Search Results - "Malley, Deborah S."

A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts by Malley, Deborah S., Hamoudi, Rifat A., Kocialkowski, Sylvia, Pearson, Danita M., Collins, Vincent Peter, Ichimura, Koichi

“…O 6 -Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes alkyl DNA adducts such as those induced by alkylating agents. Loss of MGMT…”
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MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations by Mulholland, Shani, Pearson, Danita M., Hamoudi, Rifat A., Malley, Deborah S., Smith, Caroline M., Weaver, Jamie M.J., Jones, David T.W., Kocialkowski, Sylvia, Bäcklund, L. Magnus, Collins, V. Peter, Ichimura, Koichi

“…We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta…”
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Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts by Jones, David T. W., Mulholland, Shani A., Pearson, Danita M., Malley, Deborah S., Openshaw, Samuel W. S., Lambert, Sally R., Liu, Lu, Bäcklund, L. Magnus, Ichimura, Koichi, Collins, V. Peter

“…Diffuse astrocytomas (WHO grade II) typically present as slow-growing tumours showing significant cellular differentiation, but possessing a tendency towards…”
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Abstract 2794: Mutation of IDH1/2 is strongly associated with MGMT methylation in adult astrocytic and oligodendroglial tumors by Mulholland, Shani A., Malley, Deborah S., Hamoudi, Rifat, Kocialkowski, Sylvia, Pearson, Danita, Collins, V.Peter, Ichimura, Koichi

“…Abstract Background: Astrocytic, oligodendroglial and oligoastrocytic tumors are major subtypes of human gliomas, which are the most common malignant primary…”
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Abstract LB-181: Genome-wide DNA methylation analysis reveals novel hypermethylated genes in astrocytic tumors by Mulholland, Shani A., Hamoudi, Rifat A., Malley, Deborah S., Collins, V. Peter, Ichimura, Koichi

“…Abstract Introduction: Astrocytomas are the most common subtype of glioma, accounting for about 70% of all malignant tumors found in the central nervous…”
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