah R, Malley, Mary F, Mitt, Toomas

“…The syntheses of the enantiomeric cyclobutyl guanine nucleoside analogues [1R-1 alpha, 2 beta, 3 alpha]- and [1S-1 alpha, 2 beta, 3 alpha]-2-…”
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Novel 1,4-Homofragmentation via an α-Lactone by Godfrey, Jollie D, Fox, Rita T, Buono, Frederic G, Gougoutas, Jack Z, Malley, Mary F

“…Conversion of an α,α-dichloroester to the corresponding α-keto acid was unexpectedly complicated by a novel 1,4-homofragmentation. Investigation of the…”
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Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters by ATWAL, K. S, O'REILLY, B. C, GOUGOUTAS, J. Z, MALLEY, M. F

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Practical synthesis of an enantiomerically pure synthon for the preparation of mevinic acid analogs by Karanewsky, Donald S, Malley, Mary F, Gougoutas, Jack Z

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Neutral, seven-coordinate dioxime complexes of technetium(III): synthesis and characterization by Linder, Karen E, Malley, Mary F, Gougoutas, Jack Z, Unger, Steve E, Nunn, Adrian D

“…The tin-capped complexes {sup 99}Tc(oxime){sub 3}({mu}-OH)SnCl{sub 3} (oxime = dimethylglyoxime (DMG) or cyclohexanedione dioxime (CDO)) can be prepared by the…”
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