Search Results - "Malisauskas, M"

In‐depth comparison of N‐glycosylation of human plasma‐derived factor VIII and different recombinant products: from structure to clinical implications by Canis, K., Anzengruber, J., Garenaux, E., Feichtinger, M., Benamara, K., Scheiflinger, F., Savoy, L.‐A., Reipert, B. M., Malisauskas, M.

“…Essentials Glycosylation heterogeneity of recombinant proteins affects pharmacokinetics and immunogenicity. N‐glycomics/glycoproteomics of plasma‐derived…”
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Comparative analysis of marketed factor VIII products: recombinant products are not alike vis‐a‐vis soluble protein aggregates and subvisible particles by Anzengruber, J., Lubich, C., Prenninger, T., Gringeri, A., Scheiflinger, F., Reipert, B. M., Malisauskas, M.

“…Essentials Aggregation is a critical quality attribute of protein therapeutics influencing immunogenicity. Aggregates and subvisible particles in 9 recombinant…”
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Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson's disease patients by Wilhelm, K. R., Yanamandra, K., Gruden, M. A., Zamotin, V., Malisauskas, M., Casaite, V., Darinskas, A., Forsgren, L., Morozova-Roche, L. A.

“…Peripheral immune responses can be sensitive indicators of disease pathology. We evaluated the autoimmune reactions to endocrine (insulin) and astrocytical…”
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Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid? by Malisauskas, M, Darinskas, A, Zamotin, V V, Gharibyan, A, Kostanyan, I A, Morozova-Roche, L A

“…In the current study we investigated the molecular mechanisms of cytotoxicity of amyloid oligomers of horse milk lysozyme. We have shown that lysozyme forms…”
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Amyloidogenic properties of the artificial protein albebetin and its biologically active derivatives. The role of electrostatic interactions in fibril formation by Lavrikova, M A, Zamotin, V V, Malisauskas, M, Chertkova, R V, Kostanyan, I A, Dolgikh, D A, Kirpichnikov, M P, Morozova-Roche, L A

“…The artificial protein albebetin (ABB) and its derivatives containing biologically active fragments of natural proteins form fibrils at physiological pH. The…”
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Amyloid Protofilaments from the Calcium-binding Protein Equine Lysozyme: Formation of Ring and Linear Structures Depends on pH and Metal Ion Concentration by Mališauskas, Mantas, Zamotin, Vladimir, Jass, Jana, Noppe, Wim, Dobson, Christopher M., Morozova-Roche, Ludmilla A.

“…The calcium-binding equine lysozyme has been found to undergo conversion into amyloid fibrils during incubation in solution at acidic pH. At pH 4.5 and 57 °C,…”
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Does the Cytotoxic Effect of Transient Amyloid Oligomers from Common Equine Lysozyme in Vitro Imply Innate Amyloid Toxicity? by Malisauskas, Mantas, Ostman, Johan, Darinskas, Adas, Zamotin, Vladimir, Liutkevicius, Evaldas, Lundgren, Erik, Morozova-Roche, Ludmilla A.

“…In amyloid diseases, it is not evident which protein aggregates induce cell death via specific molecular mechanisms and which cause damage because of their…”
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Fibrillation of Carrier Protein Albebetin and Its Biologically Active Constructs. Multiple Oligomeric Intermediates and Pathways by Morozova-Roche, Ludmilla A, Zamotin, Vladimir, Malisauskas, Mantas, Öhman, Anders, Chertkova, Rita, Lavrikova, Marika A, Kostanyan, Irina A, Dolgikh, Dmiltry A, Kirpichnikov, Michail P

“…We showed that the genetically engineered carrier-protein albebetin and its biologically active constructs with interferon-α2 octapeptide LKEKKYSP or…”
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Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: Autoantibodies to A beta sub(() sub(2) sub(5) sub(-) sub(3) sub(5) sub()) oligomers, S100b and neurotransmitters by Gruden, MA, Davidova, T B, Malisauskas, M, Sewell, RDE, Voskresenskaya, NI, Wilhelm, K, Elistratova, E I, Sherstnev, V V, Morozova-Roche, LA

“…Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as…”
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Autoimmune responses to amyloid structures of Abeta(25-35) peptide and human lysozyme in the serum of patients with progressive Alzheimer's disease by Gruden, M A, Davudova, T B, Malisauskas, M, Zamotin, V V, Sewell, R D E, Voskresenskaya, N I, Kostanyan, I A, Sherstnev, V V, Morozova-Roche, L A

“…We have found an increased level of serum antibodies to the prefibrillar structures of both Abeta(25-35) peptide and human lysozyme in Alzheimer's disease (AD)…”
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