Search Results - "Mallampalli, R K"

Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis by Chen, B B, Glasser, J R, Coon, T A, Mallampalli, R K

“…Aurora B kinase is an integral regulator of cytokinesis, as it stabilizes the intercellular canal within the midbody to ensure proper chromosomal segregation…”
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F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 by Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, B B, Mallampalli, R K

“…Fbxl7, a subunit of the SCF (Skp-Cul1-F-box protein) complex induces mitotic arrest in cells; however, molecular factors that control its cellular abundance…”
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NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy by Kagan, V E, Jiang, J, Huang, Z, Tyurina, Y Y, Desbourdes, C, Cottet-Rousselle, C, Dar, H H, Verma, M, Tyurin, V A, Kapralov, A A, Cheikhi, A, Mao, G, Stolz, D, St. Croix, C M, Watkins, S, Shen, Z, Li, Y, Greenberg, M L, Tokarska-Schlattner, M, Boissan, M, Lacombe, M-L, Epand, R M, Chu, C T, Mallampalli, R K, Bayır, H, Schlattner, U

“…Mitophagy is critical for cell homeostasis. Externalization of the inner mitochondrial membrane phospholipid, cardiolipin (CL), to the surface of the outer…”
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Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury by ZHOU, J, WU, Y, HENDERSON, F, MCCOY, D. M, SALOME, R. G, MCGOWAN, S. E, MALLAMPALLI, R. K

“…Surfactant deficiency is an important contributor to the acute respiratory distress syndrome, a disorder that commonly occurs after bacterial sepsis…”
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STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia by Poe, S L, Arora, M, Oriss, T B, Yarlagadda, M, Isse, K, Khare, A, Levy, D E, Lee, J S, Mallampalli, R K, Chan, Y R, Ray, A, Ray, P

“…Bacterial pneumonia remains a significant burden worldwide. Although an inflammatory response in the lung is required to fight the causative agent, persistent…”
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Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection by Zhao, Y, Olonisakin, T F, Xiong, Z, Hulver, M, Sayeed, S, Yu, M T, Gregory, A D, Kochman, E J, Chen, B B, Mallampalli, R K, Sun, M, Silverstein, R L, Stolz, D B, Shapiro, S D, Ray, A, Ray, P, Lee, J S

“…Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promote tissue…”
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Ceramide Regulates Lipopolysaccharide-Induced Phosphatidylinositol 3-Kinase and Akt Activity in Human Alveolar Macrophages by Monick, Martha M, Mallampalli, Rama K, Carter, Aaron B, Flaherty, Dawn M, McCoy, Diann, Robeff, Pamela K, Peterson, Michael W, Hunninghake, Gary W

“…The phosphatidylinositol (PI) 3-kinase pathway is an important regulator of cell survival. In human alveolar macrophages, we found that LPS activates PI…”
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F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest by Chen, B B, Glasser, J R, Coon, T A, Mallampalli, R K

“…Dysregulated behavior of cell cycle proteins and their control by ubiquitin E3 ligases is an emerging theme in human lung cancer. Here, we identified and…”
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Effects of intratracheal instillation of TNF-alpha on surfactant metabolism by Salome, Ronald G, McCoy, Diann M, Ryan, Alan J, Mallampalli, Rama K

“…Department of Internal Medicine and the Department of Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, Iowa 52242 Tumor…”
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Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids by Mallampalli, R K, Salome, R G, Spector, A A

“…Disaturated phosphatidylcholine (DSPC) is the most distinctive surface-active lipid in pulmonary surfactant. The feeding of docosahexanoic acid (DHA) 22:6 n-3…”
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Lipoprotein deprivation stimulates transcription of the CTP:phosphocholine cytidylyltransferase gene by Ryan, A J, McCoy, D M, Mathur, S N, Field, F J, Mallampalli, R K

“…We examined the effect of lipoprotein deprivation on the expression of the rate-regulatory enzyme involved in phosphatidylcholine (PtdCho) synthesis,…”
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Oxygen modulates surfactant protein mRNA expression and phospholipid production in human fetal lung in vitro by Acarregui, M J, Brown, J J, Mallampalli, R K

“…We studied the effect of 20-95% O2 on mRNA levels for the surfactant-associated proteins (SP)-A, SP-B, and SP-C and [3H]choline incorporation into total…”
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Identification of sex-specific differences in surfactant synthesis in rat lung by MCCOY, D. M, SALOME, R. G, KUSNER, D. J, IYAR, S. S, MALLAMPALLI, R. K

“…Delayed lung maturation and lower levels of surfactant phosphatidylcholine have been previously identified in male fetuses compared with female fetuses in…”
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Lung CTP:choline-phosphate cytidylyltransferase: activation of cytosolic species by unsaturated fatty acid by Mallampalli, R K, Salome, R G, Hunninghake, G W

“…CTP:choline-phosphate cytidylyltransferase is the principal rate-limiting enzyme required for surfactant phosphatidylcholine synthesis. We examined the in…”
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Tumor Necrosis Factor-α Inhibits Expression of CTP:Phosphocholine Cytidylyltransferase by Mallampalli, Rama K., Ryan, Alan J., Salome, Ronald G., Jackowski, Suzanne

“…We investigated the effects of tumor necrosis factor α (TNFα), a key cytokine involved in inflammatory lung disease, on phosphatidylcholine (PtdCho)…”
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Isolation and Immortalization of Rat Pre-Type II Cell Lines by Rama K. Mallampalli, Connie S. Floerchinger, Hunninghake, Gary W.

“…The fetal respiratory distress syndrome is due, in part, to the presence of abundant pre-type II alveolar epithelial cells that have not yet differentiated…”
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Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein by Sinn, Patrick L, Penisten, Andrea K, Burnight, Erin R, Hickey, Melissa A, Williams, Greg, McCoy, Diann M, Mallampalli, Rama K, McCray, Paul B

“…A feline immunodeficiency virus (FIV)-based lentiviral vector was pseudotyped to identify envelope (env) glycoproteins that direct efficient gene transfer to…”
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Betamethasone activation of CTP:cholinephosphate cytidylyltransferase in vivo is lipid dependent by Mallampalli, R K, Walter, M E, Peterson, M W, Hunninghake, G W

“…Glucocorticoids increase surfactant phosphatidylcholine synthesis, in part, by stimulating the rate regulatory enzyme CTP:cholinephosphate…”
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Expression of Plasma Phospholipid Transfer Protein mRNA in Normal and Emphysematous Lungs and Regulation by Hypoxia by Jiang, X C, D'Armiento, J, Mallampalli, R K, Mar, J, Yan, S F, Lin, M

“…The lung is the major site expressing plasma phospholipid transfer protein (PLTP) mRNA in humans and mice, suggesting that this protein might have an important…”
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A34 ARDS AND LUNG INJURY: Inhibition Of Nalp7 Inflammasome Activity With A Novel Small Molecule Antagonist Of The Deubiquitinase Stambp by Bednash, J S, Weathington, N, t, R, Mckelvey, A, Chen, B B, Mallampalli, R K

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