Search Results - "Maliken, Bryan D"

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    Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart by Fu, Xing, Khalil, Hadi, Kanisicak, Onur, Boyer, Justin G, Vagnozzi, Ronald J, Maliken, Bryan D, Sargent, Michelle A, Prasad, Vikram, Valiente-Alandi, Iñigo, Blaxall, Burns C, Molkentin, Jeffery D

    Published in The Journal of clinical investigation (01-05-2018)
    “…Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring…”
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    Genetic lineage tracing defines myofibroblast origin and function in the injured heart by Kanisicak, Onur, Khalil, Hadi, Ivey, Malina J., Karch, Jason, Maliken, Bryan D., Correll, Robert N., Brody, Matthew J., J. Lin, Suh-Chin, Aronow, Bruce J., Tallquist, Michelle D., Molkentin, Jeffery D.

    Published in Nature communications (22-07-2016)
    “…Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with…”
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    Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak by Karch, Jason, Schips, Tobias G, Maliken, Bryan D, Brody, Matthew J, Sargent, Michelle A, Kanisicak, Onur, Molkentin, Jeffery D

    Published in eLife (17-11-2017)
    “…Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two…”
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    Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective by Alam, Perwez, Maliken, Bryan D, Jones, Shannon M, Ivey, Malina J, Wu, Zhichao, Wang, Yigang, Kanisicak, Onur

    “…The limited ability of mammalian adult cardiomyocytes to proliferate following an injury to the heart, such as myocardial infarction, is a major factor that…”
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    Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart by Khalil, Hadi, Kanisicak, Onur, Vagnozzi, Ronald J., Johansen, Anne Katrine, Maliken, Bryan D., Prasad, Vikram, Boyer, Justin G., Brody, Matthew J., Schips, Tobias, Kilian, Katja K., Correll, Robert N., Kawasaki, Kunito, Nagata, Kazuhiro, Molkentin, Jeffery D.

    Published in JCI insight (08-08-2019)
    “…Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple…”
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    Differences In Hepatic Expression of Iron, Inflammation and Stress-Related Genes in Patients with Nonalcoholic Steatohepatitis by Handa, Priya, Maliken, Bryan D, Nelson, James E, Hennessey, Kelly A, Akhila Vemulakonda, L, Morgan-Stevenson, Vicki, Dhillon, Barjinder K, Gupta, Rohit, Yeh, Matthew M, Kowdley, Kris V

    Published in Annals of hepatology (01-01-2017)
    “…AbstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic…”
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    Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid by Hochberg, Jessica T., Sohal, Aalam, Handa, Priya, Maliken, Bryan D., Kim, Take-Kyun, Wang, Kai, Gochanour, Eric, Li, Yu, Rose, J. Bart, Nelson, James E., Lindor, Keith D., LaRusso, Nicholas F., Kowdley, Kris V.

    Published in JHEP reports (01-06-2023)
    “…Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease that can lead to end-stage liver disease and cholangiocarcinoma…”
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    Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis by Handa, Priya, Thomas, Sunil, Morgan‐Stevenson, Vicki, Maliken, Bryan D., Gochanour, Eric, Boukhar, Sarag, Yeh, Matthew M., Kowdley, Kris V.

    Published in Journal of leukocyte biology (01-05-2019)
    “…We have previously demonstrated that iron overload in hepatic reticuloendothelial system cells (RES) is associated with severe nonalcoholic steatohepatitis…”
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    Gata4-Dependent Differentiation of c-Kit+–Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart by Maliken, Bryan D, Kanisicak, Onur, Karch, Jason, Khalil, Hadi, Fu, Xing, Boyer, Justin G, Prasad, Vikram, Zheng, Yi, Molkentin, Jeffery D

    Published in Circulation (New York, N.Y.) (04-09-2018)
    “…BACKGROUND:Although c-Kit adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such…”
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    Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease by Maliken, Bryan D., Nelson, James E., Klintworth, Heather M., Beauchamp, Mary, Yeh, Matthew M., Kowdley, Kris V.

    Published in Hepatology (Baltimore, Md.) (01-05-2013)
    “…The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of…”
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    Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin by Maliken, Bryan D, Avrin, William F, Nelson, James E, Mooney, Jody, Kumar, Sankaran, Kowdley, Kris V

    Published in Annals of hepatology (01-01-2012)
    “…There is an ongoing clinical need for novel methods to measure hepatic iron content (HIC) noninvasively. Both magnetic resonance imaging (MRI) and…”
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    Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes by Alam, Perwez, Maliken, Bryan D, Ivey, Malina J, Jones, Shannon M, Kanisicak, Onur

    Published in Journal of visualized experiments (10-10-2020)
    “…Ex vivo culture of the adult mammalian cardiomyocytes (CMs) presents the most relevant experimental system for the in vitro study of cardiac biology. Adult…”
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    Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling by Brody, Matthew J., Schips, Tobias G., Vanhoutte, Davy, Kanisicak, Onur, Karch, Jason, Maliken, Bryan D., Blair, N. Scott, Sargent, Michelle A., Prasad, Vikram, Molkentin, Jeffery D.

    Published in Molecular and cellular biology (01-01-2016)
    “…Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has…”
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    H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics by Shawki, Ali, Knight, Patrick B, Maliken, Bryan D, Niespodzany, Eric J, Mackenzie, Bryan

    Published in Current topics in membranes (2012)
    “…Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring membrane transport protein. Animal models establish that DMT1 plays…”
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    The hepcidin circuits act: Balancing iron and inflammation by Maliken, Bryan D., Nelson, James E., Kowdley, Kris V., Kowdley, Kris, McCaughan, Geoffrey, Trautwein, Christian

    Published in Hepatology (Baltimore, Md.) (01-05-2011)
    “…Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide. It is expressed and secreted by a variety of cell types in…”
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