Search Results - "Maliken, Bryan D"
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Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Published in The Journal of clinical investigation (01-05-2018)“…Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring…”
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Genetic lineage tracing defines myofibroblast origin and function in the injured heart
Published in Nature communications (22-07-2016)“…Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with…”
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Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice
Published in American journal of physiology: Gastrointestinal and liver physiology (15-01-2016)“…The aim of this study was to determine the effect of iron overload in the development of nonalcoholic steatohepatitis (NASH) in a genetically obese mouse model…”
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Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Published in eLife (17-11-2017)“…Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two…”
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Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective
Published in International journal of molecular sciences (03-12-2021)“…The limited ability of mammalian adult cardiomyocytes to proliferate following an injury to the heart, such as myocardial infarction, is a major factor that…”
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Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis
Published in Hepatology (Baltimore, Md.) (01-07-2014)“…Obesity and adiponectin depletion have been associated with the occurrence of nonalcoholic fatty liver disease (NAFLD). The goal of this study was to identify…”
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Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction
Published in Journal of the American Heart Association (06-08-2019)“…Background Myocardial infarction results in a large-scale cardiomyocyte loss and heart failure due to subsequent pathological remodeling. Whereas zebrafish and…”
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Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart
Published in JCI insight (08-08-2019)“…Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple…”
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Differences In Hepatic Expression of Iron, Inflammation and Stress-Related Genes in Patients with Nonalcoholic Steatohepatitis
Published in Annals of hepatology (01-01-2017)“…AbstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic…”
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Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid
Published in JHEP reports (01-06-2023)“…Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease that can lead to end-stage liver disease and cholangiocarcinoma…”
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Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
Published in Journal of leukocyte biology (01-05-2019)“…We have previously demonstrated that iron overload in hepatic reticuloendothelial system cells (RES) is associated with severe nonalcoholic steatohepatitis…”
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Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell
Published in Circulation (New York, N.Y.) (21-08-2018)Get full text
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Gata4-Dependent Differentiation of c-Kit+–Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart
Published in Circulation (New York, N.Y.) (04-09-2018)“…BACKGROUND:Although c-Kit adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such…”
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Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease
Published in Hepatology (Baltimore, Md.) (01-05-2013)“…The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of…”
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Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin
Published in Annals of hepatology (01-01-2012)“…There is an ongoing clinical need for novel methods to measure hepatic iron content (HIC) noninvasively. Both magnetic resonance imaging (MRI) and…”
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Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes
Published in Journal of visualized experiments (10-10-2020)“…Ex vivo culture of the adult mammalian cardiomyocytes (CMs) presents the most relevant experimental system for the in vitro study of cardiac biology. Adult…”
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Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling
Published in Molecular and cellular biology (01-01-2016)“…Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has…”
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H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics
Published in Current topics in membranes (2012)“…Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring membrane transport protein. Animal models establish that DMT1 plays…”
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The hepcidin circuits act: Balancing iron and inflammation
Published in Hepatology (Baltimore, Md.) (01-05-2011)“…Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide. It is expressed and secreted by a variety of cell types in…”
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