Search Results - "Mallet, Robert T"

Molecular Mechanisms of High-Altitude Acclimatization by Mallet, Robert T, Burtscher, Johannes, Pialoux, Vincent, Pasha, Qadar, Ahmad, Yasmin, Millet, Grégoire P, Burtscher, Martin

“…High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous molecular mechanisms affect appropriate acclimatization to…”
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Impact of High Altitude on Cardiovascular Health: Current Perspectives by Mallet, Robert T, Burtscher, Johannes, Richalet, Jean-Paul, Millet, Gregoire P, Burtscher, Martin

“…Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more than 100 million lowlanders visit mountainous areas above 2500 m…”
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Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential by Mallet, Robert T, Manukhina, Eugenia B, Ruelas, Steven Shea, Caffrey, James L, Downey, H Fred

“…The calibrated application of limited-duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress…”
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Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease by Manukhina, Eugenia B, Downey, H Fred, Shi, Xiangrong, Mallet, Robert T

“…Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity,…”
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Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application by Mallet, Robert T, Olivencia-Yurvati, Albert H, Bünger, Rolf

“…Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium’s high demand for oxygen and energy substrates leaves it acutely…”
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Editorial: Climate Change in Mountainous Areas and Related Health Effects by Mallet, Robert T., Burtscher, Martin, Cogo, Annalisa

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Pyruvate Protects the Brain Against Ischemia-Reperfusion Injury by Activating the Erythropoietin Signaling Pathway by RYOU, Myoung-Gwi, RAN LIU, MING REN, JIE SUN, MALLET, Robert T, YANG, Shao-Hua

“…Pyruvate is known to be cytoprotective through antioxidant and anti-inflammatory mechanisms. We tested the hypothesis that pyruvate protects the brain against…”
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Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study by Wang, Hong, Shi, Xiangrong, Schenck, Hannah, Hall, James R., Ross, Sarah E., Kline, Geoffrey P., Chen, Shande, Mallet, Robert T., Chen, Peijie

“…Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown…”
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Erythropoietin: powerful protection of ischemic and post-ischemic brain by Nguyen, Anh Q, Cherry, Brandon H, Scott, Gary F, Ryou, Myoung-Gwi, Mallet, Robert T

“…Ischemic brain injury inflicted by stroke and cardiac arrest ranks among the leading causes of death and long-term disability in the United States. The brain…”
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Enhanced cerebral perfusion during brief exposures to cyclic intermittent hypoxemia by Liu, Xiaoli, Xu, Diqun, Hall, James R, Ross, Sarah, Chen, Shande, Liu, Howe, Mallet, Robert T, Shi, Xiangrong

“…Cerebral vasodilation and increased cerebral oxygen extraction help maintain cerebral oxygen uptake in the face of hypoxemia. This study examined…”
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Hypoxic breathing produces more intense hypoxemia in elderly women than in elderly men by Zhao, Jinfeng, Ding, Yanfeng, Kline, Geoffrey P, Zhou, Zhengyang, Mallet, Robert T, Shi, Xiangrong

“…Brief hypoxic exposures are increasingly applied as interventions for aging-related conditions. To optimize the therapeutic impact of hypoxia, knowledge of the…”
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Intermittent Hypoxia Training Prevents Deficient Learning-Memory Behavior in Mice Modeling Alzheimer's Disease: A Pilot Study by Ryou, Myoung-Gwi, Chen, Xiaoan, Cai, Ming, Wang, Hong, Jung, Marianna E, Metzger, Daniel B, Mallet, Robert T, Shi, Xiangrong

“…In mouse models of Alzheimer's disease (AD), normobaric intermittent hypoxia training (IHT) can preserve neurobehavioral function when applied before deficits…”
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Intermittent hypoxia: cause of or therapy for systemic hypertension? by Serebrovskaya, Tatiana V, Manukhina, Eugenia B, Smith, Michael L, Downey, H Fred, Mallet, Robert T

“…During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases heart rate, cardiac output, peripheral resistance and systemic arterial…”
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Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells by Wang, Xiaofei, Perez, Evelyn, Liu, Ran, Yan, Liang-Jun, Mallet, Robert T, Yang, Shao-Hua

“…Abstract Oxidative stress is implicated in neurodegenerative diseases including stroke, Alzheimer's disease and Parkinson's disease, and has been extensively…”
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Hypoxia and brain aging: Neurodegeneration or neuroprotection? by Burtscher, Johannes, Mallet, Robert T., Burtscher, Martin, Millet, Grégoire P.

“…•Hypoxia is a central factor in brain aging and the development of age-related neurological diseases.•Severe hypoxia is detrimental to the brain and is…”
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Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia by Manukhina, Eugenia B, Downey, H Fred, Mallet, Robert T

“…Hypoxia is one of the most frequently encountered stresses in health and disease. The duration, frequency, and severity of hypoxic episodes are critical…”
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Adaptive Responses to Hypoxia and/or Hyperoxia in Humans by Burtscher, Johannes, Mallet, Robert T, Pialoux, Vincent, Millet, Grégoire P, Burtscher, Martin

“…Oxygen is indispensable for aerobic life, but its utilization exposes cells and tissues to oxidative stress; thus, tight regulation of cellular, tissue, and…”
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Metabolic cardioprotection by pyruvate: recent progress by Mallet, Robert T, Sun, Jie, Knott, E Marty, Sharma, Arti B, Olivencia-Yurvati, Albert H

“…Pyruvate, a natural metabolic fuel and antioxidant in myocardium and other tissues, exerts a variety of cardioprotective actions when provided at…”
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Store-operated Ca2+ channel signaling: Novel mechanism for podocyte injury in kidney disease by Tao, Yu, Mallet, Robert T, Mathis, Keisa W, Ma, Rong

“…Studies over the last decade have markedly broadened our understanding of store-operated Ca2+ channels (SOCs) and their roles in kidney diseases and podocyte…”
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Ischaemic and hypoxic conditioning: potential for protection of vital organs by Sprick, Justin D., Mallet, Robert T., Przyklenk, Karin, Rickards, Caroline A.

“…New Findings What is the topic of this review? Remote ischaemic preconditioning (RIPC) and hypoxic preconditioning as novel therapeutic approaches for cardiac…”
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