Search Results - "Malipiero, U."

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet by Ehses, J. A, Meier, D. T, Wueest, S, Rytka, J, Boller, S, Wielinga, P. Y, Schraenen, A, Lemaire, K, Debray, S, Van Lommel, L, Pospisilik, J. A, Tschopp, O, Schultze, S. M, Malipiero, U, Esterbauer, H, Ellingsgaard, H, Rütti, S, Schuit, F. C, Lutz, T. A, Böni-Schnetzler, M, Konrad, D, Donath, Marc Y

“…Aims/hypothesis Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are…”
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Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation by Weller, M, Malipiero, U, Aguzzi, A, Reed, J C, Fontana, A

“…The majority of human malignant glioma cells express Fas/APO-1 and are susceptible to Fas/APO-1 antibody-mediated apoptosis in vitro. The sensitivity of…”
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On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases by Frei, K, Malipiero, U V, Leist, T P, Zinkernagel, R M, Schwab, M E, Fontana, A

“…Interleukin 6 (IL6) was found to be produced in the central nervous system (CNS) of ICR+/+ mice infected with lymphocytic choriomeningitis virus (LCMV) or with…”
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Production of hemopoietic colony-stimulating factors by astrocytes by Malipiero, UV, Frei, K, Fontana, A

“…Astrocytes may play a central role in regulation of immune mediated processes in the central nervous system. By their inducible expression of MHC class II Ag…”
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Cloning of the Human Puromycin‐Sensitive Aminopeptidase and Evidence for Expression in Neurons by Tobler, A. R., Constam, D. B., Schmitt‐Gräff, A., Malipiero, U., Schlapbach, R., Fontana, A.

“…: The puromycin‐sensitive aminopeptidase (PSA) is thought to contribute to the degradation of enkephalins. Besides being the most abundant aminopeptidase in…”
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Modulation of the immune response by transforming growth factor beta by Fontana, A, Constam, D B, Frei, K, Malipiero, U, Pfister, H W

“…For the past several years immunologists have been fascinated by a series of experiments showing that transforming growth factor beta (TGF beta) suppresses T-…”
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Astrocytes and microglia produce interleukin-12 p40 by Constantinescu, C S, Frei, K, Wysocka, M, Trinchieri, G, Malipiero, U, Rostami, A, Fontana, A

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Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response by LEVY, N. S, MALIPIERO, U. V, LEBECQUE, S. G, GEARHART, P. J

“…The dynamics of somatic mutation in Ig variable genes was investigated in order to define a population of B cells undergoing mutation. BALB/cJ mice were…”
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A new look at the role of p53 in leukemia cell sensitivity to chemotherapy by TREPEL, M, SCHEDING, S, GROSCURTH, P, HORNY, H.-P, MALIPIERO, U, BRUGGER, W, DICHGANS, J, WELLER, M

“…A gene encoding the p53 val135 mutant, which assumes mutant conformation at 38.5 degrees C and wild-type conformation at 32.5 degrees C, was introduced into…”
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TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells by Parsa, Roham, Lund, Harald, Tosevski, Ivana, Zhang, Xing-Mei, Malipiero, Ursula, Beckervordersandforth, Jan, Merkler, Doron, Prinz, Marco, Gyllenberg, Alexandra, James, Tojo, Warnecke, Andreas, Hillert, Jan, Alfredsson, Lars, Kockum, Ingrid, Olsson, Tomas, Fontana, Adriano, Suter, Tobias, Harris, Robert A.

“…Intracerebral levels of Transforming Growth Factor beta (TGFβ) rise rapidly during the onset of experimental autoimmune encephalomyelitis (EAE), a mouse model…”
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Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16 by Atanasoski, S., Toldo, S.Solinas, Malipiero, U., Schreiber, E., Fries, R., Fontana, A.

“…N-Oct 3 is a human POU domain transcription factor that binds to the octamer sequence ATGCAAAT. The protein is expressed in the central nervous system during…”
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Microglia and tumor rejection by Frei, K, Malipiero, U, Piani, D, Fontana, A

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Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection by Schmid, R A, Stammberger, U, Hillinger, S, Gaspert, A, Boasquevisque, C H, Malipiero, U, Fontana, A, Weder, W

“…The interaction between Fas and its ligand (FasL) induces apoptosis in the Fas-expressing cell. We hypothesized that liposome-mediated FasL gene transduction…”
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Transforming growth factor-beta (TGF-beta)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF- beta receptors by Siepl, C, Malipiero, UV, Fontana, A

“…Three ovalbumin-specific T helper cell lines (OVA-7T cells) that differ in their susceptibility to the immunosuppressive effects of transforming growth…”
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Production of macrophage colony-stimulating factor by astrocytes and brain macrophages by Frei, K, Nohava, K, Malipiero, U V, Schwerdel, C, Fontana, A

“…Morphological hallmarks of inflammatory and degenerative diseases of the brain are hypertrophy of astrocytes and accumulation of macrophages recruited from…”
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TGFβ directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes by Paglinawan, Rey, Malipiero, Ursula, Schlapbach, Ralph, Frei, Karl, Reith, Walter, Fontana, Adriano

“…In experimental autoimmune encephalomyelitis, the acute phase of the disease is produced by T‐helper lymphocyte type 1 (TH1), which produces mainly TNFα and…”
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells. Despite the presence of inducing signals GM-CSF is not expressed in vivo by Frei, K, Piani, D, Malipiero, UV, Van Meir, E, de Tribolet, N, Fontana, A

“…One of the morphologic hallmarks of human gliomas are inflammatory infiltrates with accumulation of macrophages in the tumor site. The signals leading to the…”
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TGF‐β‐treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF‐c‐Met pathway by Lalive, Patrice H., Paglinawan, Rey, Biollaz, Gregoire, Kappos, Elisabeth A., Leone, Dino P., Malipiero, Ursula, Relvas, Joao B., Moransard, Martijn, Suter, Tobias, Fontana, Adriano

“…In acute experimental autoimmune encephalomyelitis (EAE), demyelination is induced by myelin‐specific CD4+ T lymphocytes and myelin‐specific antibodies…”
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Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia by Constam, DB, Philipp, J, Malipiero, UV, ten Dijke, P, Schachner, M, Fontana, A

“…The type beta transforming growth factors (TGF) are potent regulators of the growth and functions of lymphocytes and macrophages. Recently the human…”
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Generation of antibody diversity before and after immunization by Gearhart, P J, Lawler, A M, Levy, N S, Lebecque, S G, Malipiero, U V

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