Search Results - "Malkova, Natalia V"
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Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
Published in Brain, behavior, and immunity (01-05-2012)“…Highlight ► We find that activation of the maternal immune system yields offspring with cardinal symptoms of autism: highly repetitive behavior and deficits in…”
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Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia
Published in Proceedings of the National Academy of Sciences - PNAS (17-06-2014)“…Maternal infection during pregnancy increases the risk for schizophrenia in offspring. In rodent models, maternal immune activation (MIA) yields offspring with…”
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An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
Published in Oncoimmunology (01-01-2021)“…Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several…”
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Reverse Transcriptase and Endonuclease Activities Encoded by Penelope-Like Retroelements
Published in Proceedings of the National Academy of Sciences - PNAS (12-10-2004)“…Penelope-like elements are a class of retroelement that have now been identified in >50 species belonging to at least 10 animal phyla. The Penelope element…”
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1056 XTX301, a tumor activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundInterleukin-12 (IL-12) is a proinflammatory cytokine that bridges innate and adaptive immunity by stimulating the differentiation of T helper 1 cells…”
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Synthetic peptide SLTCLVKGFY competes with β-endorphin for naloxone-insensitive binding sites on rat brain membranes
Published in Peptides (New York, N.Y. : 1980) (01-06-2002)“…The synthetic decapeptide Ser–Leu–Thr–Cys–Leu–Val–Lys–Gly–Phe–Tyr (termed immunorphin) corresponding to the sequence 364–373 of the CH3 domain of human…”
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β-Endorphin-like peptide SLTCLVKGFY reduces the production of 11-oxycorticosteroids by rat adrenal cortex through nonopioid β-endorphin receptors
Published in Peptides (New York, N.Y. : 1980) (01-12-2003)“…β-Endorphin-like peptide immunorphin (SLTCLVKGFY), a selective agonist of nonopioid β-endorphin receptor, was labeled with tritium to specific activity of 24…”
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Abstract 4451: Combination of local mRNA immunotherapy with systemic immune checkpoint blockade demonstrates anti-tumor activity across a diverse range of preclinical syngeneic tumor models
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Cancer immunotherapies with anti-PD-1/PD-L1 checkpoint blockade antibodies have revolutionized the treatment of a wide variety of malignancies…”
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The Stimulating Effect of the beta-Endorphin-Like Peptide Immunorphin on the Human T-Lymphoblastoid Cell Line Jurkat Is Mediated by a Non-Opioid Receptor for beta-Endorphin
Published in Russian journal of immunology : RJI : official journal of Russian Society of Immunology (01-04-2003)“…It was shown that beta-endorphin and the synthetic decapeptide SLTCLVKGFY that corresponds to the amino acid sequence 364-373 of the human IgG heavy chain…”
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Reverse transcriptase and endonuclease activities encoded by Penolope-like retrelements
Published in Proceedings of the National Academy of Sciences - PNAS (12-10-2004)“…Penelope-like elements are a class of retroelement that have now been identified in >50 species belonging to at least 10 animal phyla. The Penelope element…”
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Synthetic β-endorphin-like peptide immunorphin binds to non-opioid receptors for β-endorphin on T lymphocytes
Published in Peptides (New York, N.Y. : 1980) (01-12-2001)“…The synthetic decapeptide H-SLTCLVKGFY-OH (termed immunorphin) corresponding to the sequence 364–373 of the CH3 domain of human immunoglobulin G heavy chain…”
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