Search Results - "Malinauskas, Tomas"

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses by Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, Townsend, Alain R.

“…There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle…”
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Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchański, Tomasz, Masiulis, Simonas, Stec, Wojciech J., Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu

“…Type A γ-aminobutyric acid (GABA A ) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in the…”
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient by Zhou, Daming, Duyvesteyn, Helen M. E., Chen, Cheng-Pin, Huang, Chung-Guei, Chen, Ting-Hua, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Ma, Che, Huo, Jiandong, Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N. M., Tan, Tiong Kit, Rijal, Pramila, Donat, Robert F., Godwin, Kerry, Buttigieg, Karen R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles W., Gilbert-Jaramillo, Javier, Knight, Michael L., James, William, Owens, Raymond J., Naismith, James H., Townsend, Alain R., Fry, Elizabeth E., Zhao, Yuguang, Ren, Jingshan, Stuart, David I., Huang, Kuan-Ying A.

“…The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A,…”
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Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins by Emmenegger, Marc, Kumar, Sreedhar Saseendran, Emmenegger, Vishalini, Malinauskas, Tomas, Buettner, Thomas, Rose, Laura, Schierack, Peter, Sprinzl, Martin F, Sommer, Clemens J, Lackner, Karl J, Aguzzi, Adriano, Roggenbuck, Dirk, Frauenknecht, Katrin B M

“…Antiphospholipid antibodies (aPL), assumed to cause antiphospholipid syndrome (APS), are notorious for their heterogeneity in targeting phospholipids and…”
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling by Griffiths, Samuel C., Schwab, Rebekka A., El Omari, Kamel, Bishop, Benjamin, Iverson, Ellen J., Malinauskas, Tomas, Dubey, Ramin, Qian, Mingxing, Covey, Douglas F., Gilbert, Robert J. C., Rohatgi, Rajat, Siebold, Christian

“…Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to…”
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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling by Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Ingham, Philip W, Covey, Douglas F, Siebold, Christian, Rohatgi, Rajat

“…The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target…”
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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling by Dubey, Ramin, van Kerkhof, Peter, Jordens, Ingrid, Malinauskas, Tomas, Pusapati, Ganesh V, McKenna, Joseph K, Li, Dan, Carette, Jan E, Ho, Mitchell, Siebold, Christian, Maurice, Madelon, Lebensohn, Andres M, Rohatgi, Rajat

“…R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin…”
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Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex by Janssen, Bert J C, Malinauskas, Tomas, Weir, Greg A, Cader, M Zameel, Siebold, Christian, Jones, E Yvonne

“…Semaphorin-plexin cell-cell signaling is important in tissue development, with roles in axon guidance, immunity and cancer. The structure of the complex formed…”
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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 by Siebold, Christian, Jones, E Yvonne, Malinauskas, Tomas, Aricescu, A Radu, Lu, Weixian

“…WIF-1 inhibits Wnt signaling by binding Wnt ligands. Structural and biochemical analysis of WIF-1 shows the EGF-like domains wrapping back to contact the…”
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Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells by Carlon-Andres, Irene, Malinauskas, Tomas, Padilla-Parra, Sergi

“…The HIV-1 envelope glycoprotein (Env) mediates viral entry into the host cell. Although the highly dynamic nature of Env intramolecular conformations has been…”
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Structural insights into proteoglycan-shaped Hedgehog signaling by Whalen, Daniel M., Malinauskas, Tomas, Gilbert, Robert J. C., Siebold, Christian

“…Hedgehog (Hh) morphogens play fundamental roles during embryogenesis and adulthood, in health and disease. Multiple cell surface receptors regulate the Hh…”
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Structural Basis for Plexin Activation and Regulation by Kong, Youxin, Janssen, Bert J.C., Malinauskas, Tomas, Vangoor, Vamshidhar R., Coles, Charlotte H., Kaufmann, Rainer, Ni, Tao, Gilbert, Robert J.C., Padilla-Parra, Sergi, Pasterkamp, R. Jeroen, Jones, E. Yvonne

“…Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and…”
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Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder by Cai, Na, Li, Yihan, Chang, Simon, Liang, Jieqin, Lin, Chongyun, Zhang, Xiufei, Liang, Lu, Hu, Jingchu, Chan, Wharton, Kendler, Kenneth S., Malinauskas, Tomas, Huang, Guo-Jen, Li, Qibin, Mott, Richard, Flint, Jonathan

“…Control over the number of mtDNA molecules per cell appears to be tightly regulated, but the mechanisms involved are largely unknown. Reversible alterations in…”
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A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling by Gorvin, Caroline M, Babinsky, Valerie N, Malinauskas, Tomas, Nissen, Peter H, Schou, Anders J, Hanyaloglu, Aylin C, Siebold, Christian, Jones, E Yvonne, Hannan, Fadil M, Thakker, Rajesh V

“…The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through G and G to stimulate cytosolic calcium (Ca ) and…”
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Structural insights into Frizzled3 through nanobody modulators by Hillier, James, Zhao, Yuguang, Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Chang, Tao-Hsin, Yi, Gangshun, Duyvesteyn, Helen M. E., Yu, Jing, Lu, Weixian, Pardon, Els, Steyaert, Jan, Zhu, Yanan, Ni, Tao, Jones, E. Yvonne

“…The Wnt receptor Frizzled3 (FZD3) is important for brain axonal development and cancer progression. We report structures of FZD3 in complex with extracellular…”
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Molecular mechanism of BMP signal control by Twisted gastrulation by Malinauskas, Tomas, Moore, Gareth, Rudolf, Amalie F., Eggington, Holly, Belnoue-Davis, Hayley L., El Omari, Kamel, Griffiths, Samuel C., Woolley, Rachel E., Duman, Ramona, Wagner, Armin, Leedham, Simon J., Baldock, Clair, Ashe, Hilary L., Siebold, Christian

“…Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds…”
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Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1 by Malinauskas, Tomas

“…Palmitoylated Wnt proteins comprise a conserved family of secreted signaling molecules associated with variety of human cancers. WIF domain of the human WIF…”
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Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning by Rozbesky, Daniel, Robinson, Ross A., Jain, Vitul, Renner, Max, Malinauskas, Tomas, Harlos, Karl, Siebold, Christian, Jones, E. Yvonne

“…Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of…”
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