Search Results - "Maliwal, Deepika"

Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors by Gomha, Sobhi M., Zaki, Magdi E.A., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Ibrahim, Mohamed S., Fathalla, Maher, Hussein, Ahmed M.

“…The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer drug development due to its pivotal role in regulating the cell…”
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Comprehensive computational study in the identification of novel potential cholesterol lowering agents targeting proprotein convertase subtilisin/kexin type 9 by Maliwal, Deepika, Pissurlenkar, Raghuvir R. S., Telvekar, Vikas

“…The enzymatic target proprotein convertase subtilisin/kexin type 9 (PCSK9) is critically involved in the regulation of the lipoprotein metabolism leading to…”
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Identification of novel potential anti-diabetic candidates targeting human pancreatic [alpha]-amylase and human [alpha]-glycosidase: an exhaustive structure-based screening by Maliwal, Deepika, Pissurlenkar, Raghuvir R.S, Telvekar, Vikas

“…Diabetes is a major health issue that has reached alarming levels, affecting nearly half a billion people worldwide. It is a serious and long-term medical…”
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Synthesis, biological screening and in silico studies of new N-phenyl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine derivatives as potential antifungal and antitubercular agents by Nandurkar, Yogesh, Bhoye, Manish R., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Chavan, Abhijit, Katade, Sushma, Mhaske, Pravin C.

“…A new series of N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine, (8a-x) have been synthesized by a cyclo-condensation reaction of…”
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Identification of novel potential anti-diabetic candidates targeting human pancreatic α-amylase and human α-glycosidase: an exhaustive structure-based screening by Maliwal, Deepika, Pissurlenkar, Raghuvir R.S, Telvekar, Vikas

“…Diabetes is a major health issue that has reached alarming levels, affecting nearly half a billion people worldwide. It is a serious and long-term medical…”
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Synthesis, antidiabetic activity and in silico studies of benzo[b]thiophene based small molecule α-amylase inhibitors by Joshi, Rupal J., Dholariya, Monil P., Chothani, Savankumar R., Chamakiya, Chirag A., Varu, Hardik L., Karmur, Manisha B., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Bapodra, Atul H., Patel, Anilkumar S., Kapuriya, Naval P.

“…•Benzo[b]thiophene based small molecule α-amylase inhibitors.•Significant antidiabetic activity with IC50 ranging from 5.37 to 29.89 μM.•Compound 3b more…”
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Solvent-free synthesis, biological evaluation and in silico studies of novel 2-amino-7-(bis(2-hydroxyethyl)amino)-4H-chromene-3-carbonitrile derivatives as potential a-amylase inhibitors by Chothani, Savankumar R., Dholariya, Monil P., Joshi, Rupal J., Chamakiya, Chirag A., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Patel, Anilkumar S., Bhalodia, Jasmin J., Ambasana, Mrunal A., Patel, Rashmiben B., Bapodra, Atul H., Kapuriya, Naval P.

“…•Solvent free multicomponent protocol for novel 2-amino-4H-chromene derivatives.•Structure determination by IR, mass, 1H & 13C NMR spectroscopy and elemental…”
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New thiazolyl-isoxazole derivatives as potential anti-infective agents: design, synthesis, in vitro and in silico antimicrobial efficacy by Bhoye, Manish R, Shinde, Abhijit, Shaikh, Abdul Latif N, Shisode, Vilas, Chavan, Abhijit, Maliwal, Deepika, Pissurlenkar, Raghuvir R S, Mhaske, Pravin C

“…Antimicrobial resistance threatens the efficacious prevention and treatment of infectious diseases caused by microorganisms. To combat microbial infections,…”
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Synthesis and Molecular Docking of Curcumin-Derived Pyrazole-Thiazole Hybrids as Potent α-Glucosidase Inhibitors by Al-Humaidi, Jehan, Albedair, Lamia A, Maliwal, Deepika, E A Zaki, Magdi E A, Al-Hussain, Sami A, Pissurlenkar, Raghuvir, Mukhrish, Yousef E, Abolibda, Tariq Z M, Gomha, Sobhi

“…α Glucosidase inhibitors are critical for diabetes management, with pyrazoles and thiazoles emerging as effective options. This research highlights…”
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2‐Chloroquinolinyl‐thiazolidine‐2,4‐dione Hybrids as Potential α‐Amylase Inhibitors: Synthesis, Biological Evaluations, and In Silico Studies by Karmur, Sheetal B., Dholariya, Monil P., Patel, Anilkumar S., Karmur, Manisha B., Maliwal, Deepika, Pissurlenkar, Raghuvir R. S., Bhalodia, Jasmin J., Kaneria, Mital J., Ambasana, Mrunal, Bapodra, Atul H., Kapuriya, Naval P.

“…Recently, molecular hybridization strategy has paved a way to develop novel lead compounds for the α‐amylase targeted antidiabetic therapy. In this study, we…”
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Design, Synthesis and Antidiabetic Activity of Biphenylcarbonitrile‐Thiazolidinedione Conjugates as Potential α‐Amylase Inhibitors by Rathod, Chirag H., Nariya, Pankajkumar B., Maliwal, Deepika, Pissurlenkar, Raghuvir RS, Kapuriya, Naval P., Patel, Anilkumar S.

“…The α‐amylase inhibition has been considered as an effective therapeutic approach against chronic Type 2 Diabetes mellitus (DM). In the present study, a series…”
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QSAR modeling of some substituted alkylidenepyridazin-3-one as a non-cAMP-based antiplatelet agent by Vays, Vivek K., Jain, Anurekha, Ghate, Manjunath, Maliwal, Deepika

“…This study deals with the quantitative structure-activity relationship (QSAR) study of a series of 5-alkylidenepyridazine-3 ( 2H )-one as a novel non…”
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