Search Results - "Malim, Michael H."

APOBEC proteins and intrinsic resistance to HIV-1 infection by Malim, Michael H

“…have clear therapeutic merit, and therefore deserve aggressive pursuit…”
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HIV-1 accessory proteins--ensuring viral survival in a hostile environment by Malim, Michael H, Emerman, Michael

“…One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes them from other retroviruses is the array of "accessory" proteins…”
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Increasing best practice data sharing at PLOS Pathogens by Cadwallader, Lauren, Haldar, Kasturi, Malim, Michael H

“…PLOS Pathogens authors share their data in a number of different places—discipline-specific repositories (e.g., Sequence Read Archive and Gene Expression…”
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Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection by Goujon, Caroline, Moncorgé, Olivier, Bauby, Hélène, Doyle, Tomas, Ward, Christopher C., Schaller, Torsten, Hué, Stéphane, Barclay, Wendy S., Schulz, Reiner, Malim, Michael H.

“…Here, a protein known as MX2 is shown to be a major effector of interferon-α-mediated resistance to HIV-1 infection: susceptibility of the HIV-1 virus to…”
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Persistent HIV-1 replication maintains the tissue reservoir during therapy by Lorenzo-Redondo, Ramon, Fryer, Helen R., Bedford, Trevor, Kim, Eun-Young, Archer, John, Kosakovsky Pond, Sergei L., Chung, Yoon-Seok, Penugonda, Sudhir, Chipman, Jeffrey G., Fletcher, Courtney V., Schacker, Timothy W., Malim, Michael H., Rambaut, Andrew, Haase, Ashley T., McLean, Angela R., Wolinsky, Steven M.

“…Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in…”
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Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells by Goujon, Caroline, Malim, Michael H

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Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases by Ng, Joseph C F, Quist, Jelmar, Grigoriadis, Anita, Malim, Michael H, Fraternali, Franca

“…Abstract APOBEC3 cytidine deaminases are largely known for their innate immune protection from viral infections. Recently, members of the family have been…”
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Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion Encapsidation by HUTHOFF, Hendrik, MALIM, Michael H

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Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1 by Apolonia, Luis, Schulz, Reiner, Curk, Tomaž, Rocha, Paula, Swanson, Chad M, Schaller, Torsten, Ule, Jernej, Malim, Michael H

“…The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are cell-encoded cytidine deaminases, some of which, such as APOBEC3G…”
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Open Science at PLOS Pathogens by Cadwallader, Lauren, Haldar, Kasturi, Kirk, Rebecca, Mabbott, Neil A, Malim, Michael H

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Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction by Dicks, Matthew D J, Betancor, Gilberto, Jimenez-Guardeño, Jose M, Pessel-Vivares, Lucie, Apolonia, Luis, Goujon, Caroline, Malim, Michael H

“…Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the…”
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Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein by Calvaresi, Valeria, Wrobel, Antoni G., Toporowska, Joanna, Hammerschmid, Dietmar, Doores, Katie J., Bradshaw, Richard T., Parsons, Ricardo B., Benton, Donald J., Roustan, Chloë, Reading, Eamonn, Malim, Michael H., Gamblin, Steve J., Politis, Argyris

“…SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable…”
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Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4+ T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination by Gillick, Kieran, Pollpeter, Darja, Phalora, Prabhjeet, Kim, Eun-Young, Wolinsky, Steven M, Malim, Michael H

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Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine Deamination by BISHOP, Kate N, HOLMES, Rebecca K, MALIM, Michael H

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TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction by Khan, Hataf, Winstone, Helena, Jimenez-Guardeño, Jose M, Graham, Carl, Doores, Katie J, Goujon, Caroline, Matthews, David A, Davidson, Andrew D, Rihn, Suzannah J, Palmarini, Massimo, Neil, Stuart J D, Malim, Michael H

“…Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit…”
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Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets by KONING, Fransje A, NEWMAN, Edmund N. C, KIM, Eun-Young, KUNSTMAN, Kevin J, WOLINSKY, Steven M, MALIM, Michael H

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A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2 by Goujon, Caroline, Greenbury, Rebecca A, Papaioannou, Stelios, Doyle, Tomas, Malim, Michael H

“…We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus resistance 2 (MX2). First, we…”
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Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study by Pickering, Suzanne, Batra, Rahul, Merrick, Blair, Snell, Luke B, Nebbia, Gaia, Douthwaite, Sam, Reid, Fiona, Patel, Amita, Kia Ik, Mark Tan, Patel, Bindi, Charalampous, Themoula, Alcolea-Medina, Adela, Lista, Maria Jose, Cliff, Penelope R, Cunningham, Emma, Mullen, Jane, Doores, Katie J, Edgeworth, Jonathan D, Malim, Michael H, Neil, Stuart J D, Galão, Rui Pedro

“…Lateral flow devices (LFDs) for rapid antigen testing are set to become a cornerstone of SARS-CoV-2 mass community testing, although their reduced sensitivity…”
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Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection by Kim, Eun-Young, Lorenzo-Redondo, Ramon, Little, Susan J, Chung, Yoon-Seok, Phalora, Prabhjeet K, Maljkovic Berry, Irina, Archer, John, Penugonda, Sudhir, Fischer, Will, Richman, Douglas D, Bhattacharya, Tanmoy, Malim, Michael H, Wolinsky, Steven M

“…Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and…”
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Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules by GALLOIS-MONTBRUN, Sarah, KRAMER, Beatrice, SWANSON, Chad M, BYERS, Helen, LYNHAM, Steven, WARD, Malcolm, MALIM, Michael H

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